李春梅 - 西南大学

个人简介

2022.06-至今：西南大学药学院，教授 2016/06-2022.06：西南大学药学院，副教授 2014/03-2016/05：西南大学，生物学博士后流动站，师资博士后 2011/09-2013/03：美国University of Florida（佛罗里达大学）化学系、生物/纳米交叉研究中心，纳米生物分析，联合培养博士 2009/09-2013/12：西南大学，分析化学，博士 2007/09-2009/06：西南大学，药物分析学，硕士（直博） 2003/09-2007/06：西南大学，应用化学，学士

研究领域

化学生物传感、药物分析、肿瘤成像与治疗。主要开展多功能荧光纳米探针的构建及其在疾病标志物检测、癌细胞成像分析、药物递送、肿瘤靶向治疗等方面的研究工作。

近期论文

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Zhang, Z.; Jin, J.; Paluzzi, V. E.; Jin, Z.; Wen, Y.D.; Huang, C. Z.; Li, C. M.*; Mao, C. D.*; Zuo, H.*, AMP aptamer programs DNA tile cohesion without canonical base pairing. J. Am. Chem. Soc. 2023, doi.org/10.1021/jacs.3c06260. Cheng, F.; Jiang, Y. J.; Kong, B.; Lin, H. R.; Shuai, X. J.; Hu, P.P.; Gao, P.F.; Zhan, L.; Huang, C. Z.; Li, C. M.* Multi-catcher polymers regulate the nucleolin cluster on the cell surface for cancer therapy. Adv. Healthc. Mater. 2023, DOI: 10.1002/adhm.202300102. Shuai, X.J.; Zhang, Y.; Zhai, J.; Li, J.; Chen, J.; Long, X.Y.; Li, D.; Huang, C. Z.; Li, C. M.* MicroRNA imaging encounters rolling circle amplification: intracellular Na+-fueled linear programmable DNAzyme nanostructure. Anal. Chem. 2023, 95, 6681-6689. Zhang, Y.; Cheng, F.; Liang. R., Shuai, X.J.; Nie, K. H.; Li, J.; Li, D.; Huang, C.Z.; Li, C. M.* In Situ activation of receptor aggregation by AI-Au intelligent nanomachine via tumor extracellular acidity to induce cell apoptosis. ACS Applied Materials & Interfaces. 2023, 15, 32262-32271. Li, L. L.; Lv, W. Y.; Xu, Y. T.; Li, Y. F.; Li, C. M.*; Huang, C. Z., DNA logic nanodevices for the sequential imaging of cancer markers through localized catalytic hairpin assembly reaction. Anal. Chem. 2022, 94, 4399-4406. Wang, N.; Jiang, Y. J.; Nie, K. H.; Li, D.; Liu, H.; Wang, J.; Huang, C. Z.; Li, C. M.*, Toehold-mediated strand displacement reaction-propelled cascade DNAzyme amplifier for microRNA let-7a detection. Chinese Chem. Lett. 2022, 107906. Li, L. L.; Cheng, F.; Li, J.; Zhen, S. J.; Lv, W. Y.; Shuai, X. J.; Li, Y. F.; Huang, C. Z.*; Li, C. M.*, Simultaneous response of mitochondrial microRNAs to identify cell apoptosis with multiple responsive intelligent DNA biocomputing nanodevices. Anal. Chem. 2023. 95, 29, 10992–10998. (IF 7.4) Liang, L.; Shuai, X. J.; Cao, L. P.; Wang, J.; Wang, Y.; Li, L.; Li, Y. F.; Huang, C. Z.*; Li, C. M.*, Endogenous adenosine triphosphate-assisted three-dimensional DNA walker assembled on soft nanoparticles for intracellular microRNA imaging. Anal. Chem. 2023, 95, 10721-10727. (IF 7.4) Liang, L.; Jiang, Y. J.; Zhang, L. C.; Liu, H.; Li, Y. F.; Li, C. M.*; Huang, C. Z.*, Rational fabrication of a DNA walking nanomachine on graphene oxide surface for fluorescent bioassay. Biosens Bioelectron, 2022, 211, 114349. Zheng, L. L.#; Shuai, X. J. #; Liu, Y.; Li, C. M.*; Zhen, S. J.; Liu, J. J.; Li, Y. F.; Huang, C. Z.*, One-donor-two-acceptors coupled energy transfer nanoprobe for recording of viral gene replication in living cells. Chem Eng J, 2022, 434, 134658. Wang, Y.; Bai, Y.; Cao, L. P.; Li, L. L.; Zhan, L.; Zuo, H.; Li, C. M.*; Huang, C. Z., Catalytic hairpin assembled polymeric tetrahedral DNA frameworks for MicroRNA imaging in live cells. Biosens Bioelectron. 2022, 197, 113783. Chai, S. Q.; Lv, W. Y.; He, J. H.; Li, Y. F.; Zou, H. Y.; Li, C. M.*; Huang, C. Z.*, Highly sensitive detection of miR-21 through target-activated catalytic hairpin assembly of X-Shaped DNA nanostructures. Anal. Chem. 2021, 93 (43), 14545-14551. Li, L. L.; Lv, W. Y.; Wang, Y.; Li, Y. F.; Li, C. M.*; Huang, C. Z.*, DNA logic nanodevices for real-time monitoring of ATP in lysosomes. Anal. Chem. 2021, 93 (46), 15331-15339. Wang, J. R.; Xia, C.; Yang, L.; Li, Y. F.; Li, C. M.*; Huang, C. Z.*, DNA nanofirecrackers assembled through hybridization chain reaction for ultrasensitive SERS immunoassay of prostate specific antigen. Anal. Chem. 2020, 92 (5), 4046-4052. Jiang, Y. J.; Wang, N.; Cheng, F.; Lin, H. R.; Zhen, S. J.; Li, Y. F.; Li, C. M.*; Huang, C. Z.*, Dual energy transfer-based DNA/graphene oxide nanocomplex probe for highly robust and accurate monitoring of apoptosis-related microRNAs. Anal. Chem. 2020, 92 (17), 11565-11572. Cheng, Y. Y.; Xie, Y. F.; Li, C. M.*; Li, Y. F.; Huang, C. Z.*, Förster resonance energy transfer-based soft nanoballs for specific and amplified detection of microRNAs. Anal. Chem. 2019, 91 (17), 11023-11029. Chai, S. Q.; Lv, W. Y.; He, J. H.; Li, C. H.; Li, Y. F.; Li, C. M.*; Huang, C. Z.*, Dual energy transfer-based fluorescent nanoprobe for imaging miR-21 in nonalcoholic fatty liver cells with low background. Anal. Chem. 2019, 91 (10), 6761-6768. Cheng, Y. Y.; Li, C. M.*; Mu, R. Z.; Li, Y. F.; Xing, T. T.; Chen, B. B.; Huang, C. Z.*, Dynamically long-term imaging of cellular RNA by fluorescent carbon dots with surface isoquinoline moieties and amines. Anal. Chem. 2018, 90 (19), 11358-11365. Yang, T.; Li, C. M.*; He, J. H.; Chen, B.; Li, Y. F.; Huang, C. Z.*, Ratiometrically fluorescent dlectrospun nanofibrous film as a Cu2+-mediated solid-phase immunoassay platform for biomarkers. Anal. Chem. 2018, 90 (16), 9966-9974. Chen, B. B.; Liu, M. L.; Zhan, L.; Li, C. M.*; Huang, C. Z.*, Terbium(III) modified fluorescent carbon dots for highly selective and sensitive ratiometry of stringent. Anal. Chem. 2018, 90 (6), 4003-4009.