Yu, Huazhong - Simon Fraser University - Department of Chemistry

个人简介

B. Sc. & M.Sc. - Shandong University Ph. D. - Peking University (Beijing) Postdoctoral Fellow - California Institute of Technology Postdoctoral Fellow - NRC Steacie Institute for Molecular Sciences

研究领域

Bioanalytical Chemistry and Physical Chemistry The research work conducted in my group at Simon Fraser University spans a broad range of analytical, physical, and materials chemistry. In particular, we are interested in surface modification with self-assembled monolayers, fabrication/characterization of nanostructured materials, and development of biosensing devices. Active projects include: DNA surface chemistry and aptamer-based electronic biosensors. A thorough understanding of DNA surface chemistry is critical to the fabrication of DNA microarrays for high-throughput gene analysis and of aptamer (nucleic acid receptor)-based biosensors for ultrasensitive protein detection. We have developed an electrochemical method that is simple and versatile for quantifying DNA-modified surfaces, which also allowed detailed investigations of cation / DNA interactions on surface. We have been exploring chip-based methodologies for measuring the electrochemical signals induced in “deoxyribosensors” (rationally designed DNA conformational switches using aptamer sequences) upon analyte binding. These synthetic DNA-based biosensors have considerable commercial potential as replacement of animal-produced antibody probes for near-patient clinical testing. Disc-based bioanalytical and materials chemistry. We previously invented a method for using compact discs (CD) as inexpensive, high-quality gold substrates suitable for the preparation of self-assembled monolayers and fabrication of electrode microarrays. We also developed an efficient protocol to activate the plastic CD base as biochip substrate (e.g., microfluidic DNA microarrays), which leads to the success of reading disc-based bioassays with standard optical drives of ordinary laptop/desktop computers. In addition, our demonstration of “templated” electrodeposition of inorganic oxide thin films on micropatterned CD-R substrates is a prime example of innovation in research that has significant potential for practical applications. Molecular modification of semiconductors and electrical characterization. Our method of silicon surface modification with Si-C bonded monolayers and the systematic characterization by various analytical techniques has won us a leading position in this rapidly developing field. In particular, we took an important step of directly measuring the electrical properties of organic monolayers on silicon with a non-invasive Hg electrode, and observed molecular rectification behaviors.This work represents a new route toward functional nanoscale electronic devices. Since silicon as electrode material is compatible with existing microelectronic technologies, DNA biosensors may be fabricated in the same manner as computer chips in the future.

近期论文

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Superhydrophobic substrates from off-the-shelf laboratory filter paper: simplified preparation, patterning, and assay application, Zhang, L.; Kwok, H.; Li, X.; Yu, H.-Z., ACS Appl. Mater. Interfaces, 2017;9(45):39728-39735. Integrated smartphone-app-chip system for on-site ppb-level colorimetric quantitation of aflatoxins, Li, X.; Yang, F.; Wong, J. X. H.; Yu, H.-Z. Anal. Chem. 2017;89(17):8908-8916. Plastic fingerprint replica: solvent-assisted 3D molding and motion-promoted nano-spherulite formation, Schultz, C. W.; Wong, J. X. H.; Yu, H-Z.; Can. J. Chem. 2017, in press (June 24, 2017; SFU special issue). A non-linear harmonic analysis of potential induced fluorescence modulation of a DNA self-assembled monolayer, Yu, Z. L.; Leung, K. K.; Yu, H.-Z.; Bizzotto, D. Electrochim. Acta 2017, 245, 386–394. Host-Guest Interaction at Molecular Interfaces: Binding of Cucurbit[7]uril on Ferrocenyl Self-Assembled Monolayers on Gold, Qi, L.; Tian, H.; Shao, H.; Yu, H.-Z., J. Phys. Chem. C 2017, 121, 7985–7992. Revealing and resolving the restrained enzymatic cleavage of DNA self-assembled monolayers on gold: electrochemical quantitation and ESI-MS confirmation, Gao, X.; Geng, M.; Li, Y.; Wang, X.; Yu, H.-Z., Anal. Chem. 2017, 89, 2464–2471. Digitized molecular detection on off-the-shelf Blu-ray discs: upgraded resolution and enhanced Sensitivity, Shi, M.; Weng, S.; Li, X.; Yu, H.-Z. Sens. Actuators B 2017, 242, 79–86. Optical disc technology-enabled analytical devices: from hardware modification to digitized molecular detection, Weng, S.; Li, X.; Li, Y.; Yu, H.-Z. Analyst 2016, 141, 6190-6201 (Tutorial Review, cover picture). Blu-ray Technology-Based Quantitative Assays for Cardiac Markers: From Disc Activation to Multiplex Detection, Weng, S.; Li, X.; Niu, M.; Ge, B.; Yu, H.-Z. Anal. Chem. 2016, 88, 6889–6896 (cover picture). Facile Preparation of Nanostructured, Superhydrophobic Filter Paper for Efficient Water/Oil Separation, Wang, J.; Wong, J.X.H.; Kwok, H.; Li, X.; Yu, H.-Z., PLoS ONE 2016, 11, e0151439(1-12). DNA-Redox Cation Interaction Improves the Sensitivity of an Electrochemical Immunosensor for Protein Detection, Li, P.; Ge, B.; Ou, L.M.-L.; Yao, Z.; Yu, H.-Z. Sensors 2015, 15, 20543-20556 (invited feature article). Direct Reading of bona fide barcode assays for diagnostics with smartphone apps, Wong, J. X. H.; Li, X.; Liu, F. S. F.; Yu, H.-Z. Sci. Rep. 2015, 5, 11727 (1-11). Smartphone-readable barcode assay for the detection and quantitation of pesticide residues, Guo, J.; Wong, J. X. H.; Li, X.; Cui, C.; Yu, H.-Z. Analyst 2015, 140, 5518 - 5525 (cover picture). Detection and quantitation of heavy metal ions on bona fide DVDs using DNA molecular beacon probes, Zhang, L.; Wong, J. X. H.; Li, X.; Li, Y.; Yu, H.-Z. Anal. Chem. 2015, 87, 5062–5067. Homogenized redox behavior of electroactive self-assembled monolayers on gold in the organic phase, Tian, H.; Qi, L.; Xiang, D.; Shao, H.; Yu, H.-Z. Electrochim. Acta 2015, 170, 369–375. On-site chip-based colorimetric quantitation of organophosphorus pesticides using an office scanner, Meng, X.; Schultz, C. W.; Cui, C.; Li, X.; Yu, H.-Z., Sen. Actuators B 2015, 215, 577-583. Binary DNA hairpin-based colorimetric biochip for simultaneous detection of Pb2+ and Hg2+ in real-world samples, Shi, X.; Gao, X.; Zhang, L.; Li, Y.; Fan, L.; Yu, H.-Z. Analyst 2015, 140, 2608–2612 Metastable Molecular Metal-Semiconductor Junctions, Zhu, L.; Popoff, R. T. M.; Yu, H.-Z. J. Phys. Chem. C 2015, 119, 1826–1831. Indirect Competitive Assays on DVD for Direct Multiplex Detection of Drugs of Abuse in Oral Fluids, Zhang, L.; Li, X.; Li, Y.; Shi, X.; Yu, H.-Z. Anal. Chem. 2015, 87, 1896–1902. DNA mechatronic devices switched by K+ and by Sr2+ are structurally, topologically and electronically distinct, Huang, Y. C.; Yu, H.-Z.; Sen, D. Biopolymers 2015, 103, 460-468.