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Li-Qiang Wang#, Yeyang Ma#, Han-Ye Yuan#, Kun Zhao, Mu-Ya Zhang, Qiang Wang, Xi Huang, Wen-Chang Xu, Bin Dai, Jie Chen, Dan Li, Delin Zhang, Zhengzhi Wang, Liangyu Zou, Ping Yin, Cong Liu*, Yi Liang* (2022). Cryo-EM structure of an amyloid fibril formed by full-length human SOD1 reveals its conformational conversion. Nature Communications 13(1), 3491.
Li-Qiang Wang#, Kun Zhao#, Han-Ye Yuan#, Xiang-Ning Li, Hai-Bin Dang, Yeyang Ma, Qiang Wang, Chen Wang, Yunpeng Sun, Jie Chen, Dan Li, Delin Zhang, Ping Yin, Cong Liu*, Yi Liang* (2021). Genetic prion disease-related mutation E196K displays a novel amyloid fibril structure revealed by cryo-EM. Science Advances 7(37), eabg9676.
Li-Qiang Wang#, Kun Zhao#, Han-Ye Yuan, Qiang Wang, Zeyuan Guan, Jing Tao, Xiang-Ning Li, Yunpeng Sun, Chuan-Wei Yi, Jie Chen, Dan Li, Delin Zhang, Ping Yin, Cong Liu*, Yi Liang* (2020). Cryo-EM structure of an amyloid fibril formed by full-length human prion protein. Nature Structural & Molecular Biology 27(6), 598-602.
Ying-Ying Gao#, Tao Zhong#, Li-Qiang Wang, Na Zhang, Yan Zeng, Ji-Ying Hu, Hai-Bin Dang, Jie Chen, Yi Liang* (2022). Zinc enhances liquid-liquid phase separation of Tau protein and aggravates mitochondrial damages in cells. Int. J. Biol. Macromol. 209(Pt A), 703-715.
Bin Dai, Tao Zhong, Zhi-Xian Chen, Wang Chen, Na Zhang, Xiao-Ling Liu, Li-Qiang Wang, Jie Chen, Yi Liang* (2021). Myricetin slows liquid-liquid phase separation of Tau and activates ATG5-dependent autophagy to suppress Tau toxicity. J. Biol. Chem. 297(4), 101222.
Kan Wang#, Jia-Qi Liu#, Tao Zhong, Xiao-Ling Liu, Yan Zeng, Xinhua Qiao, Ting Xie, Yuzhe Chen, Ying-Ying Gao, Bo Tang, Jia Li, Jun Zhou, Dai-Wen Pang, Jie Chen, Chang Chen, Yi Liang* (2020). Phase separation and cytotoxicity of Tau are modulated by protein disulfide isomerase and S-nitrosylation of this molecular chaperone. J. Mol. Biol. 432(7), 2141-2163.
Jun-Jie Huang#, Xiang-Ning Li#, Wan-Li Liu, Han-Ye Yuan, Yuan Gao, Kan Wang, Bo Tang, Dai-Wen Pang, Jie Chen, Yi Liang* (2020). Neutralizing mutations significantly inhibit amyloid formation by human prion protein and decrease its cytotoxicity. J. Mol. Biol. 432(4), 828-844.
Kaixiang Zhou, Chang Yuan, Bin Dai, Kan Wang, Yimin Chen, Denglei Ma, Jiapei Dai, Yi Liang*, Hongwei Tan*, Mengchao Cui* (2019). Environment-sensitive near-infrared probe for fluorescent discrimination of Abeta and Tau fibrils in AD brain. J. Med. Chem. 62(14), 6694-6704.
Fan Yang, Kan Wang, Kaixiang Zhou, Bin Dai, Jiapei Dai, Yi Liang*, Mengchao Cui* (2019). Synthesis and bioevaluation of technetium-99 m / rhenium labeled phenylquinoxaline derivatives as Tau imaging probes. Eur. J. Med. Chem. 177, 291-301.
Wen-Chang Xu, Jin-Zhao Liang, Cheng Li, Zhi-Xin He, Han-Ye Yuan, Ben-Yan Huang, Xiao-Ling Liu, Bo Tang, Dai-Wen Pang, Hai-Ning Du, Yi Yang, Jie Chen, Lei Wang, Min Zhang*, Yi Liang* (2018). Pathological hydrogen peroxide triggers the fibrillization of wild-type SOD1 via sulfenic acid modification of Cys-111. Cell Death Dis. 9(2), 67.
Yuying Li, Kan Wang, Kaixiang Zhou, Wentao Guo, Bin Dai, Yi Liang*, Jiapei Dai, Mengchao Cui* (2018). Novel D-A-D based near-infrared probes for the detection of beta-amyloid and Tau fibrils in Alzheimer's disease. Chem. Commun. 54(63), 8717-8720.
Ji-Ying Hu, De-Lin Zhang, Xiao-Ling Liu, Xue-Shou Li, Xiao-Qing Cheng, Jie Chen, Hai-Ning Du, Yi Liang* (2017). Pathological concentration of zinc dramatically accelerates abnormal aggregation of full-length human Tau and thereby significantly increases Tau toxicity in neuronal cells. Biochim. Biophys. Acta-Mol. Basis Dis. 1863(2), 414-427.
Haibin Dang, Zhixian Chen, Wang Chen, Xudong Luo, Pan Liu, Liqiang Wang, Jie Chen, Xuhai Tang, Zhengzhi Wang, Yi Liang* (2022). The residues 4 to 6 at the N-terminus in particular modulate fibril propagation of b2-microglobulin. Acta Biochim. Biophys.Sin. 54(2), 187-198.
Xu-Dong Luo, Fan-Lou Kong, Hai-Bin Dang, Jie Chen, Yi Liang* (2016). Macromolecular crowding favors the fibrillization of beta2-microglobulin by accelerating the nucleation step and inhibiting fibril disassembly. Biochim. Biophys. Acta 1864(11), 1609-1619.
Xiao-Ling Liu, Ji-Ying Hu, Meng-Yun Hu, Yi Zhang, Zheng-Yuan Hong, Xiao-Qing Cheng, Jie Chen, Dai-Wen Pang, Yi Liang* (2015). Sequence-dependent abnormal aggregation of human Tau fragment in an inducible cell model. Biochim. Biophys. Acta-Mol. Basis Dis. 1852(8), 1561-1573.
Kai Pan, Chuan-Wei Yi, Jie Chen, Yi Liang* (2015). Zinc significantly changes the aggregation pathway and the conformation of aggregates of human prion protein. Biochim. Biophys. Acta 1854(8), 907-918.
Qian Ma, Ji-Ying Hu, Jie Chen, Yi Liang* (2013). The role of crowded physiological environments in prion and prion-like protein aggregation. Int. J. Mol. Sci. 14(11), 21414-21427.
Chuan-Wei Yi, Wen-Chang Xu, Jie Chen, Yi Liang* (2013). Recent progress in prion and prion-like protein aggregation. Acta Biochim. Biophys. Sin. 45(6). 520-526.
De-Lin Zhang, Ling-Jia Wu, Jie Chen, Yi Liang* (2012). Effects of macromolecular crowding on the structural stability of human alpha-lactalbumin. Acta Biochim. Biophys. Sin. 44(8), 703-711.
Zheng Zhou, Jun-Ming Liao, Peng Zhang, Jun-Bao Fan, Jie Chen, Yi Liang* (2011). Parkinson disease drug screening based on the interaction between D2 dopamine receptor and beta-arrestin 2 detected by capillary zone electrophoresis. Protein Cell 2(11), 899-905.
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