Marek, Ilan - Technion - Israel Institute of Technology - The Mallat Family Laboratory of Organic Chemistry

个人简介

Prof. Marek has received several awards for his research, including the First French Chemical Society-Acros Price for young Organic Chemist (under 40 years old in 1997); the Japan Society for the Promotion of Science Visiting Professor Award (1997); the Lawrence G. Horowitz Career Development Chair (1998); the Yigal Alon Fellowship (1998); Evelyn and Salman Grand Academic Lectureship-USA (1998); the Yosefa and Leonid Allschwang award, administrated by the Israel Science Foundation (2000); the Michael Bruno Memorial Award 2002, administrated by the Rothschild Foundation (2002); the Prize for Excellent Young Chemist, The Israel Chemical Society (2004); the Merck Sharpe and Dohm Lecturer (2005); the Bessel Award of the Humboldt Foundation, Germany (2007), the Taub Award for academic excellence (2009), The German-Technion Award for Academic Excellence and Scientific Collaborations, (2010), the Royal Society Chemistry organometallic Award from the RSC (2011), the Taiwan National Science Council Visiting Scholar (2011), the Janssen Pharmaceutica Prize for Creativity in Organic Synthesis (2012), the Israel Chemical Society Award for Excellence (2012), the Moore Distinguished Scholar Appointment at the California Institute of Technology (2013), the Eli Lilly lecturer at Urbana Champaign, Il, USA (2014), the SFB-guest Professor Wilhelms-University Munster, Germany (2015), the Joseph and Patricia Vanderslice Lecturer, Boston College (2015), the 17th International Organic Chemistry Foundation Yoshida Lectureship, Japan (2015), the Weizmann Prize for Exact Sciences (2015) and the YannaiAward for excellence in teaching (2016). 2019/10 Visiting Professor University of Ottawa, Canada 2015/9-2015/10 Visiting Professor Osaka Prefecture University, Osaka, Japan 2013/8-2013/10 Distinguished Moore Scholar Visiting Professor California Institute of Technology (CalTech), Pasadena, California 2011/2-2011/3 Visiting professor at Ecole Nationale Superieure de Chimie de Montpellier,France 2010/8-2010/9 Visiting Professor California Institute of Technology (CalTech), Pasadena,California 2010/02 Visiting Professor Universite Paris-Descartes, Paris V, France 2007/10 Visiting Professor Universite Louis Pasteur, Strasbourg, France 2006/3-2006/7 Visiting Professor University de Montreal, Montreal, Quebec, Canada 2005 Holder of a chair: Sir Michael and Lady Sobell Academic Chair 2004 Full Professor, Department of Chemistry, Technion-Israel Institute of Technology 2000 Associate Professor, Department of Chemistry, Technion-Israel Institute of Technology (tenured position) 1997 Senior Lecturer, Department of Chemistry, Technion-Israel Institute of Technology. 1994 Charge de recherche: First class at the CNRS (National Center for Scientific Research) Universite Pierre-et-Marie Curie, Paris, France (tenured position). 1990 Independant Research Position as Charge de recherche at the CNRS (National Center for Scientific Research). Universite Pierre-et-Marie Curie, Paris, France. 1989 Post-doctoral position in Professor Ghosez laboratory (Louvain-la-Neuve,Belgium)

研究领域

We are concerned with the design and development of new and efficient stereo- and enantioselective strategies for the synthesis of important complex molecular structures. We are particularly interested in developing carbon-carbon bond forming processes, which efficiently create multiple stereocenters in a single-pot operation. Deep understanding of reaction mechanisms gives insight into the origins of chemo- and stereoselectivity, and governs optimization towards the most efficient and general protocols for our methodologies. Our vision is that we should provide an answer to challenging synthetic problems but it has to be coupled with unique efficiency and elegance.

近期论文

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Alkene Isomerization through Allylmetals as a Strategic Tool in Stereoselective Synthesis Itai Massad and Ilan Marek 2020 ACS Catal. 2020, 10, 5793−5804 Nucleophilic Substitution at Quaternary Carbon Stereocenters Veeranjaneyulu Lanke and Ilan Marek 2020 J. Am. Chem. Soc. 2020, 142, 5543-5548 Corrections: J. Am. Chem. Soc. 2020, 142, 7710-7712 Pd-Catalyzed Enantioselective Hydroalkynylation of Cyclopropenes Longyang Dian and Ilan Marek 2020 ACS Catalysis, 2020, 10, 1289-1293 Enantioselective Synthesis of Vicinal Tertiary and Quaternary Carbon Stereogenic Centers Within an Acyclic Chain David Pierrot and Ilan Marek 2020 Angew. Chem. Int. Ed. 2020, 59, 36-49 Catalytic Enantioselective Cyclopropenation of Internal Alkynes: Access to Difluoromethylated Three-Membered Carbocycles Zhi-Qi Zhang, Meng-Meng Zheng, Xiao-Song Xue, Ilan Marek, Fa-Guang Zhang, Jun-An Ma 2019 Angew. Chem. Int. Ed. 2019, 58, 18191-18196 Diastereoselective Ring Opening of Fully-Substituted Cyclopropanes via Intramolecular Friedel–Crafts Alkylation Veerujaneyulu Lanke, Fa-Guang Zhang, Alexander Kaushansky and Ilan Marek 2019 Chem. Science 2019, 10, 9548-9554 Regio- and Stereoselective Synthesis of Fully Substituted Silyl Enol Ethers of Ketones and Aldehydes in Acyclic Systems. Peter-Yong Wang, Guillaume Duret and Ilan Marek 2019 Angew. Chem. Int. Ed. 2019, 58, 14995-14999 Regio- and Diastereoselective Copper-Catalyzed Carbometalation of Cyclopropenylsilanes Yair Cohen and Ilan Marek 2019 Organic Letters 2019, 21, 9162-9165 Highly E-selective, Stereoconvergent Nickel-Catalyzed Suzuki-Miyaura Cross-Coupling of Alkenyl Ethers Guo-Ming Ho, Heiko Sommer and Ilan Marek 2019 Org. Lett 2019, 21, 2913-2917 A Tandem Iridium-catalyzed ‘Chain-walking’/Cope Rearrangement Sequence Heiko Sommer, Tal Weissbrod and Ilan Marek 2019 ACS Catalysis, 2019, 9, 2400-2406 Diastereo- and Enantioselective Preparation of Cyclopropanol and Cyclopropylamine Derivatives Marwan Simaan and Ilan Marek 2019 Beilstein Journal of Organic Chemistry, 2019, 15, 752-760 Versatility in the Brook Rearrangement for Selective Ring-Opening of Three-Membered Rings Coralie Tugny, Fa-Guang Zhang and Ilan Marek Coralie Tugny, Fa-Guang Zhang and Ilan Marek 2019 Chem. Eur. J. 2019, 25, 205-209 Convergent and Flexible Approach to Stereodefined Polyhydroxylated Fragments Alexander Shtrenberg, Elvira Haimov, Polina Smirnov and Ilan Marek 2018 Tetrahedron (special issue for Prof. Leon Ghosez), 2018, 74, 6761-6768 Diastereoselective Ring Opening of Alkenylcyclopropanes: Application to the Total Synthesis of C30 Botryococcene and epi-Botryococcene Morgan Cormier, Aurelien de la Torre and Ilan Marek 2018 Angew. Chem. Int. Ed. 2018, 58, 13237-13241. Efficient and Stereodivergent Synthesis of Unsaturated Acyclic Fragments Bearing Contiguous Stereogenic Elements Jeffrey Bruffaerts, David Pierrot and Ilan Marek 2018 Nature Chemistry, 2018, 10, 1164-1170 Asymmetric Preparation of Polysubstituted Cyclopropanes Based on Direct Functionalization of Achiral Three-Membered Carbocycles Longyang Dian and Ilan Marek 2018 Chemical Reviews (Focus) 2018, 118, 8415-8434 Diastereo- and Enantioselective Copper Catalyzed Hydroallylation of Disubstituted Cyclopropenes Heiko Sommer and Ilan Marek 2018 Chemical Science 2018, 9, 6503-6508 Pd-Catalyzed Selective Remote Ring-Opening of Polysubstituted Cyclopropanols Sukhbev Singh, Marwan Simaan and Ilan Marek 2018 Chem. Eur. J. 2018, 24, 8553-8557 Metal-Catalyzed Remote Functionalization of -Ene Unsaturated Ethers as a New Entry to Functionalized Vinyl Species Guo-Ming Ho, Lina Jiudkele, Jeffrey Bruffaerts and Ilan Marek 2018 Angew. Chem. Int. Ed. 2018, 57, 57, 8012-8016 Asymmetric Rh-Catalyzed Arylation of Cyclopropenes Based on Directed Functionalization of Three-Membered Carbocycles (DFTMC) Longyang Dian and Ilan Marek 2018 Angew. Chem. Int. Ed. 2018, 57, 3682-3686