Wang, Peng - Georgia State University - Department of Chemistry

个人简介

Education B.S. (1984): Nankai University, China Ph.D (1990) : University of California, Berkeley Postdoc (1991-1992): University of California at Berkeley Postdoc (1992-1994): Scripps Research Institute Specializations Organic synthesis; peptide & glycopeptide synthesis; conjugation chemistry for sugar-protein & sugar-drug synthesis; protein cloning, expression & purification; glycoanalysis; proteomics.

近期论文

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Shukkoor M. Kondengaden, Huajie Zhang, Aishwarya Parameswaran, Liuqing Wen, Shrikant Pawar, Jing Song, Peng George Wang “DNA Encoded Glycan Library: A Universal Platform for Multiplex Analyses of Glycan Binding Proteins” 2018, Nature Method, submitted and under review Zhang, Jiabin ; Chen, Congcong; Gadi, Madhusudhan Reddy ; Gibbons, Christopher ; Cao, Xuefeng; Guo, Yuxi; Edmunds, Garrett ; Wang, Shuaishuai; Liu, Ding; Yu, Jin; Wen, Liuqing; Wang, Peng George “Machine Driven Enzymatic Oligosaccharide Synthesis”, 2018, Angewandte Chemie International Edition, accepted & in press. Wang, J., Greenway, H., Li, S., Wei, M., Polizzi, S. J., & Wang, P. G.. “Facile and Stereo-Selective Synthesis of UDP-α-D-xylose and UDP-β-L-arabinose Using UDP-Sugar Pyrophosphorylase”. 2018, Frontiers in chemistry, May, Volume 6, Article 163. Wang, N.; Yang, B.; Fu, C.; Zhu, H.; Zheng, F.; Kobayashi, T.;Liu, J.; Li,S.; Ma, C.; Wang, P. G.; Wang, Q.;Wang, L,; “Genetically Encoding Fluorosulphate-L-Tyrosine to React with Lysine, Histidine and Tyrosine via SuFEx in proteins in vivo” 2018, Journal of American Chemical Society 140(15), 4995-4999. Wang, S.; Zhang, Q.; Chen, C.; Guo, Y.; Gadi, M.R.; Yu, J.; Westerlind, U.; Liu,Y.; Cao, X.; Wang, P. G.; Li, L.; “Facile Chemoenzymatic Synthesis of O- mannosyl glycans” 2018, Angewandte Chemie International Edition 57(30), 9268-9273. Wen, L.; Gadi, M. R.; Zheng, Y.; Gibbons, C.; Kondengaden, S.; Zhang, J.; Wang, P. G. “Chemoenzymatic Synthesis of Unnatural Nucleotide Sugars for Enzymatic Biorthogonal Labeling” ACS Catalysis 2018, 8, 7659-7666. Yu, B.; Li, S.; Wang, J.; Zheng, Y.; Zhang, H.; Walker, M.-J.; Yuan, Z.; Zhu, H.; Zhang, J.; Wang, P. G.; Wang, B. “Biomarker-based Metabolic Labeling for Redirected and Enhanced Immune Response” ACS Chemical Biology 2018, 13(6), 1686-1694. Li, J.; Li, S.; Li, Q.; Long, J.; Ma, C.; Guo, J.; Ding, Y.; Yan, C.; Li, L .;Wu, Z; Zhu, H.; Li, K.-K.; Wen, L; Zhang, Q.; Ivanov, I.; Luo, M.; Xi, R.; Long, H.; Wang, P. G.; Chen, Y. “Natural Product Micheliolide (MCL) Irreversibly Activates PKM2 and Suppresses Leukemia” Journal of Medicinal Chemistry 2018, 61, 4155−4164. Wen, L.; Edmunds, G.; Gibbons, C.; Zhang, J.-B.; Gadi, M. R.; Zhu, H.-L.; Fang, J.-Q.; Liu, X.-W.; Kong, Y.; Wang, P. G. “Toward Automated Enzymatic Synthesis of Glycans” Chemical Review, 2018, accepted and in press. Purohit, S.; Li, T. -H.; Guan, W. -Y.; Song, X. -Z.; Song, J.; Tian, Y.’ Li, L.; Sharma, A.; Dun, B. -Y.; Mysona, D.; Ghamande, S.’ Rungruang, B.; Cummings, R. D.; Wang, P. G.; She, J. -X. “Multiplex glycan bead array for high throughput and high content analyses of glycan binding proteins” Nature Communications 2018, 9, 258. Zhang, Q.; Ma, C.; Gearing, M.; Wang, P. G.; Chin, L.-S.; Li, L. “Integrated proteomics and network analysis identifies protein hubs and network alterations in Alzheimer’s disease” Acta Neuropathological Communications 2018, 6:19. Wen, L.; Liu, D.; Zheng, Y.; Huang, K.; Cao, X.; Song, J.; Wang, P. G. “A one-step chemoenzymatic labeling Strategy for probing sialylated Thomsen-Friedenreich Antigen” ACS Central Science 2018, 4(4), 451-457. Wen, F.; Li, L.; Zhao, N.; Chiang, M. J.; Xie, H.; Cooley, J.; Webby, R.; Wang, P. G.; Wan, X. F. “AY161F Hemagglutinin Substitution Increases Thermostability and Improves Yields of 2009 H1N1 Influenza A Virus in Cells”. Journal of Virology 2018, Jan 2;92(2). Yang, B., Tang, S., Ma, C., Li, S.T., Shao, G.C., Dang, B., DeGrado, W.F., Dong, M.Q., Wang, P.G., Ding, S. and Wang, L. “Spontaneous and specific chemical cross-linking in live cells to capture and identify protein interactions.” Nature Communications 2017, 2240. Li, S., Wang, S., Fu, X., Liu, X.W., Wang, P. G. and Fang, J. “Sequential one-pot multienzyme synthesis of hyaluronan and its derivative.” Carbohydrate Polymers 2017, 221-227. Aguilar, A. L., Hou, X., Wen, L., Wang, P. G. and Wu, P. “A Chemoenzymatic Histology Method for O- GlcNAc Detection.” ChemBioChem 2017, 2416-2421. Zang, L., Kondengaden, S.M., Zhang, Q., Li, X., Sigalapalli, D.K., Kondengadan, S.M., Huang, K., Li, K.K., Li, S., Xiao, Z. and Wen, L., Wang, P.G. “Structure based design, synthesis and activity studies of small hybrid molecules as HDAC and G9a dual inhibitors.” Oncotarget 2017, 63187. Gashash, E.A., Aloor, A., Li, D., Zhu, H., Xu, X.Q., Xiao, C., Zhang, J., Parameswaran, A., Song, J., Ma, C. and Xiao, W. and Wang, P. G. “An Insight into Glyco-Microheterogeneity of Plasma von Willebrand Factor by Mass Spectrometry.” Journal of Proteome Research 2017, 3348-3362. Zhou, J., Liu, Y., Zhu, H., Zhu, H. and Wang, P. G. “Synthesis of silodosin glucuronide and its deuterated counterpart: solving a problematic O-glycosylation of a nitrogen-containing molecule.” Heterocyclic Communications 2017, 187-195.