瑕瑜 - 清华大学

个人简介

Dr. Yu Xia earned her B.S. (1999) in Chemistry from Lanzhou University, China, M.S. (2002) from Shanghai Institute of Material Medical, CASs, China, and Ph.D. (2006) under the supervision of Professor Scott A. McLuckey from Purdue University, USA. After postdoctoral training with Prof. Graham R. Cooks at Purdue, Dr. Xia took positions as Assistant Professor and Associate Professor at the Department of Chemistry, Purdue University. She is currently a Professor at the Department of Chemistry, Tsinghua University, Beijing, China. Dr. Xia utilizes radical reactions as a unique approach to achieve enhanced bioanalysis via mass spectrometry. In particular, her recent research emphasizes on developing lipidomic tools capable of resolving structural isomers. Her work has resulted in over 90 peer-reviewed publications and book chapters. Dr. Xia received ASMS Research Award (2013) and served as Secretary of ASMS from 2015-2017. She is currently on the editorial board of the Journal of the American Society of Mass Spectrometry.

研究领域

Gas-phase radical ion chemistry Radical ions, which consist of unpaired electrons, offer distinct gas-phase ion chemistry as compared to the even-electron species. Radical chemistry can be utilized to tackle challenging problems, such as differentiating isomeric structures, which would otherwise not be solved by traditional MS analysis of even-electron ions of the biomolecules. We are developing MS instrumentation and methods to facilitate radical reactions for either in the vacuum or in ambient air. 1. Radical reactions at the interface of ESI-MS 2. Ion/radical reactions in a linear ion trap mass spectrometer 3. Chemistry of bio-radical ions 4. Application of radical chemistry for bio-analysis Analysis of unsaturated lipids

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Exosomal lipid PI4P regulates small extracellular vesicle secretion by modulating intraluminal vesicle formation 2023. Journal of Extracellular Vesicles. Xue Jin · Tian Xia · Shuchen Luo · Ying Zhang · Yu Xia · Hang Yin Visible-Light Paternò–Büchi Reaction for Lipidomic Profiling at Detailed Structure Levels 2023. Analytical Chemistry. Hengxue Shi · Zhenshu Tan · Xiangyu Guo · Hanlin Ren · Shengzhuo Wang · Yu Xia A Cleavable Self-Inclusion Conjugate with Enhanced Biocompatibility and Antitumor Bioactivity 2022. CCS Chemistry. Han Wu · Tian Xia · Feilong Qi · Shan Mei · Yu Xia · Jiang-Fei Xu · Xi Zhang Bio-inspired lanthanum-ortho-quinone catalysis for aerobic alcohol oxidation: semi-quinone anionic radical as redox ligand 2022. Nature Communications. Ruipu Zhang · Runze Zhang · Ruijun Jian · Long Zhang · Ming-Tian Zhang · Yu Xia · Sanzhong Luo Deep-lipidotyping by mass spectrometry: recent technical advances and applications 2022. Journal of Lipid Research. Wenpeng Zhang · Ruijun Jian · Jing Zhao · Yikun Liu · Yu Xia Development of a Miniature Mass Spectrometry System for Point-of-Care Analysis of Lipid Isomers Based on Ozone-Induced Dissociation 2022. Analytical Chemistry. Xinwei Liu · Bin Jiao · Wenbo Cao · Xiaoxiao Ma · Yu Xia · Stephen J. Blanksby · Wenpeng Zhang · Zheng Ouyang Inhibition of cannabinoid receptor type 1 sensitizes triple-negative breast cancer cells to ferroptosis via regulating fatty acid metabolism 2022. Cell Death and Disease. Pengyun Li · Qiaohong Lin · Shiyang Sun · Ning Yang · Yu Xia · Shengjie Cao · Wenjuan Zhang · Qian Li · Haoxin Guo · Maoxiang Zhu · Yilong Wang · Zhibing Zheng · Song Li Introducing the Lipidomics Minimal Reporting Checklist 2022. Nature Metabolism. Jeffrey G. Mcdonald · Christer S. Ejsing · Dominik Kopczynski · Michal Holčapek · Junken Aoki · Makoto Arita · Masanori Arita · Erin S. Baker · Justine Bertrand-Michel · John A. Bowden · Britta Brügger · Shane R. Ellis · Maria Fedorova · William J. Griffiths · Xianlin Han · Jürgen Hartler · Nils Hoffmann · Jeremy P. Koelmel · Harald C. Köfeler · Todd W. Mitchell · Valerie B. O’Donnell · Daisuke Saigusa · Dominik Schwudke · Andrej Shevchenko · Candice Z. Ulmer · Markus R. Wenk · Michael Witting · Denise Wolrab · Yu Xia · Robert Ahrends · Gerhard Liebisch · Kim Ekroos LipidOA: A Machine-Learning and Prior-Knowledge-Based Tool for Structural Annotation of Glycerophospholipids 2022. Analytical Chemistry. Donghui Zhang · Qiaohong Lin · Tian Xia · Jing Zhao · Wenpeng Zhang · Zheng Ouyang · Yu Xia Localization of Intrachain Modifications in Bacterial Lipids Via Radical-Directed Dissociation 2022. Journal of the American Society for Mass Spectrometry. Qiaohong Lin · Pengyun Li · Ruijun Jian · Yu Xia Profiling of branched-chain fatty acids via nitroxide radical-directed dissociation integrated on an LC-MS/MS workflow 2022. The Analyst. Ruijun Jian · Xue Zhao · Qiaohong Lin · Yu Xia Pyridine dicarbanion-bonded Ag₁₃ organometallic nanoclusters: synthesis and on-surface oxidative coupling reaction 2022. Chemical Science. Cui-Cui Li · Siqi Zhang · Jian Tang · Ruijun Jian · Yu Xia · Liang Zhao Site-Specific Photochemical Reaction for Improved C=C Location Analysis of Unsaturated Lipids by Ultraviolet Photodissociation 2022. Research. Hai-Fang Li · Jing Zhao · Wenbo Cao · Wenpeng Zhang · Yu Xia · Zheng Ouyang sn‐1 Specificity of Lysophosphatidylcholine Acyltransferase‐1 Revealed by a Mass Spectrometry‐based Assay 2022. Angewandte Chemie International Edition. Xue Zhao · Jiaqi Liang · Ziye Chen · Ruijun Jian · Yao Qian · Yunfang Wang · Zhiying Guo · Wenpeng Zhang · Ying Zhang · Hang Yin · Yu Xia Structural basis of leukotriene B4 receptor 1 activation 2022. Nature Communications. Na Wang · Xinheng He · Jing Zhao · Hualiang Jiang · Xi Cheng · Yu Xia · H. Eric Xu · Yuanzheng He A Liquid Chromatography-Mass Spectrometry Workflow for In-Depth Quantitation of Fatty Acid Double Bond Location Isomers 2021. Journal of Lipid Research. Jing Zhao · Mengxuan Fang · Yu Xia An Activatable Host–Guest Conjugate as a Nanocarrier for Effective Drug Release through Self-Inclusion 2021. ACS Applied Materials & Interfaces. Han Wu · Hua Wang · Feilong Qi · Tian Xia · Yu Xia · Jiang-Fei Xu · Xi Zhang Characterization of Fatty Acyl Modifications in Phosphatidylcholines and Lysophosphatidylcholines via Radical-Directed Dissociation 2021. Journal of the American Society for Mass Spectrometry. Xue Zhao · Yu Xia Deep Profiling of Aminophospholipids Reveals a Dysregulated Desaturation Pattern in Breast Cancer Cell Lines 2021. Analytical Chemistry. Qiaohong Lin · Pengyun Li · Mengxuan Fang · Donghui Zhang · Yu Xia Deep Structural Annotation of Glycerolipids by the Charge-Tagging Paterno–Büchi Reaction and Supercritical Fluid Chromatography–Ion Mobility Mass Spectrometry 2021. Analytical Chemistry. Tian Xia · Ming Yuan · Yongwei Xu · Feng Zhou · Kate Yu · Yu Xia Enabling High Structural Specificity to Lipidomics by Coupling Photochemical Derivatization with Tandem Mass Spectrometry 2021. Accounts of Chemical Research. Xiaoxiao Ma · Wenpeng Zhang · Zishuai Li · Yu Xia · Zheng Ouyang Mapping Complex Disulfide Bonds via Implementing Photochemical Reduction Online with Liquid Chromatography–Mass Spectrometry 2021. Journal of the American Society for Mass Spectrometry. Xiaoyue Yang · Yu Xia Mapping the Distribution of Double Bond Location Isomers in Lipids across Mouse Tissues 2021. The Analyst. Hanlin Ren · Alexander Triebl · Markus Wenk · Yu Xia · Federico Torta Photochemical Disulfide–Ene Modification Enhances Protein Sequencing and Disulfide Mapping by Mass Spectrometry 2021. Analytical Chemistry. Xiaoyue Yang · Longfei Zhang · Yu Xia Single-cell lipidomics with high structural specificity by mass spectrometry 2021. Nature Communications. Zishuai Li · Simin Cheng · Qiaohong Lin · Wenbo Cao · Jing Yang · Minmin Zhang · Aijun Shen · Wenpeng Zhang · Yu Xia · Xiaoxiao Ma · Zheng Ouyang Analysis of ether glycerophosphocholines at the level of C=C locations from human plasma 2020. The Analyst. Qiaohong Lin · Donghui Zhang · Yu Xia CHAPTER 7. Unsaturated Lipid Analysis via Coupling the Paternò–Büchi Reaction with ESI-MS/MS 2020 New Developments in Mass Spectrometry. Xiaoxiao Ma · Yu Xia Comprehensive Characterization of Phospholipid Isomers in Human Platelets 2020. Journal of Analysis and Testing. Wenpeng Zhang · Bing Shang · Yu Xia Coupling Headgroup and Alkene Specific Solution Modifications with Gas-Phase Ion/Ion Reactions for Sensitive Glycerophospholipid Identification and Characterization 2020. Journal of the American Society for Mass Spectrometry. Elissia Franklin · Samuel Shields · Jeffrey Manthorpe · Jeffrey C. Smith · Yu Xia · Scott A. Mcluckey Editorial- McLuckey special issue 2020 International Journal of Mass Spectrometry. Sharon J.pitteri · Yu Xia Enhanced Phospholipid Isomer Analysis by Online Photochemical Derivatization and RPLC-MS 2020. Analytical Chemistry. Wenpeng Zhang · Bing Shang · Zheng Ouyang · Yu Xia Large-scale lipid analysis with C=C location and sn-position isomer resolving power 2020. Nature Communications. Wenbo Cao · Simin Cheng · Jing Yang · Wenpeng Zhang · Zishuai Li · Qinhua Chen · Yu Xia · Zheng Ouyang · Xiaoxiao Ma Lipidome-Wide Characterization of Phosphatidylinositols and Phosphatidylglycerols on C=C Location Level 2020. Analytica Chimica Acta. Tian Xia · Hanlin Ren · Wenpeng Zhang · Yu Xia Next Generation Paternò-Büchi Reagents for Lipid Analysis by Mass Spectrometry 2020. Analytical Chemistry. Jing Zhao · Xiaobo Xie · Qiaohong Lin · Xiaoxiao Ma · Pei Su · Yu Xia Paternò-Büchi(PB)反应与串联质谱结合实现不饱和脂质精确结构解析 2020. 分析测试学报. Xiaoxiao Ma · Qingyuan Hu · Yu Xia Profiling of Cholesteryl Esters by Coupling Charge Tagging Paternò-Büchi Reaction and Liquid Chromatography-Mass Spectrometry 2020. Analytical Chemistry. Xiaobo Xie · Jing Zhao · Miao Lin · Jinlan Zhang · Yu Xia Resolving Modifications on Sphingoid Base and N-Acyl Chain of Sphingomyelin Lipids in Complex Lipid Extracts 2020. Analytical Chemistry. Xue Zhao · Gang Wu · Wenpeng Zhang · Mengqiu Dong · Yu Xia Structural elucidation of triacylglycerol using online acetone Paternò–Büchi reaction coupled with reversed-phase liquid chromatography mass spectrometry 2020. The Analyst. Elissia Tenea Franklin · Yu Xia Two-step reaction mechanism reveals new antioxidant capability of cysteine disulfides against hydroxyl radical attack 2020. Proceedings of the National Academy of Sciences. Sarju Adhikari · Ramon Crehuet · Josep M. Anglada · Joseph S. Francisco · Yu Xia Visible-Light Driven [2+2] Photocycloadditions between Benzophenone and C=C Bonds in Unsaturated Lipids 2020. Journal of the American Chemical Society. Haifang Li · Wenbo Cao · Xiaoxiao Ma · Xiaobo Xie · Yu Xia · Zheng Ouyang A lipidomic workflow capable of resolving sn- and C=C location isomers of phosphatidylcholines 2019. Chemical Science. Xue Zhao · Wenpeng Zhang · Donghui Zhang · Xinwei Liu · Wenbo Cao · Qinhua Chen · Zheng Ouyang · Yu Xia Analysis of Conjugated Fatty Acid Isomers by the Paternò-Büchi Reaction and Trapped Ion Mobility Mass Spectrometry 2019. Analytical Chemistry. Xiaobo Xie · Yu Xia A Polymer Coating Transfer Enrichment Method for Direct Mass Spectrometry Analysis of Lipids in Biofluid Samples 2019. Angewandte Chemie. Wenpeng Zhang · Spencer Chiang · Zishuai Li · Qinhua Chen · Yu Xia · Zheng Ouyang Coupling the Paternò-Büchi (PB) Reaction with Mass Spectrometry to Study Unsaturated Fatty Acids in Mouse Model of Multiple Sclerosis 2019. Frontiers in Chemistry. Leelyn Chong · Ran Tian · Riyi Shi · Zheng Ouyang · Yu Xia In-depth structural characterization of phospholipids by pairing solution photochemical reaction with charge inversion ion/ion chemistry 2019. Analytical and Bioanalytical Chemistry. Elissia T. Franklin · Stella K. Betancourt · Caitlin E. Randolph · Scott A. Mcluckey · Yu Xia Kaolin-based catalyst as a triglyceride FCC upgrading catalyst with high deoxygenation, mild cracking, and low dehydrogenation performances 2019. Catalysis Today. Hui Wang · Hongfei Lin · Ying Zheng · Siauw Ng · Hilary Brown · Yu Xia Mapping lipid C=C location isomers in organ tissues by coupling photochemical derivatization and rapid extractive mass spectrometry 2019. International Journal of Mass Spectrometry. Yuan Su · Xiaoxiao Ma · Jessica Page · Riyi Shi · Yu Xia · Zheng Ouyang Online photochemical derivatization enables comprehensive mass spectrometric analysis of unsaturated phospholipid isomers 2019. Nature Communications. Wenpeng Zhang · Donghui Zhang · Qinhua Chen · Junhan Wu · Zheng Ouyang · Yu Xia Top-down analysis of disulfide-linked proteins using photoinduced radical reactions and ET-DDC 2019. International Journal of Mass Spectrometry. Sarju Adhikari · Yu Xia · Scott A. Mcluckey Acetone/Isopropanol Photoinitiating System Enables Tunable Disulfide Reduction and Disulfide Mapping via Tandem Mass Spectrometry. 2018. Analytical Chemistry. Sarju Adhikari · Xiaoyue Yang · Yu Xia Determining Double Bond Position in Lipids Using Online Ozonolysis Coupled to Liquid Chromatography and Ion Mobility-Mass Spectrometry. 2018. Analytical Chemistry. Rachel A. Harris · Jody C. May · Craig A. Stinson · Yu Xia · John A. Mclean Expedient syntheses of N-heterocycles via intermolecular amphoteric diamination of allenes. 2018. Nature Communications. Zhishi Ye · Sarju Adhikari · Yu Xia · Mingji Dai Heptamolybdate: a highly active sulfide oxygenation catalyst. 2018. Dalton Transactions. Ashlin G. Porter · Hanfeng Hu · Xuemei Liu · Adharsh Raghavan · Sarju Adhikari · Derrick R. Hall · Dylan J. Thompson · Bin Liu · Yu Xia · Tong Ren Methods for analyzing a tissue sample 2018. Zheng Ouyang · Yu Xia · Xiaoxiao Ma Point-of-Care Tissue Analysis Using Miniature Mass Spectrometer. 2018. Analytical Chemistry. Ran Zou · Wenbo Cao · Leelyn Chong · Wei Hua · Hao Xu · Ying Mao · Jessica Page · Riyi Shi · Yu Xia · Tony Y. Hu · Wenpeng Zhang · Zheng Ouyang Rapid In Situ Profiling of Lipid C═C Location Isomers in Tissue Using Ambient Mass Spectrometry with Photochemical Reactions. 2018. Analytical Chemistry. Fei Tang · Chengan Guo · Xiaoxiao Ma · Jian Zhang · Yuan Su · Ran Tian · Riyi Shi · Yu Xia · Xiaohao Wang · Zheng Ouyang Reactivity of hydropersulfides toward the hydroxyl radical unraveled: disulfide bond cleavage, hydrogen atom transfer, and proton-coupled electron transfer. 2018. Physical Chemistry Chemical Physics. Josep M. Anglada · Ramon Crehuet · Sarju Adhikari · Joseph S. Francisco · Yu Xia Shotgun Analysis of Diacylglycerols Enabled by Thiol–ene Click Chemistry. 2018. Analytical Chemistry. Sarju Adhikari · Wenpeng Zhang · Xiaobo Xie · Qinhua Chen · Yu Xia