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个人简介

教育背景 2007-09--2012-07 中国科学院上海有机化学研究所 博士学位 2003-10--2007-07 安徽师范大学 本科学位 工作经历 2016-03 ~ 现在 中国科学院上海有机化学研究所, 课题组长,研究员 2013-02 ~ 2016-03 美国Scripps研究所, 博士后 2012-07 ~ 2013-02 中国科学院上海有机化学研究所, 助理研究员

研究领域

受大自然精密合成机器的启发,我们寻求识别和探索关键化学转化以快速构建目标分子的核心骨架结构。这一研究的最终目标是合成一定质量的天然产物及其合成类似物(可放大合成),从而能够评估它们的生物医学潜力。 我们研究的另一个重点是开发新的合成方法来构建化学键,并在有机合成和药物发现方面具有实用和广泛的应用。

近期论文

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Xudong Wang, Ganlin Huang, Yun Wang, Jinghan Gui. Asymmetric Total Synthesis of the Rearranged Steroid Phomarol Enabled by a Biomimetic SN2′ Cyclization. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2023, 145: 9354-9363, https://doi.org/10.1021/jacs.3c02817. Yinlong Miao, Xinghui Li, Mengqing Zhang, Huafang Fan, Jinghan Gui. Synthesis of 9,11-Secosteroids Pinnisterol E, Glaciasterol B, and 6-Keto-aplidiasterol B. Organic Letters[J]. 2022, 24(8): 1684-1688, https://pubs.acs.org/doi/10.1021/acs.orglett.2c00281. Zhang, Mengqing, Fan, Huafang, Wang, Yun, Gui, Jinghan. Total Synthesis of the Phenolic Steroid Myrmenaphthol A. ORGANIC LETTERS[J]. 2022, 24(40): 7383-7387, http://dx.doi.org/10.1021/acs.orglett.2c02910. Yao Liangcai, Gui Jinghan. Application of the Radical Polyene Cyclization Reaction in Natural Product Synthesis. CHINESE JOURNAL OF ORGANIC CHEMISTRYnull. 2022, 42(9): 2703-2714, Yang, Peicheng, Li, YanYu, Tian, Hailong, Qian, GanLu, Wang, Yun, Hong, Xin, Gui, Jinghan. Syntheses of Bufospirostenin A and Ophiopogonol A by a Conformation-Controlled Transannular Prins Cyclization. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2022, 144: 17769-17775, Ning, Yuhan, Tian, Hailong, Gui, Jinghan. Biogenesis-Guided Synthesis and Structural Revision of Sarocladione Enabled by Ruthenium-Catalyzed Endoperoxide Fragmentation. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2021, 60(20): 11222-11226, http://dx.doi.org/10.1002/anie.202101451. Li, Xinghui, Zhang, Zeliang, Fan, Huafang, Miao, Yinlong, Tian, Hailong, Gu, Yucheng, Gui, Jinghan. Concise Synthesis of 9,11-Secosteroids Pinnigorgiols B and E. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2021, 143(13): 4886-4890, http://dx.doi.org/10.1021/jacs.0c13426. Yu Wang, Hailong Tian, Jinghan Gui. Gram-Scale Synthesis of Bufospirostenin A by a Biomimetic Skeletal Rearrangement Approach. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2021, 143(46): 19576-19586, https://pubs.acs.org/doi/10.1021/jacs.1c10067. Ju, Wei, Wang, Xudong, Tian, Hailong, Gui, Jinghan. Asymmetric Total Synthesis of Clionastatins A and B. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2021, 143(33): 13016-13021, http://dx.doi.org/10.1021/jacs.1c07511. Deng, Jiachen, Ning, Yuhan, Tian, Hailong, Gui, Jinghan. Divergent Synthesis of Antiviral Diterpenes Wickerols A and B. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2020, 142(10): 4690-4695, https://www.webofscience.com/wos/woscc/full-record/WOS:000526392200025. Wang, Yu, Chen, Bo, He, Xubiao, Gui, Jinghan. Development of Biomimetic Synthesis of Propindilactone G. CHINESE JOURNAL OF CHEMISTRY[J]. 2020, 38(11): 1339-1352, http://lib.cqvip.com/Qikan/Article/Detail?id=7103703748. Bao, Jiajing, Tian, Hailong, Yang, Peicheng, Deng, Jiachen, Gui, Jinghan. Modular Synthesis of Functionalized Butenolides by Oxidative Furan Fragmentation. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY[J]. 2020, 2020(3): 339-347, https://www.webofscience.com/wos/woscc/full-record/WOS:000506932600001. Wang, Yu, Chen, Bo, He, Xubiao, Gui, Jinghan. Bioinspired Synthesis of Nortriterpenoid Propindilactone G. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2020, 142(11): 5007-5012, https://www.webofscience.com/wos/woscc/full-record/WOS:000526392600011. Deng, Jiachen, Gui, Jinghan. Alkyne-Forming Furan Fragmentation: A General Method to Convert Furans into Alkynoic Acids. SYNLETT[J]. 2019, 30(6): 642-646, Wang, Yu, Ju, Wei, Tian, Hailong, Sun, Suyun, Li, Xinghui, Tian, Weisheng, Gui, Jinghan. Facile Access to Bridged Ring Systems via Point-to-Planar Chirality Transfer: Unified Synthesis of Ten Cyclocitrinols. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2019, 141(12): 5021-5033, Deng, Jiachen, Wu, Jingjing, Tian, Hailong, Bao, Jiajing, Shi, Yong, Tian, Weisheng, Gui, Jinghan. Alkynes From Furans: A General Fragmentation Method Applied to the Synthesis of the Proposed Structure of AglatominB. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2018, 57(14): 3617-3621, https://www.webofscience.com/wos/woscc/full-record/WOS:000428350100011. Wang, Yu, Ju, Wei, Tian, Hailong, Tian, Weisheng, Gui, Jinghan. Scalable Synthesis of Cyclocitrinol. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2018, 140(30): 9413-9416, https://www.webofscience.com/wos/woscc/full-record/WOS:000440877000020. Lo, Julian C, Kim, Dongyoung, Pan, ChungMao, Edwards, Jacob T, Yabe, Yuki, Gui, Jinghan, Qin, Tian, Gutierrez, Sara, Giacoboni, Jessica, Smith, Myles W, Holland, Patrick L, Baran, Phil S. Fe-Catalyzed C-C Bond Construction from Olefins via Radicals. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2017, 139(6): 2484-2503, https://www.webofscience.com/wos/woscc/full-record/WOS:000394482200052. Gui, Jinghan, Pan, ChungMao, Jin, Ying, Qin, Tian, Lo, Julian C, Lee, Bryan J, Spergel, Steven H, Mertzman, Michael E, Pitts, William J, La Cruz, Thomas E, Schmidt, Michael A, Darvatkar, Nitin, Natarajan, Swaminathan R, Baran, Phil S. Practical olefin hydroamination with nitroarenes. SCIENCE[J]. 2015, 348(6237): 886-891, https://www.webofscience.com/wos/woscc/full-record/WOS:000354877900038. Gui, Jinghan, Wang, Yun, Tian, Hailong, Gao, Yuqi, Tian, Weisheng. Perfluoroalkylsulfonyl fluoride-mediated abnormal Beckmann rearrangement of steroid 17-oximes with acid-labile groups. TETRAHEDRON LETTERS[J]. 2014, 55(30): 4233-4235, http://dx.doi.org/10.1016/j.tetlet.2014.06.005. Lo, Julian C, Gui, Jinghan, Yabe, Yuki, Pan, ChungMao, Baran, Phil S. Functionalized olefin cross-coupling to construct carbon-carbon bonds. NATURE[J]. 2014, 516(7531): 343-348, https://www.webofscience.com/wos/woscc/full-record/WOS:000346484800036. Gui, Jinghan, Zhou, Qianghui, Pan, ChungMao, Yabe, Yuki, Burns, Aaron C, Collins, Michael R, Ornelas, Martha A, Ishihara, Yoshihiro, Baran, Phil S. C-H Methylation of Heteroarenes Inspired by Radical SAM Methyl Transferase. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2014, 136(13): 4853-4856, https://www.webofscience.com/wos/woscc/full-record/WOS:000333947900015.

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