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Liu Hu, Xing Cai, Suzhen Dong, Yongjia Zhen, Jidi Hu, Shenjun Wang, Jingwen Jiang, Jiawu Huang, Yuqiao Han, Yu Qian, Yanqiu Yuan, Wenhao Hu, Synthesis and Anticancer Activity of Novel Actinonin Derivatives as HsPDF Inhibitors. Journal of Medicinal Chemistry, 2020, 63, 6959-6978. (IF 6.205)
Jiuling Li; Dan Zhang; Jianghui Chen; Chaoqun Ma; Wenhao Hu, Enantioselective Synthesis of Fluoroalkyl-Substituted syn-Diamines by the Asymmetric gem-Difunctionalization of 2,2,2-Trifluorodiazoethane. ACS Catalysis, 2020, 10, 4559-4565. (IF 135)
Jiuwei Che,Li Niu,Shikun Jia,Dong Xing,Wenhao Hu, Enantioselective three-component aminomethylation of α-diazo ketones with alcohols and 1,3,5-triazines. Nature Communications. 2020, 11, 1511. (IF 12.121)
Guizhi Dong; Ming Bao; Xiongda Xie; Shikun Jia; Wenhao Hu; Xinfang Xu; Asymmetric Allylation by Chiral Organocatalyst Promoted Formal Hetero-Ene Reactions of Alkylgold Intermediates. Angew Chem Int Edit, 2020, doi.org/10.1002/anie.202012678 (IF 12.959)
Dan Zhang, Xin Wang, Mengchu Zhang, Zhenghui Kang, Guolan Xiao, Xinfang Xu, and Wenhao Hu， Highly Enantioselective Trapping of Carboxylic Oxonium Ylides with Imines for Direct Assembly of Enantioenriched γ-Butenolides, CCS Chem. 2020, 2, 432–439.
Xinxin Lv, Shuhao Liu, Su Zhou, Guizhi Dong, Dong Xing, Xinfang Xu, and Wenhao Hu, Asymmetric Three-Component Propargyloxylation for Direct Assembly of Polyfunctionalized Chiral Succinate Derivatives, CCS Chem. 2020, 2, 1903–1912.
Zhenghui Kang, Yongheng Wang, Dan Zhang, Ruibo Wu, Xinfang Xu, Wenhao Hu, Asymmetric Counter-Anion-Directed Aminomethylation: Synthesis of Chiral β-Amino Acids via Trapping of an Enol Intermediate. Journal of the American Chemical Society 2019, 141, 1473-1478. (IF 14.612)
Deyu Kong,Tao Xue,Bin Guo,Jianjun Cheng,Shunyin Liu,Jianhai Wei,Zhengyu Lu,Haoran Liu,Guoqing Gong,Tian Lan,Wenhao Hu, Yushe Yang, Optimization of P2Y12 Antagonist Ethyl 6-(4-((Benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZD1283) Led to the Discovery of an Oral Antiplatelet Agent with Improved Druglike Properties. Journal of Medicinal Chemistry, 2019, 62, 3088-3106. (IF 6.205)
Dan Zhang, Zhenghui Kang, Junwen Liu, Wenhao Hu, Metal-Dependent Umpolung Reactivity of Carbenes Derived from Cyclopropenes. iScience 2019, 14, 292-300. (IF 4.447)
Yuanxiang Wang,* Wenhao Hu, and Yanqiu Yuan.* Protein Arginine Methyltransferase 5 (PRMT5) as an Anticancer Target and Its Inhibitor Discovery. J. Med. Chem. 2018, DOI: 1021/acs.jmedchem.8b00598.
Shunying Liu, Wenfeng Yao, Yuan Liu, Qinghua Wei, Jianghui Chen, Xiang Wu, Fei Xia,* Wenhao Hu*. A Rh(II)-catalyzed multicomponent reaction by trapping an a-amino enol intermediate in a traditional two-component reaction pathway. Sci. Adv. 2017, 3: e1602467. DOI: 10.1126/sciadv.1602467.
Shunying Liu, Jun Jiang, Jianghui Chen, Qinghua Wei, Wenfeng Yao, Fei Xia* and Wenhao Hu*, A DFT calculation-inspired Rh(I)-catalyzed reaction via suppression of a-H shift in a alkyldiazoacetates. Chem. Sci. 2017, 8, 4312–4317.
Liqin Jiang, Weifeng Jin, and Wenhao Hu*, Double C−H Functionalization of Indoles via Three-Component Reactions/CuCl2-Catalyzed Aerobic Dehydrogenative Coupling for the Synthesis of Polyfunctional Cyclopenta[b]indoles, ACS Catal. 2016, 6, 6146-6150.
Dan Zhang, Jun Zhou, Fei Xia, Zhenghui Kang, and Wenhao Hu*, Bond cleavage, fragment modification and reassembly in enantioselective three-component reactions, Nat Commun. 2015, 6, 5801.
Xiaochu Ma, Jun Jiang, Siying Lv, Wenfeng Yao, Yang Yang, Shunying Liu,* Fei Xia, and Wenhao Hu*, An Ylide Transformation of Rhodium(I) Carbene: Enantioselective Three-Component Reaction through Trapping of Rhodium(I)-Associated Ammonium Ylides by β-Nitroacrylates, Angew. Chem. Int. Ed. 2014, 53, 13136-13139.
Shikun Jia, Dong Xing, Dan Zhang, and Wenhao Hu*, Catalytic Asymmetric Functionalization of Aromatic C-H Bonds by Electrophilic Trapping of Metal-Carbene-Induced Zwitterionic Intermediates, Angew. Chem. Int. Ed. 2014, 53, 13098-13101.
Xufeng Cao, Zhaoshuan Sun, Yongbing Cao, Ruilian Wang, Tongkai Cai, Wenjing Chu, Wenhao Hu,* and Yushe Yang*, Design, Synthesis, and Structure-Activity Relationship Studies of Novel Fused Heterocycles-Linked Triazoles with Good Activity and Water Solubility, J. Med. Chem. 2014, 57, 3687-3706.
Brendan Frett, Robert V. Brown, Mingliang Ma, Wenhao Hu, Haiyong Han, and Hong-yu Li*, Therapeutic Melting Pot of Never in Mitosis Gene A Related Kinase2 (Nek2): A Perspective on Nek2 as an Oncology Target and Recent Advancements in Nek2 Small Molecule Inhibition, J. Med. Chem. 2014, 57, 5835-5844.
Dan Zhang, Huang Qiu, Liqin Jiang,* Fengping Lv, Chaoqun Ma, and Wenhao Hu*,. Enantioselective Palladium(II) Phosphate Catalyzed Three-Component Reactions of Pyrrole, Diazoesters, and Imines. Angew. Chem. Int. Ed. 2013, 125, 13598-13602.
Changcheng Jing, Dong Xing, Yu Qian, Taoda Shi, Yun Zhao, and Wenhao Hu*, Diversity-Oriented Three-Component Reactions of Diazo Compounds with Anilines and 4-Oxo-Enoates. Angew. Chem. Int. Ed. 2013, 52, 9289-9292.
Xin Guo, and Wenhao Hu*, Novel Multicomponent Reactions via Trapping of Protic Onium Ylides with Electrophiles, Acc. Chem. Res. 2013, 46, 2427-2440.
Jun Jiang, Xiaoyu Guan, Shunying Liu, Baiyan Ren, Xiaochu Ma, Xin Guo, Fengping Lv, Xiang Wu, and Wenhao Hu*, Highly Diastereoselective Multicomponent Cascade Reactions: Efficient Synthesis of Functionalized 1-Indanols, Angew. Chem. Int. Ed. 2013, 52, 1539-1542.
Huang Qiu, Ming Li, Li-Qin Jiang, Feng-Ping Lv, Li Zan, Chang-Wei Zhai, Michael P. Doyle, and Wen-Hao Hu*, Highly enantioselective trapping of zwitterionic intermediates by imines, Nat. Chem. 2012, 4, 733-739.
Jun Jiang, Hua-Dong Xu, Jian-Bei Xi, Bai-Yan Ren, Feng-Ping Lv, Xin Guo, Li-Qin Jiang, Zhi-Yong Zhang, and Wenhao Hu*, Diastereoselectively Switchable Enantioselective Trapping of Carbamate Ammonium Ylides with Imines, J. Am. Chem. Soc. 2011, 133, 8428-8431.
Xiaoyu Guan, Liping Yang, and Wenhao Hu*, Cooperative Catalysis in Multicomponent Reactions: Highly Enantioselective Synthesis of γ-Hydroxyketones with a Quaternary Carbon Stereocenter, Angew. Chem. Int. Ed. 2010, 49, 2190-2192.
Xu Zhang, Haoxi Huang, Xin Guo, Xiaoyu Guan, Liping Yang, and Wenhao Hu*, Catalytic enantioselective trapping of an alcoholic oxonium ylide with aldehydes: Rh-II/Zr-IV-co-catalyzed three-component reactions of aryl diazoacetates, benzyl alcohol, and aldehydes, Angew. Chem. Int. Ed. 2008, 47, 6647–6649.
Wenhao Hu*, Xinfang Xu, Jing Zhou, Wei-Jun Liu, Haoxi Huang, Juan Hu, Liping Yang, and Liu-Zhu Gong*, Cooperative Catalysis with Chiral Brønsted Acid-Rh2(OAc)4: Highly Enantioselective Three-Component Reactions of Diazo Compounds with Alcohols and Imines, J. Am. Chem. Soc. 2008, 130, 7782-7783.
Haoxi Huang, Xin Guo, and Wenhao Hu*, Efficient Trapping of Oxonium Ylides with Imines: A Highly Diastereoselective Three-Component Reaction for the Synthesis of β-Amino-α-hydroxyesters with Quaternary Stereocenters, Angew. Chem. Int. Ed. 2007, 46, 1337-1339.
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