个人简介
EDUCATION AND RESEARCH EXPERIENCE
1978.03-1982.07 Department of biology, University of Science and Technology of China; undergraduate student; speciality: Cell Biology
1982.10-1985.08 Wuhan Institute of Virology, Academia Sinica, Wuhan Assistant Researcher (Research on ds-RNA of Rota-virus and preservation technique of plant viruses)
1985.09-1988.10 Institute of Biophysics, Academia Sinica, Beijing Graduate student for Master Degree; speciality: Molecular Biology
1988.11-present School of Life Science, University of Science and Technology of China (NMR methodology, Structure determination of protein and nucleic acid)
1995.01-1996.01 Institut fuer Molekularbiologie und Biophysik, ETH, Switzerland Advanced study for NMR and Structure Determination of Protein
研究领域
NMR methodology; the conformation and dynamics property of protein and nucleic acid studied by NMR and computer simulation methods.
近期论文
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1. Yongrui Liu, Li Xu, Changlin Xie, Jingjun Hong, Fudong Li, Ke Ruan, Jiajing Chen, Jihui Wu*, Yunyu Shi*, Structural insights into ceNAP1 chaperoning activity toward ceH2A-H2B. Structure (2019) 27,1798-1810
2. Jiahai Zhang, Qiong Guo, Jun Gao, Chao Xu , Beibei Zhang, Mingwei Li, Jiaqi She, Yunyu Shi,Zhiyong Zhang, Ke Ruan* and Jihui Wu*, Structural insight into the unique dsDNA binding topology of the human ORC2 wing helix domain. The FEBS Journal (2019) 286,2726-2736
3. Xiaoling Bao, Heng Liu, Xing Liu, Ke Ruan, Yonghui Zhang, Zhiyong Zhang, Qi Hu, Ying Liu, Saima Akram, Jiahai Zhang, Qingguo Gong, Wenwen Wang, Xiao Yuan, Jian Li, Lingli Zhao, Zhen Dou, Ruijun Tian, Xuebiao Yao*, Jihui Wu*, Yunyu Shi*, Mitosis-specific acetylation tunes Ran effector binding for chromosome segregation. Journal of Molecular Cell Biology (2018), 10(1),18-32
4. Aiai Sun, Fudong Li, Zhonghua Liu, Yiyang Jiang, Jiahai Zhang, Jihui Wu*, Yunyu Shi*, Structural and biochemical insights into human zinc finger protein AEBP2 reveals interactions with RBBP4. Protein Cell (2018) 9(8),738-742
5. Pengzhi Wu, Xiaodan Liu, Lingna Yang, Yitong Sun, Qingguo Gong, Jihui Wu* and Yunyu Shi*, The important conformational plasticity of DsrA sRNA for adapting multiple target regulation. Nucleic Acids Research (2017) 45(16),9625–9639
6. Bin Wen, Weiwei Wang,Jiahai Zhang, Qingguo Gong, Yunyu Shi, Jihui Wu* and Zhiyong Zhang*, Structural and dynamic properties of the C-terminal region of the Escherichia coli RNA chaperone Hfq: integrative experimental and computational studies. Phys. Chem. Chem. Phys. (2017) 19,21152--21164
7. Qingtao Wei, Jiajing Chen, Juan Mi, Jiahai Zhang, Ke Ruan,* and Jihui Wu*, NMR Backbone Assignment of Large Proteins by Using 13Ca-Only Triple-Resonance Experiments. Chem. Eur. J. (2016) 22, 9556-9564
8. HongyuBao, FudongLi, ChongyuanWang, NaWang, YiyangJiang, YajunTang, JihuiWu*, and YunyuShi*，Structural Basis for the Specific Recognition of RhoA by the Dual GTPase-activating Protein ARAP3. Journal of Biological Chemistry (2016) 291(32),16709-16719
9. Zhonghua Liu, Fudong Li, Beibei Zhang, Sai Li, Jihui Wu# and Yunyu Shi#, Structural Basis of Plant Homeodomain Finger 6 (PHF6) Recognition by Retinoblastoma Binding Protein 4 (RBBP4) Component of the Nucleosome Remodeling and Deacetylase (NuRD) Complex. Journal of Biological Chemistry (2015) 290:6630-6638
10. Chongyuan Wang, Yuwei Zhu, Hongyu Bao, Yiyang Jiang, Chao Xu, Jihui Wu* and Yunyu Shi*, A novel RNA-binding mode of the YTH domain reveals the mechanism for recognition of determinant of selective removal by Mmi1. Nucleic Acids Research (2015) 44(2): 969-982
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