尤启冬 - 中国药科大学

个人简介

社会兼职:担任国家药典委员会执行委员；中国药学会理事、药物化学专业委员会委员；江苏省药学会副秘书长、常务理事、药物化学专业委员会主任委员；教育部实验教学指导委员会委员；国际药学联合会规划委员会委员，亚洲药学院校理事会理事。此外还担任《中国药科大学学报》副主编，《药学学报》、《中国药物化学杂志》等13本杂志的编委等职务；担任SCI杂志：Journal of Medcinal Chemistry编委；担任外文期刊：Chinese Journal of Pharmaceutical Sciences, Inter J Med Chem, Orphan Drugs: Research and Reviews等国际杂志的编委；担任Journal of Medicinal Chemistry, PloS ONE, Current Medicinal Chemistry, European Journal of Medicinal Chemistry, Bioorganic Medicinal Chemistry, Bioorganic Medicinal Chemistry Letter等著名国际学术杂志特约审稿人。尤启冬教授先后获教育部霍英东优秀青年教师奖、江苏省“五一劳动奖章”、“礼来亚洲杰出研究生论文导师奖”、第十一届吴阶平--保罗-杨森奖；享受国家政府特殊津贴，被评为教育部高等学校优秀骨干教师、江苏省有突出贡献的中青年专家、“高等学校教学名师”等；获省部级科技进步一等奖、二等奖等8项，国家教学成果二等奖3项、江苏省教学成果特等奖2项，获得江苏省优秀课程、教学成果奖多项。著有《药物化学》、《Chiral Drugs: Chemistry and Biological Action》、《手性药物》、《手性药物研究与评价》等著作、教材20余本。

研究领域

（1）活性天然产物的结构改造与优化（2）“蛋白-蛋白”相互作用调控剂（3）重大疾病关键调控节点的评价及药物设计等

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update. Lu MC, Ji JA, Jiang ZY, You QD. Med Res Rev. 2016 May 18. doi: 10.1002/med.21396. Palladium(II)-Catalyzed C-H Bond Activation/C-C Coupling/Intramolecular Tsuji-Trost Reaction Cascade: Facile Access to 2H-Pyranonaphthoquinones. Bian, Jinlei; Qian, Xue; Wang, Nan; Mu, Tong; Li, Xiang; Sun, Haopeng; Zhang, Lianshan; You, Qidong; Zhang, Xiaojin. Org Lett. 2015, 17 (14):3410–3413. Design, Synthesis, and Initial Evaluation of Affinity-based Small-Molecule Probes for Fluorescent Visualization and Specific Detection of Keap1. Mengchen Lu, Hai-shan Zhou, Qi-Dong You, and Zhengyu Jiang. J. Med. Chem., Just Accepted Manuscript • DOI: 10.1021/acs.jmedchem.6b00775. Structure-Activity and Structure-Property Relationship and Exploratory in vivo Evaluation of the Nanomolar Keap1-Nrf2 Protein-Protein Interaction Inhibitor.Zhengyu Jiang, Lili Xu, Mengchen Lu, Zhiyun Chen, Zhenwei Yuan, Xiaoli Xu, Xiaoke Guo, Xiaojin Zhang, Haopeng Sun, Qi-Dong You.J. Med. Chem.,2015, 58 (16):6410–6421. Discovery and Modification of in vivo active Nrf2 Activators with 1, 2, 4-oxadiazole Core: Hits Identification and Structure-Activity Relationship Study. Xu, Lili; Zhu, Junfeng; Xu, Xiaoli; Zhu, Jie; Li, Li; Xi, Meiyang; Jiang, Zhengyu; Zhang, Mingye; Liu, Fang; Lu, Mengchen; Bao, Qichao; Zhang, Chao; Wei, Jinlian; Zhang, Xiaojin; You, Qi-Dong; Sun, Haopeng. J Med Chem. 2015, 58 (14), pp 5419–5436. Discovery of potent Keap1-Nrf2 Protein-Protein Interaction Inhibitor Based on Molecular Binding Determinants Analysis. Jiang Z, Lu M, Xu L, Yang T, Xi M, Xu X, Guo X, Zhang X, You Q*, Sun H*. J Med Chem. 2014, 57:2736-2745. 3-Aroylmethylene-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-ones as Potent Nrf2/ARE Inducers in Human Cancer Cells and AOM-DSS Treated Mice. Mei-yang Xi, Jian-min Jia, Hao-peng Sun*, Zhong-ying Sun, Jie-wei Jiang, Ya-jing Wang, Min-ye Zhang, Jun-feng Zhu, Li-li Xu, Zheng-yu Jiang, Xin Xue, Ming Ye, Xi Yang, Yuan Gao, Lei Tao, Xiao-ke Guo, Xiao-li Xu, Qing-long Guo, Xiao-jin Zhang, Rong Hu*, and Qi-dong You*. J Med Chem. 2013, 56(20),7925–7938. Garcinia Xanthones as Orally Active Antitumor Agents. Zhang X, Li X, Sun H, Wang X, Zhao L, Gao Y, Liu X, Zhang S, Wang Y, Yang Y, Su Z, Guo Q, You Q*.J Med Chem. 2013, 56(1), 276-292. Novel 5-carboxy-8-HQ based histone demethylase JMJD2A inhibitors: Introduction of an additional carboxyl group at the C-2 position of quinoline. Feng T, Li D, Wang H, Zhuang J, Liu F, Bao Q, Lei Y, Chen W, Zhang X, Xu X, Sun H, You Q, Guo X.Eur J Med Chem. 2015, 105:145-155. An inhibitor of the Keap1-Nrf2 protein-protein interaction protects NCM460 colonic cells and alleviates experimental colitis. Meng-Chen Lu, Jian-Ai Ji, Yong-Lin Jiang, Zhi-Yun Chen, Zhen-Wei Yuan, Qi-Dong You & Zheng-Yu Jiang. Scientific Reports 2016, 6:26585.