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个人简介

教育经历 2001.9-2006.7 中科院化学所 化学专业 硕博连读 1997.9-2001.7 南昌大学化学系 应用化学专业 学士 工作经历 2017.4-至今 天津医科大学药学院 副院长 2013.7-至今 天津医科大学药学院 教授,博士生导师 2010.11-2013.7 美国俄亥俄州州立大学心肺研究所 研究科学家 2006.10-2010.10 美国俄亥俄州州立大学心肺研究所 博士后

研究领域

稳定(双)自由基的研发及其磁共振应用 氧化还原探针研发及其生物医学应用 活性氧的可控产生及靶向传输 新型抗氧化剂研发及其作用机制

近期论文

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Weixiang Zhai, Yalan Feng, Huiqiang Liu, Antal Rockenbauer*, Deni Mance, Shaoyong Li, Yuguang Song*, Marc Baldus, Yangping Liu*, Diastereoisomers of L-Proline-linked TAM-nitroxide biradicals: synthesis and effect of chiral configurations on exchange interactions, Chem. Sci.2018, 9, 4381–4391. (IF 8.668, OutsideFrontCover) Xiaoli Tan, Shanqing Tao, Wenbo Liu, Antal Rockenbauer,Frederick A. Villamena,Jay L. Zweier, Yuguang Song,*Yangping Liu,*Synthesis and Characterization of Perthiatriarylmethyl Radical and Its Dendritic Derivatives with High Sensitivity and Selectivity to Superoxide Radical, Chem. Eur. J.2018, 24, 6958 – 6967.(IF 5.317, Front Cover) Jingli Hou, Meng Qian, Huanhuan Zhao, Yingchun Li, Yongfang Liao, Guifang Han, Zhelong Xu, Feng Wang, Yuguang Song,*Yangping Liu*, A Near-Infrared Ratiometric/Turn-on Fluorescent Probe for In Vivo Imaging of Hydrogen Peroxide in a Murine Model of Acute Inflammation, Anal. Chim. Acta2018, 1024, 169-176. (IF 4.95) Huan Liu, Xue Qu,* Eunkyoung Kim, Miao Lei, Kai Dai, Xiaoli Tan, Miao Xu, Jinyang Li, Yangping Liu, Xiaowen Shi, Peng Li, Gregory F. Payne, Changsheng Liu,* Bio-inspired redox-cycling antimicrobial film for sustained generation of reactive oxygen species, Biomaterials2018, 162, 109-122. (IF 8.402) Frederic Mentink-Vigier, Guinevere Mathies, Yangping Liu, Anne-Laure Barra, Marc A. Caporini, Daniel Lee, Sabine Hediger, Robert G. Griffin, Gael De Paepe,* Efficient cross-effect dynamic nuclear polarization without depolarization in high-resolution MAS NMR, Chem. Sci.2017, 8, 8150-8163. (IF 8.668) Xiaoli Tan, Li Chen, Yuguang Song, Antal Rockenbauer, Frederick A. Villamena, Jay L. Zweier,*Yangping Liu, *Thiol-dependent reduction of the triester and triamide derivatives of Finland trityl radical triggers O2-dependent superoxide production, Chem. Res. Toxicol. 2017, 30, 1664–1672. (IF 3.278) Wenbo Liu, Jiangping Nie, Xiaoli Tan, Huiqiang Liu, Nannan Yu, Guifang Han, Yutian Zhu, Frederick A. Villamena, Yuguang Song, Jay L. Zweier*and Yangping Liu,* Synthesis and Characterization of PEGylated Trityl Radicals: Effect of PEGylation on Physicochemical Properties, J. Org. Chem., 2017, 82, 588–596. (IF 4.849) Xiulan Li,§ Jingli Hou,§ Chao Peng, Li Chen, Wenbo Liu, Yangping Liu,* A 1,8-naphthalimide-based fluorescent probe for selective and sensitive detection of peroxynitrite and its applications in living cell imaging, RSC Adv. 2017, 7, 34287-34292. (IF 3.108) Xiaoli Tan, Yuguang Song,* Huiqiang Liu, Qinwen Zhong,* Antal Rockenbauer, Frederick A. Villamena, Jay L. Zweier and Yangping Liu*, Supramolecular host–guest interaction of trityl-nitroxide biradicals with cyclodextrins: modulation of spin–spin interaction and redox sensitivity, Org. Biomol. Chem., 2016, 14, 1694-701. (IF 3.564) Guinevere Mathies*, Marc A. Caporin, Vladimir K. Michaelis, Yangping Liu*, Kan-Nian Hu, Deni Mance, Jay L. Zweier, Melanie Rosay, Marc Baldus and Robert G. Griffin*, Efficient Dynamic Nuclear Polarization at 800 MHz/527 GHz with Trityl-Nitroxide Biradicals, Angew. Chem. Int. Ed., 2015, 54, 11770-4. (IF 11.994) Saipeng Huang, Rongcheng Han, Qianfen Zhuang, Libo Du*, Hongying Jia,Yangping Liu, Yang Liu*, New photostable naphthalimide-based fluorescent probe for mitochondrial imaging and tracking, Biosens. Bioelectron., 2015, 71, 313–321. (IF 7.78) Saipeng Huang, Zhao Chen, Libo Du, Qiu Tian, Yangping Liu*, Yuansuo Zheng*, Yang Liu*, Site-Specific Detection of Free Radicals in Membranes Using an Amphiphilic Spin Trap,Appl. Magn. Reson.2015, 46, 489-504. (IF 0.864) Yuguang Song, Yangping Liu,* Wenbo Liu, Frederick A. Villamena, Jay L. Zweier*, Characterization of the binding of the Finland trityl radical with bovine serum albumin, RSC Adv.2014, 4, 47649-47656. (IF 3.108) Libo Du,Saipeng Huang,Qianfen Zhuang, Hongying Jia,Antal Rockenbauer,Yangping Liu,*KeJian Liu* and Yang Liu*,Highly sensitive free radical detection by nitrone-functionalized gold nanoparticles, Nanoscale, 2014, 6, 1646-1652. (IF 7.367) David Johnson, Rizwan Ahmad, Yangping Liu, Alexandre Samouilov and Jay L. Zweier, Uniform Spinning Sampling Gradient Electron Paramagnetic Resonance Imaging,Magn. Reson. Med., 2014, 71, 893-900. (IF3.924) Yangping Liu, Frederick A. Villamena, Antal Rockenbauer,*Yuguang Song and Jay L. Zweier,*Structural factors controlling the spin-spin exchange coupling: EPR spectroscopic studies of strongly asymmetric trityl-nitroxide biradicals,J. Am. Chem. Soc., 2013, 135, 2350–2356. (IF 13.858) Yuguang, Song, Yangping Liu,* Craig Hemann, Frederick A. Villamena and Jay L. Zweier,* Esterified dendritic TAM radicals with very high stability and enhanced oxygen sensitivity, J. Org. Chem., 2013, 78, 1371–1376. (IF 4.849) Yangping Liu,§ Yuguang Song,§FrancescoDePascali, XiaopingLiu, Frederick A. Villamena and Jay L. Zweier,*Tetrathiatriarylmethyl radical with single aromatic hydrogen as a highly sensitive and specific superoxide probe, Free Radical Biol. Med., 2012, 54, 2081-2091.(IF 5.606) Zhongyu Yang, Yangping Liu, Peter Borbat, Jay L. Zweier,* Jack H. Freed,* Wayne L. Hubbell,* Pulsed ESR Dipolar Spectroscopy for Distance Measurements in Immobilized Spin Labeled Proteins in Liquid Solution, J. Am. Chem. Soc., 2012, 134, 9950–9952. (IF 13.858) Yangping Liu,Yuguang Song,Li-Bo Du, Frederick A. Villamena, Yiqiong Ji, Qiu Tian,Ke-Jian Liu, and Yang Liu,*Novel Glutathione-linked Nitrones as Dual Free Radical Probes, New J. Chem., 2011, 35, 1485-1490. (IF 3.269)

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