叶德举 - 南京大学 - 化学化工学院

个人简介

2015-Present: Professor, Nanjing University 2014-2015, Associate Professor, Nanjing University 2009-2014, Postdoc, School of Medicine, Stanford University 2004-2009: Ph.D., Shanghai Institute of Meteria Medica, Chinese Academy of Sciences 2000-2004: BS, School of Chemistry & Chemical Engineering, Nanjing University Brief biography Dr. Ye received B. S. in Chemistry from Nanjing University in 2004. Received Ph.D. in Drug Design and Medicinal Chemistry with Prof. Hualiang Jiang and Prof. Hong Liu from SIMM (CAS) in 2009, with dissertation of “Drug Design, Synthesis and Pharmacological Research of Privileged Structures”. Post-doctoral training in Prof. Jianghong Rao lab in Molecular Imaging Program at Stanford University (MIPS) from 2009 to 2014, where he developed multimodality molecular imaging probes for non-invasive detection of protease activity in vivo . He moved back to China and joined in Nanjing University as an associated professor in Oct 2014, and then promoted to full professor in Jun 2015. Research interests focus on the development of activatable multimodality molecular imaging probes for non-invasive detection of biomolecules both in cells and in living animals. Published more than 70 SCI papers, including Nat. Chem., JACS., Angew. Chem. Int. Ed., Chem. Soc. Rev., and Anal. Chem. Applied 7 patents. His work has been highlighted as ACS Editor Choice, highlighted lecture, highly cited paper, and so on. He has won honors and awards including IAAM Scientist Medal (2016), Young investigator travel award (2013) and Excellent graduate student of CAS (2009).

研究领域

Research in Ye Lab is aiming to integrate analytical chemistry, organic chemistry and nanotechnology to build activatable multimodality molecular imaging probes for real-time and non-invasive detection of biologically relevant molecules both in cells and in living animals. Guided by the imaging, we are aiming to provide approach for better diagnosis and treatment of diseases (e.g, cancers, Inflammation).

近期论文

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Ruibing An, Xiaoyang Cheng, Shixuan Wei, Yuxuan Hu, Yidan Sun, Zheng Huang, Hong-Yuan Chen, Deju Ye*. Angew. Chem. Int. Ed. 2020, DOI: 10.1002/anie.202009141. Yuxuan Hu#, Yuqi Wang#, Xidan Wen, Yifan Pan, Xiaoyang Chen, Ruibing An, Guandao Gao, Hong-Yuan Chen, Deju Ye*. Responsive Trimodal Probes for in Vivo Imaging of Liver Inflammation by Co-assembly and GSH-driven Disassembly. Research 2020, Accept. Rui Zhang#, Ruibing An#, Zhanni Gu, Haifeng Sun, Deju Ye*, Hong Liu*. Dehydroberberine Analogue Nanoassemblies for Inducing and Self-Reporting Mitochondrial Dysfunction in Tumor Cells. ACS Appl. Bio Mater.2020, DOI: 10.1021/acsabm.0c00747 (Invited). Yidan Sun, Hua Shi, Xiaoyang Cheng, Luyan Wu, Yuqi Wang, Zhengyang Zhou, Jian He, Hong-Yuan Chen, Deju Ye*. Degradable hybrid CuS nanoparticles for imaging-guided synergistic cancer therapy via low-power NIR-II light excitation. CCS Chem. 2020, 2, 1336-1349. https://doi.org/10.31635/ccschem.020.202000266. Chan Yang, Guosheng Song, Haifeng Yuan, Yue Yang, Yuqi Wang, Deju Ye, Hongmin Meng, Shuangyan Huan & Xiao-Bing Zhang*. Manganese–Fluorouracil Metallodrug Nanotheranostic for MRI-Correlated Drug Release and Enhanced Chemoradiotherapy. CCS Chem. 2020, 2, 1116-1128. https://doi.org/10.31635/ccschem.020.202000188. Yuqi Wang, Jianhui Weng, Xidan Wen, Yuxuan Hu, Deju Ye*. Recent advances in stimuli-responsive in situ self-assembly of small molecule probes for in vivo imaging of enzymatic activity. Biomater. Sci. 2020, https://doi.org/10.1039/D0BM00895H. Luyan Wu†, Wenhui Zeng†, Liandong Feng, Yuxuan Hu, Yidan Sun, Yingxiao Yan, Hong-Yuan Chen & Deju Ye*. An activatable ratiometric near-infrared fluorescent probe for hydrogen sulfide imaging in vivo. Sci. China Chem.2020, 63. 741-750. (SPECIAL ISSUE: Celebrating the 100th Anniversary of Chemical Sciences in Nanjing University) Yusuke Ishigaki, Takashi Harimoto, Keisuke Sugimoto, Luyan Wu, Wenhui Zeng, Deju Ye & Takanori Suzuki. Hexaarylbutadiene: a versatile scaffold with tunable redox properties towards organic near‐infrared electrochromic material. Chem. Asia J., 2020, doi.org/10.1002/asia.201901816. Yuqi Wang, Jianhui Weng, Jianguo Lin, Deju Ye & Yan Zhang*. NIR Scaffold Bearing Three Handles for Biocompatible Sequential Click Installation of Multiple Functional Arms. J. Am. Chem. Soc., 2020, 142, 6, 2787-2794. Luyan Wu, Yusuke Ishigaki, Yuxuan Hu, Keisuke Sugimoto, Wenhui Zeng, Takashi Harimoto, Yidan Sun, Jian He, Takanori Suzuki*, Xiqun Jiang, Hong-Yuan Chen & Deju Ye*. H2S-activatable near-infrared afterglow luminescent probes for sensitive molecular imaging in vivo.Nat. Commun. 2020, 11, 446. Yayun Peng, Chao Ye, Runqi Yan, Yuzhu Lei, Deju Ye, Hao Hong, Ting Cai*. Activatable Core–Shell Metallofullerene: An Efficient Nanoplatform for Bimodal Sensing of Glutathione. ACS Appl. Mater. Interfaces 2019, 11, 46637-46644. Available from https://doi.org/10.1021/acsami.9b18807 Ruibing An, Shixuan Wei, Zheng Huang, Fei Liu, Deju Ye*. An Activatable Chemiluminescent Probe for Sensitive Detection of γ-Glutamyl Transpeptidase Activity in Vivo. Anal. Chem. 2019, 91, 13639-13646. doi.org/10.1021/acs.analchem.9b02839. Muhammad Rizwan Younis, Ruibing An, Yun-Chao Yin, Shouju Wang, Deju Ye, Xing-Hua Xia*. Plasmonic Nanohybrid with High Photothermal Conversion Efficiency for Simultaneously Effective Antibacterial/Anticancer Photothermal Therapy. ACS Appl. Bio Mater. 2019, 2, 93942-3953. Available from https://doi.org/10.1021/acsabm.9b00521 Xiaoming Hu, Yufu Tang, Yuxuan Hu, Feng Lu, Xiaomei Lu, Yuqi Wang, Jie Li, Yuanyuan Li, Yu Ji, Wenjun Wang, Deju Ye, Quli Fan, Wei Huang. Gadolinium-Chelated Conjugated Polymer-Based Nanotheranostics for Photoacoustic/Magnetic Resonance/NIR-II Fluorescence Imaging-Guided Cancer Photothermal Therapy. Theranostics 2019, 9, 4168-4181. Available from http://www.thno.org/v09p4168.htm Runqi Yan, Yuxuan Hu, Fei Liu, Shixuan Wei, Daqing Fang, Adam J. Shuhendler, Hong Liu, Hong-Yuan Chen and Deju Ye* . Activatable NIR Fluorescence/MRI Bimodal Probes for in Vivo Imaging by Enzyme-Mediated Fluorogenic Reaction and Self-Assembly. J. Am. Chem. Soc.2019. 141, 10331-10341. Tie-Ying Xue,†,∥ Li-Ping Mei,†,∥ Yi-Tong Xu,† Yi-Li Liu,† Gao-Chao Fan,‡ Heng-Ye Li,*,§ Deju Ye,*,†and Wei-Wei Zhao*,† Nanoporous Semiconductor Electrode Captures the Quantum Dots: Toward Ultrasensitive Signal-On Liposomal Photoelectrochemical Immunoassay. Anal. Chem. 2019, 91, 3795-3799. Hua Shi, Yidan Sun, Runqi Yan, Shunli Liu, Li Zhu, Song Liu, Yuzhang Feng, Peng Wang, Jian He*, Zhengyang Zhou*, and Deju Ye*. Magnetic Semiconductor Gd-Doping CuS Nanoparticles as Activatable Nanoprobes for Bimodal Imaging and Targeted Photothermal Therapy of Gastric Tumors. Nano Lett. 2019, 19, 937–947. uhammad Rizwan Younis, Chen Wang, Ruibing An, Shouju Wang, Muhammad Adnan Youni, Zhong-Qiu Li, Yang Wang, Ayesha Ihsan, Deju Ye, and Xing-Hua Xia*. Low Power Single Laser Activated Synergistic Cancer Phototherapy Using Photosensitizer Functionalized Dual Plasmonic Photothermal Nanoagents. ACS Nano, 2019, DOI: 10.1021/acsnano.8b09552. uqi Wang, Xiaoming Hu, Jianhui Weng, Jinbo Li, Quli Fan, Yan Zhang, and Deju Ye*. A Photoacoustic Probe for the Imaging of Tumor Apoptosis by Caspase-Mediated Macrocyclization and Self-Assembly. Angew. Chem. Int. Ed. 2019, 58, 4886 . (VIP)