张志勇 - 中国科学技术大学 - 合肥微尺度物质科学国家研究中心

个人简介

教育与科研经历 1994年9月至1998年7月就读于中国科学技术大学生物系，分子与细胞生物学学士学位 1998年9月至2003年7月在中国科学技术大学生命科学学院免试硕博连读，生化与分子生物学博士学位，获“求是”及“中国科学院院长”奖 2003年12月至2006年12月在美国得克萨斯休斯顿健康科学中心从事博士后研究，期间获得Keck Center Pharmacoinformatics Fellowship资助 2006年12月至2010年3月在犹他大学化学系从事博士后研究 2010年4月至2010年12月在芝加哥大学化学系从事博士后研究 2010年6月至今通过中国科技大学优秀人才引进，受聘为生命科学学院教授

研究领域

1. 发展生物大分子多尺度模拟的新方法，如构象空间增强采样技术和粗粒化模拟，等等； 2. 多尺度模拟整合核磁共振、冷冻电镜以及X射线小角散射等结构数据，研究生物大分子（蛋白、核酸及复合物）的结构及动态变化。

近期论文

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1. Junhui Peng#, Chuang Yuan#, Rongsheng Ma, Zhiyong Zhang*. Backmapping from multiresolution coarse-grained models to atomic structures of large biomolecules by restrained molecular dynamics simulations using Bayesian inference. Journal of Chemical Theory and Computation 2019 (15): 3344-3353 2. Zilong Wang, Shuang Wang, Zheng Xu, Mingwei Li, Kuan Chen, Yaqun Zhang, Zhimin Hu, Meng Zhang, Zhiyong Zhang*, Xue Qiao*, Min Ye*. Highly promiscuous flavonoid 3-O-glycosyltransferase from Scutellaria baicalensis. Organic Letters 2019 (21): 2241-2245 3. Chun Ye, Chengtao Ding, Rongsheng Ma, Junfeng Wang, Zhiyong Zhang*. Electrostatic interactions determine entrance/release order of substrates in the catalytic cycle of adenylate kinase. Proteins 2019 (87): 337-347 4. Difei Xu, Rongsheng Ma, Jiahai Zhang, Zhijun Liu, Bo Wu, Junhui Peng, Yanan Zhai, Qingguo Gong, Yunyu Shi, Jihui Wu, Qiang Wu, Zhiyong Zhang*, Ke Ruan*. Dynamic nature of CTCF tandem 11 zinc fingers in multivalent recognition of DNA as revealed by NMR Spectroscopy. The Journal of Physical Chemistry Letters 2018 (9): 4020-4028 5. Bin Wen, Weiwei Wang, Jiahai Zhang, Qingguo Gong, Yunyu Shi, Jihui Wu*, Zhiyong Zhang*. Structural and dynamic properties of the C-terminal region of the Escherichia coli RNA chaperone Hfq: integrative experimental and computational studies. Physical Chemistry Chemical Physics 2017 (19): 21152-21164 6. Peng Cheng#, Junhui Peng#, Zhiyong Zhang*. SAXS-oriented ensemble refinement of flexible biomolecules. Biophysical Journal 2017 (112): 1295-1301 7. Junhui Peng, Zhiyong Zhang*. Unraveling low-resolution structural data of large biomolecules by constructing atomic models with experiment-targeted parallel cascade selection simulations. Scientific Reports 2016 (6): 29360 8. Yonghui Zhang, Junhui Peng, Zhiyong Zhang*. Structural modeling of proteins by integrating small-angle X-ray scattering data. Chinese Physics B 2015 (24): 126101 9. Junhui Peng, Debiao Zhao, Bin Wen, Zhiyong Zhang*. Determining structural models of biomolecular complexes integrating nuclear magnetic resonance, small-angle X-ray scattering and computational simulations. Chinese Journal of Magnetic Resonance 2015 (32): 181-194 10. Yonghui Zhang, Bin Wen, Junhui Peng, Xiaobing Zuo, Qingguo Gong, Zhiyong Zhang*. Determining structural ensembles of flexible multi-domain proteins using small-angle X-ray scattering and molecular dynamics simulations. Protein & Cell 2015(6): 619-623 11. Zhiyong Zhang*. Systematic methods for defining coarse-grained maps in large biomolecules. Advances in Structural Bioinformatics 2015 (827): 33-48