个人简介
教育经历
1978-1982 华中科技大学生物力学学士
1982-1984 华中科技大学生物医学工程硕士
1986-1990 哈佛大学生理学博士,
1991-1993 哈佛大学博士后
工作经历
1994-2005 哈佛大学助理教授、 副教授
2006至今 美国伊利诺伊大学香滨分校终身正教授, 细胞与分子力学实验室负责人
学术兼职
Cellular and Molecular Bioengineering副主编
Molecular Cell Biomechanics编委
被美国NIH任命为ICI委员会委员, 受邀为美国NIH, NASA, NSF等项目审核专家,也是我国教育部长江学者评审专家。
研究领域
长期从事细胞生物力学及再生医学机制研究,在细胞信号传导、细胞骨架调控机理及干细胞等领域开展了多项开拓性研究,取得了多项创新成果。主要研究领域:
1.力学信号对细胞结构稳定性及基因表达的影响;
2.力学信号对胚胎干细胞分化及发育的影响;
3.力学微环境对肿瘤干细胞及其转移的影响。
近期论文
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Seong J , Tajik A , Sun J , Guan JL , Humphries MJ , Craig SE , Shekaran A , García AJ , Lu S , Lin MZ , Wang N* , Wang Y*,"Distinct biophysical mechanisms of focal adhesion kinase mechanoactivation by different extracellular matrix proteins, "Proc Natl Acad Sci U S A 2013 Nov;110 (48): 19372-7. * Corresponding Author.
Liu J., T. T. Youhua, Z. H. Huafeng, Y. Zhang, P. Xu, C. J. Junwei, Y. C. Poh, K. Tang, N. Wang*, B. Huang*, "Soft Fibrin Gels Promote Selection and Growth of Tumorigenic Cells," Nature Materials. 11(8):734-41, 2012. PMID:22751180. PMC3405191.
Poh, Y. C., S. P. Shevtsov, F. Chowdhury, D. C. Wu, S. Na, M. Dundr*, and N. Wang*, "Dynamic Force-induced Direct Dissociation of Protein Complexes in a Nuclear Body in Living Cells," Nature Commun. 3: 866 doi:10.1038/ncomms1873. 2012. PMID: 22643893.
le Duc, Q., Q. Shi, I. Blonk, A. Sonnenberg, N. Wang*, D. Leckband*, and J. de Rooij*, "Vinculin Potentiates E-cadherin Mechanosensing and is Recruited to Actin-anchored Sites within Adherens Junctions in a MyosinII Dependent Manner," J Cell Biol., 189:1107-1115, June 28, 2010.
Chowdhury F, Na S, Li D, Poh YC, Tanaka T, Wang F, and Wang N*. "Material Properties of the Cell Dictate Stress-induced Spreading and Differentiation in Embryonic Stem Cells," Nat. Materials, Jan; 9(1):82-8, 2010. Publication online 18 October, 2009. DOI: 10.1038/NMAT2563. PMID: 19838182 PMC2833279