个人简介

1993年-1996年: 中山大学生命科学学院，生理学专业心血管药理学硕士研究生 1996年-1999年：中山大学生命科学学院，动物学专业天然产物药学博士研究生 1999年-2010年: 海王集团技术中心，资深研究员，高级经理 2010年至今: 中国科学院昆明植物研究所，研究员，博士生导师

研究领域

化学生物学、天然产物药学与药理学。 主要从事基于天然产物及其结构片段的创新药物评价和研发，其研究工作包括： (1) 靶点针对性的天然产物、天然产物衍生物、基于天然产物片段的新药创制和研发； (2) 天然产物心血管药理活性评价及成药性初步评价

药理学/药物化学 化学生物学、天然产物药学与药理学 主要从事基于天然产物及其结构片段的创新药物评价和研发

近期论文

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[1] Xiao C, Lian W, Zhou LT, Gao N, Xu L, Chen J, Wu MY*, Peng WL*, Zhao JH*. Interactions between depolymerized fucosylated glycosaminoglycan and coagulation proteases or inhibitors. Thromb Res. 2016;146: 59–68 [2] Lin LS, ·Wu MY,·Zhao JH*. The initiation and effects of plasma contact activation. Int J Hematol, 2016; 10.1007 [3] Zhao LY, Wu MY, Xiao C, Yang L, Zhou LT, Gao N, Li Z, Chen J, Chen JC, Liu JK*, Qian HB*, Zhao JH*. Discovery of an intrinsic tenase complex inhibitor: pure nonasaccharide from fucosylated glycosaminoglycan. Proc Natl Acad Sci USA, 2015, 112(27):8284–89 [4] Wu MY, Wen DD, Gao N, Xiao C, Xu L, Lian W, Peng WL, Jiang JM*, Zhao JH*. Anticoagulant and antithrombotic evaluation of native fucosylated chondroitin sulfates and their derivatives as selective inhibitors of intrinsic factor Xase. Eur J Med Chem, 2015, 92: 257–69. [5] Wu MY, Xu L, Zhao LY, Xiao C, Gao N, Luo L, Yang L, Li Z, Chen LY*, Zhao JH*. Structural analysis and antico-agulant acti-vities of the novel sulfated fucan possessing a regular well-defined repeating unit from sea cucumber. Mar Drugs, 2015, 13(4): 2063–84. [6] Gao N, Lu F, Xiao C, Yang L, Chen J, Zhou K, Wen DD, Li Z, Wu MY, Jiang JM, Liu GM*, Zhao JH*. β-Eliminative depolymeri-zation of the fucosylated chondroitin sulfate and anticoagulant activities of resulting fragments. Carbohydr Polym, 2015, 127: 427–37. [7] Lian W, Wu MY, Huang N, Gao N, Xiao C, Li Z, Zhang ZG, Zheng YT*, Peng WL*, Zhao JH*. Anti- HIV-1 activity and structure–activity-relationship study of a fucosylated glycosamino- glycan from an echinoderm by targeting the con-served CD4 induced epitope. Biochim Biophys Acta, 2013,1830: 4681– 4691 [8] Zhao LY, Lai SS, Huange R, Wu MY, Gao N, Xu L, Qin HB,* Peng WL, Zhao JH*. Structure and anticoagulant activity of fucosylated glycosaminoglycan degraded by deaminative cleavage. Carbohydr Polym. 2013 (98) 1514–1523 [9] Huang N, Wu MY, Zheng CB, Zhu L, Zhao JH*, Zheng YT*. The depolymerized fucosylated chondroitin sulfate from sea cucumber potently inhibits HIV replication via interfering with virus entry. Carbohyd Res. 2013 (380) 64–69 [10] Luo L, Wu MY, Xu L, Lian W, Xiang JY, Lu F, Gao N, Zhao JH*. Comparison of physico-chemical characterris-tics and anticoagulant activities of polysaccharides from three sea cucumbers. Mar Drugs, 2013; 11: 399–417. [11] Wu MY, Huang R, Wen DD, Gao N, He JB, Li Z, Zhao JH*. Structure and effect of sulfated fucose branches on anti-coagulant activity of the fucosylated chondroitin sulfate from sea cucumber Thelenata ananas. Carbohydr Polym, 2012; 87: 862-868 [12] Gao N, Wu MY, Liu S, Lian W, Li Z, Zhao JH*. Preparation and characterization of O-acylated fucosylated chondroi-tin sulfate from sea cucumber. Mar Drugs, 2012; 10, 1647–1661