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个人简介

赵冬梅,女,1967年生,博士,教授,博士研究生导师。1989年7月毕业于沈阳药科大学,获化学制药专业理学学士学位,后分别于2000年和2007年获沈阳药科大学药物化学专业硕士和博士学位。2006年赴美国加州大学药学院旧金山分校作为高级访问学者进修一年。2008年被聘为沈阳药科大学教授兼博导,担任《中国药物化学杂志》编委。目前主要研究方向为心血管系统创新药物和抗肿瘤创新药物的研究与开发及专利过期药物合成工艺研究。作为课题负责人主持国家自然科学基金面上项目3项,作为项目子课题负责人负责国家自然科学基金重点项目1项、国家重大科技专项重大新药创制项目2项。辽宁省教育厅重点实验室基础研究项目1项、辽宁省教育厅优秀科技人才支持计划项目1项、辽宁省教育厅创新团队项目1项、辽宁省教育厅项目1项及沈阳市科技局项目4项等。有关研究内容发表论文100余篇,其中SCI收载57篇,出版著作4部。发明专利授权5项,受理6项,其中国际专利受理2项。目前已在J.Org.Chem.;Chem.Comm.;Eur.J.Med.Chem.;Org.Bio.Chem.;Bio.Org.Chem.;Bio.Org.Front.等SCI收载的杂志上发表论文57篇。

研究领域

流行病与卫生统计学研究方向一:基于靶点的心血管系统创新药物研究; 研究方向二:基于靶点的小分子抗肿瘤活性研究; 研究方向三:基于靶点的小分子抗深部真菌感染的活性研究

目前主要研究方向为心血管系统创新药物和抗肿瘤创新药物的研究与开发及专利过期药物合成工艺研究。

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

第一作者论文: 1.DongmeiZhao,ShizhenZhao,LiyuZhao,XiangqianZhang,PengWei,ChunchiLiu,ChenzhouHao,BinSun,XinSu,MaoshengCheng.Discoveryofbiphenylimidazolederivativesaspotentantifungalagents:Design,synthesis,andstructure-activityrelationshipstudies.[J]Bioorganic&medicinalchemistry.2017.25(2):750-758.(IF2.93) 2.DongmeiZhao,Hong-leiXie,Chang-linBai,Chun-chiLiu,Chen-zhouHao,Shi-zhenZhao,HongliYuan,ChangqunLuo,JianWang,BinLin,JiangZheng,Mao-ShengCheng.Design,synthesisandbiologicalevaluationofN,N-3-phenyl-3-benzylaminopropanamidederivativesasnovelCholesterylEsterTransferProteininhibitor.[J]Bioorganic&MedicinalChemistry.2016,24(8):1589-97.(IF2.79) 3.DongmeiZhao,BinSun,JinhongRen,FengrongLi,ShuaiSong,XuejiaoLv,ChenzhouHao,Mao-ShengCheng,SynthesisandBiologicalEvaluationof3-phenyl-2-(5-tert-butyl-2-methylFuran-3-carboxamido)propanoicacidDerivativesasSmallMoleculeInhibitorsofRetinoicAcid4-Hydroxylase(CYP26A1)[J]Bioorganic&MedicinalChemistry.2015,23:1356–1365.(IF2.79) 4.DongmeiZhao,Wen-YanLi,Yu-FangShi,Xu-QiongXiong,ShuaiSong,Chen-ZhouHao,Mao-ShengCheng,Jing-KangShen.Pharmacophore-baseddesign,synthesis,andbiologicalevaluationofnovel3-((3,4-dichlorophenyl)(4-substitutedbenzyl)amino)propanamiesascholesterylestertransferprotein(CETP)inhibitors.[J]ChineseChemicalLetters.2014,25:299–304.(IF1.58) 通讯作者论文: 1.ChenzhouHao,FanZhao,HongyanSong,JingGuo,XiaodongLi,XiaolinJiang,RanHuan‡,ShuaiSong,QiaolingZhang,RuifengWang,KaiWang,YuPang,TongchaoLiu,TianqiLu,WanxuHuang,JianWang,BinLin,ZhongguiHe,HaitaoLi,FengLi,,DongmeiZhaoandMaoshengCheng.Structure-BasedDesignof6‑Chloro-4-aminoquinazoline-2-carboxamideDerivativesasPotentandSelectivep21-ActivatedKinase4(PAK4)Inhibitors.[J]JournalofMedicinalChemistry.2018,61(1),265–285.(IF6.259); 2.JingGuo,FanZhao,WenboYin,MingyueZhu,ChenzhouHao,YuPang,TianxiaoWu,JianWang,DongmeiZhaoHaitaoLi,MaoshengCheng.Design,synthesis,structure-activityrelationshipsstudyandX-raycrystallographyof3-substituted-indolin-2-one-5-carboxamidederivativesasPAK4inhibitors.[J]EuropeanJournalofMedicinalChemistry2018,155,197-209.(IF4.81); 3.XiaolinJiang,JiahuiZhang,DongmeiZhaoandYuehuiLiAldehydeeffectandligand discoveryinRucatalyzeddehydrogenativecross-couplingofalcoholstoester.ChemComm.DOI: 10.1039/c8cc10315a.(IF6.8); 4.TongchaoLiu,ZhengdanZhu,HuanmingRen,YabinChen,GuohuaChen,MaoshengCheng,DongmeiZhao,JingkangShen,WeiliangZhu,BingXiongYue-LeiChen.Efficientsynthesesofalpha-andbeta-C-nucleosidesandtheoriginofanomericselectivity.[J]OrganicChemistryFrontiers2018,5(12),1992-1999.(IF5.45) 5.ShizhenZhao,XiangqianZhang,PengWei,XinSu,LiyuZhao,MengyaWu,ChenzhouHao,ChunchiLiu,DongmeiZhao,MaoshengCheng.Design,synthesisandevaluationofaromaticheterocyclicderivativesaspotentantifungalagents.[J]EuropeanJournalofMedicinalChemistry.2017,(137)96-107.(IF4.81) 6.JingGuo,MingyueZhu,TianxiaoWu,ChenzhouHao,KaiWang,ZizhengYan,WanxuHuang, JianWang,DongmeiZhao,MaoshengCheng.Discoveryofindolin-2-onederivativesaspotentPAK4inhibitors:Structure-activityrelationshipanalysis,biologicalevaluationand moleculardockingstudy[J]Bioorganic&MedicinalChemistry.2017,(25)3500–3511(IF4.59) 7.ChenzhouHao,WanxuHuang,XiaodongLi,JingGuo,MengChen,ZizhengYan,KaiWang,XiaolinJiang,ShuaiSong,JianWang,DongmeiZhao,FengLi,MaoshengCheng.Developmentof2,4-diaminoquinazolinederivativesaspotentPAK4inhibitorsbythecorerefinementstrategy[J]EuropeanJournalofMedicinalChemistry.2017,131:1-13.(IF4.81) 8.ShizhenZhao,LiyuZhao,XiangqianZhang,ChunchiLiu,ChenzhouHao,HongleiXie,BinSun,DongmeiZhao,Maosheng Cheng.Design,synthesis,andstructure-activityrelationshipstudiesofbenzothiazolederivativesasantifungalagents.[J]EuropeanJournalofMedicinalChemistry2016,123,514-522.(IF4.52) 9.ChunchiLiu,ChangqunLuo,LijuanHao,QiongWu,HongleiXie,ShizhenZhao,ChenzhouHao,DongmeiZhao,MaoshengCheng.Design,synthesisandbiologicalevaluationofnovelcholesterylestertransferproteininhibitorsbearingacycloalkenescaffold.[J]EuropeanJournalofMedicinalChemistry2016,123,419-430.(IF4.52) 10.ChenzhouHao,XiaodongLi,ShuaiSong,BingyuGuo,JingGuo,JianZhang,QiaolingZhang,WanxuHuang,JianWang,BinLin,MaoshengCheng,FengLi,DongmeiZhao.Advancesinthe1-phenanthryl-tetrahydroisoquinolineseriesofPAK4inhibitors:potentagentsrestraintumorcellgrowthandinvasion[J]Organic&BiomolecularChemistry.2016,14:7676-769(IF3.39) 11.ShuaiSong,XiaodongLi,JingGuo,ChenzhouHao,YanFeng,BingyuGuo,TongchaoLiu,QiaolingZhang,ZhenZhang,RuijuanLi,JianWang,BinLin,FengLi,DongmeiZhao,MaoshengCheng.Design,synthesisandbiologicalevaluationof1-phenanthryl-tetrahydroisoquinolinederivativesasnovelp21-activatedkinase4(PAK4)inhibitors.[J]Organic&BiomolecularChemistry2015,13(12):3803-3818.(IF3.56)

学术兼职

1.《中国药物化学杂志》编委; 2.《化学通报》和《中国药学杂志》审稿专家; 4、EuropeanJournalofMedicinalChemistry特约审稿人; 5、Bioorganic&MedicinalChemistryLetters特约审稿人; 6、JournalofChemicalInformationandModeling特约审稿人。

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