娄筱叮 - 中国地质大学(武汉)

个人简介

教育经历 2007/9 - 2012/6，武汉大学，有机化学，博士，导师：李振教授 2004/9 - 2007/6，武汉大学，化学基地班，交流生 2003/9 - 2004/6，湖北工程学院，化学教育学,学士工作经历 2017/1-至今，中国地质大学(武汉)，材料与化学学院，教授 2016/4-2016/10，加州大学圣塔芭芭拉分校，物理系，访问学者，合作导师：Alan J. Heeger教授（2000年诺贝尔奖得主） 2014/11-2016/12，华中科技大学，化学与化工学院，副教授 2013/8-2014/10，华中科技大学，化学与化工学院，讲师 2012/8-2013/7，香港科技大学，高分子系，Research Associate，合作导师：唐本忠教授

研究领域

娄筱叮教授长期以来围绕复杂生物样本，在多功能聚集体设计及应用方面取得了创新性成果：1) 空间维度上，针对多细胞器异质性等问题，提出逐级递送多肽/聚集基元组装新策略；2) 效率维度上，针对肿瘤易转移等问题，发展多基元先共价结合再刺激分离的“一分为N”新方法；3) 时间维度上，针对不同细胞周期肿瘤标志物表达差异，开发同步后分析的端粒酶分周期提取及检测新技术。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Wu, Xia, Wu, Jun, Dai, Jun, Chen, Biao, Chen, Zhe, Wang, Shixuan, Wu, Feng, Lou, Xiaoding(*), Xia, Fan, Role of cell cycle progression on analyzing telomerase in cancer cells based on aggregation-induced emission luminogens. National Science Review 2021; DOI: 10.1093/nsr/nwaa306. Yi, Xiaoqing(#), Hu, Jing-Jing(#), Dai, Jun, Lou, Xiaoding(*), Zhao, Zujin, Xia, Fan(*), Tang, Ben Zhong(*), Self-Guiding Polymeric Prodrug Micelles with Two Aggregation-Induced Emission Photosensitizers for Enhanced Chemo-Photodynamic Therapy, ACS Nano, 2021, 15, 3026-3037. Yang, Juliang(#), Dai, Jun(#), Wang, Quan, Cheng, Yong, Guo, Jingjing, Zhao, Zujin, Hong, Yuning, Lou, Xiaoding(*) and Xia, Fan, Tumor Triggered Disassembly of Multiple‐Agent‐Therapy Probe for Efficient Cellular Internalization, Angewandte Chemie International Edition, 2020, 59, 20405-20410. Dai, Jun(#),Cheng, Yong(#),Wu, Jun(#), Wang Quan, Wang Wenwen, Yang, Juliang, Zhao, Zujin, Lou, Xiaoding(*), Xia, Fan(*), Wang, Shixuan(*), Tang, Ben Zhong, Modular peptide probe for pre/intra/postoperative therapeutic to reduce recurrence in ovarian cancer. ACS Nano 2020, 14: 14698-14714. Dai, Jun(#), Li, Yinghao(#), Long, Zi, Jiang, Ruming, Zhuang, Zeyan, Wang, Zhiming, Zhao, Zujin(*), Lou, Xiaoding(*), Xia, Fan and Tang, Ben Zhong(*), Efficient near-infrared photosensitizer with aggregation-induced emission for imaging-guided photodynamic therapy in multiple xenograft tumor models, ACS Nano, 2020, 14, 854-866. Lou, Xiaoding(#), Huang, Yu (#), Yang, Xian, Zhu, Hai, Heng, Liping, and Xia, Fan(*), External Stimuli Responsive Liquid-Infused Surfaces Switching between Slippery and Non-slippery States: Fabrications and Applications, Advanced Functional Materials, 2020, 30, 1901130. IF= 16.836; Times Cited: 10 Xia, Fan, Wu, Jun, Wu, Xia, Hu, Qinyu, Dai, Jun, Lou, Xiaoding(*), Modular design of peptide- or DNA-modified AIEgens probes for biosensing applications, Accounts of Chemical Research, 2019, 52, 3064-3074. Cheng, Yong(#), Sun, Chunli(#), Liu, Rui(#), Yang, Juliang, Dai, Jun, Zhai, Tianyou, Lou, Xiaoding(*), Xia, Fan(*), A multifunctional peptide-conjugated AIEgen for efficient and sequential targeted gene delivery into the nucleus, Angewandte Chemie International Edition, 2019, 58, 5049-5053. Wu, Feng(#), Wu, Xia(#), Duan, Zhijuan, Huang, Yu, Lou, Xiaoding(*) and Xia, Fan(*), Biomacromolecule-Functionalized AIEgens for Advanced Biomedical Studies, Small, 2019, 1804839. Lou, Xiaoding(#), Song, Yongjun(#), Liu, Rui, Cheng, Yong, Dai, Jun, Chen, Qing, Gao, Pengcheng, Zhao, Zujin and Xia, Fan (*) Enzyme and AIEgens Modulated Solid-State Nanochannels: In Situ and Noninvasive Monitoring of H2O2 Released from Living Cells, Small Methods, 2019, 1900432. Hu, Rong, Chen, Bin, Wang, Zhiming, Qin, Anjun, Zhao, Zujin(*), Lou, Xiaoding(*) and Tang, Ben Zhong(*), Intriguing "chameleon" fluorescent bioprobes for the visualization of lipid droplet-lysosome interplay, Biomaterials, 2019, 203, 43-51. Zhen, Shijie(#), Yi, Xiaoqing(#), Zhao, Zujin(*), Lou, Xiaoding(*), Xia, Fan and Tang, Ben Zhong(*), Drug delivery micelles with efficient near-infrared photosensitizer for combined image-guided photodynamic therapy and chemotherapy of drug-resistant cancer, Biomaterials, 2019, 119330. Cheng, Yong(#), Dai, Jun(#), Sun, Chunli(#), Liu, Rui, Zhai, Tianyou, Lou, Xiaoding(*), Xia, Fan(*), An intracellular H2O2-responsive AIEgen for the peroxidase-mediated selective imaging and inhibition of inflammatory cells, Angewandte Chemie International Edition, 2018, 57, 3123-3127. Wang, Xudong(#), Dai, Jun(#), Min, Xuehong, Yu, Zhihua, Cheng, Yong, Huang, Kaixun, Yang, Juliang, Yi, Xiaoqing, Lou, Xiaoding (*), Xia, Fan(*), DNA-Conjugated Amphiphilic Aggregation-Induced Emission Probe for Cancer Tissue Imaging and Prognosis Analysis, Analytical Chemistry, 2018, 90, 8162-8169. Cheng, Yong, Sun, Chunli, Ou, Xiaowen, Liu, Bifeng, Lou, Xiaoding(*), and Xia, Fan(*), Dual-targeted peptide-conjugated multifunctional fluorescent probe with AIEgen for efficient nucleus-specific imaging and long-term tracing of cancer cells, Chemical Science, 2017, 8, 4571-4578. Zhuang, Yuan(#), Shang, Chunli(#), Lou, Xiaoding(*), Xia, Fan(*), Construction of AIEgens-based bioprobe with two fluorescent signals for enhanced monitor of extracellular and intracellular telomerase activity, Analytical Chemistry, 2017, 89, 2073-2079. Duan, Ruixue, Lou, Xiaoding(*), Xia, Fan(*), The development of nanostructure assisted isothermal amplification in biosensors, Chemical Society Reviews, 2016, 45, 1738-1749. Gao, Pengcheng, Hu, Lintong, Liu, Nannan, Yang, Zekun, Lou, Xiaoding(*), Zhai, Tianyou(*), Li, Huiqiao, Xia, Fan(*), Functional “janus” annulus in confined channels, Advanced Materials, 2016, 28, 460-465. Zhuang, Yuan, Huang, Fujian, Xu, Qi, Zhang, Mengshi, Lou, Xiaoding(*), Xia, Fan, Facile, Fast-responsive and photostable imaging of telomerase activity in living cells with a fluorescence turn-on manner, Analytical Chemistry, 2016, 88, 3289-3294. Jia, Yongmei(#), Gao, Pengcheng(#), Zhuang, Yuan(#), Miao, Mao, Lou, Xiaoding(*), Xia, Fan, Facile probe design: fluorescent amphiphilic nucleic acid probes without quencher providing telomerase activity Imaging inside living cells, Analytical Chemistry, 2016, 88, 6621-6626.