田瑞军 - 南方科技大学

个人简介

田瑞军博士，南方科技大学化学系副教授（研究员），博士生导师（香港大学-南方科技大学联合博士培养项目等），加拿大渥太华大学医学院及深圳市人民医院兼职教授，中国蛋白质组组织CNHUPO常务理事、中国色谱协会理事、中国生物质谱协会理事和中国分子系统生物学学会理事，科技部“国家重点研发计划”蛋白质机器专项子课题负责人。 2008年在中国科学院大连化学物理研究所获得分析化学博士学位，师从邹汉法研究员，并获得中国科学院院长优秀奖和中国科学院优秀毕业生奖励。同年加入加拿大渥太华系统生物学研究所进行博士后研究，师从Daniel Figeys教授。2010年加入加拿大多伦多大学和西奈山医院继续博士后研究，师从Tony Pawson院士，并获得加拿大国立卫生研究院（CIHR）博士后基金资助。2014年起受聘南方科技大学化学系副教授（研究员）。致力于蛋白质组学的方法学和应用研究，在细胞信号转导、肿瘤微环境和干细胞定向分化等生物医学方向开展了卓有成效的应用研究。已在国际主流学术期刊上发表论文50余篇，其中以责任作者在Nature、PNAS、Mol. Cell. Proteomics、Anal. Chem.、Angew Chem.等上发表文章30余篇，作为客座主编发表专刊一部，SCI他1000余次，H-index为25 (Google Scholar)。曾荣获由国际蛋白质结构分析和蛋白质组学协会（IAPSAP）颁发的2012 Young Investigator Award，并在第八届世界蛋白质组学大会（HUPO）等做邀请或口头报告50余次。曾担任第五届中加系统生物学研讨会和第二届中国蛋白质组组织（CNHUPO）青年学者研讨会共同主席。担任国际期刊Frontiers in Endocrinology和Austin Proteomics的编委会委员职务。

研究领域

本研究组具有分析化学、化学生物学和生物化学等多学科交叉的研究优势，以重要基础生物学和转化医学问题为导向、细胞信号转导研究为切入点，开展蛋白质组学相关新方法和新技术研究，并强调在肿瘤微环境等生物医学方向的实际应用。主要研究方向包括： 1. 基于生物质谱的蛋白质组学新方法和新技术 2. 基于化学蛋白质组学技术的动态蛋白质复合物研究

近期论文

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Q.X. Cai, M.L. Zeng, X.D. Wu, H.W. Wu, Y.M. Zhan, R. J. Tian, M.J. Zhang, CaMKIIα-driven, phosphatase-checked postsynaptic plasticity via phase separation, Cell Research, Accepted. Y.H. Mao,‡ P.Z. Chen,‡ M. Ke, X. Chen, S.P. Ji, W.D. Chen, R. J. Tian,* Fully Integrated and Multiplexed Sample Preparation Technology for Sensitive Interactome Profiling, Anal. Chem., Accepted. Q. Wu, X.T. Sui, R. J. Tian,* Advances in High-throughput Proteomics Analysis, Chinese Journal of Chromatography, 2021, Accepted. M. Ke,‡ X. Yuan,‡ A. He, P.Y. Yu, W.D. Chen, Y. Shi, T. Hunter, P. Zou, R. J. Tian,* Spatiotemporal Profiling of Cytosolic Signaling Complexes in Living Cells by Selective Proximity Proteomics, Nature Communications, 2021, 12(1):71. J. N. Zheng,‡ X. Chen,‡ Y. Yang, C. S. H. Tan, R. J. Tian,* Mass Spectrometry-Based Protein Complex Profiling in Time and Space, Anal. Chem., 2021, 93, 598–619. J.N. Zheng, A. He, Y.H. Mao, L.J. Yang, C. S. H. Tan,* R. J. Tian,* Proteomics in Precision Medicine, Book Chapter of Detection Methods in Precision Medicine, Royal Society of Chemistry, Accepted. W. T. Li,‡ S. Z. Qiu,‡ J. Chen,‡ S. T. Jiang, W. D. Chen, J. W. Jiang, F. Wang, W. Si, Y. L. Shu, P. Wei, G. F. Fan, R. J. Tian, H. T. Wu,* C. Q. Xu,* H. P. Wang,* Chimeric Antigen Receptor Designed to Prevent Ubiquitination and Downregulation Showed Durable Antitumor Efficacy, Immunity, 2020, 53 Y. Yang, R. J. Tian,* Recent Progress in Capillary Electrophoresis-based High-sensitive Proteomics, Chinese Journal of Chromatography, 38 (2020) 1125 - 1132. W. N. Gao,‡ Q. Y, Zhang,‡ Y. R. Su, P. W. Huang, X, Lu, Q. Y. Gong, W. D. Chen, R. L. Xu, R. J. Tian,* Multiomic Analysis of Dried Single-Drop Plasma Sample by Integrated Mass Spectrometry Approach, Analyst, 2020, 145, 6441-6446. P. W. Huang,‡ C. Liu,‡ W. N. Gao, B. Z. Chu, Z. W. Cai, R. J. Tian,* Synergistic Optimization of LC and MS Parameters on Orbitrap Tribrid for High-efficient Data Dependent Proteomics, J. Mass Spectrum., Accepted. H. Li,‡ R. L. Xu,‡ L. J. Yang, H. M. Luan, S. L. Chen, L. Chen, Z. W. Cai,* R. J. Tian,* Combinatory Data Independent Acquisition and Parallel Reaction Monitoring Method for Deep Profiling of Gangliosides, Anal. Chem., 92, 2020, 10830-10838. P. W. Huang, Q. Kong, W. N. Gao, B. Z. Chu, H. Li, Y. H. Mao, Z. W. Cai, R. L. Xu, R. J. Tian,* Spatial Proteome Profiling by Immunohistochemistry-Based Laser Capture Microdissection and Data-Independent Acquisition Proteomics, Analytica Chimica Acta, 2020, 1127, 140-148. Q. Kong,‡ P. W. Huang,‡ B. Z. Chu, M. Ke, W. D. Chen, Z. D. Zheng, S. P. Ji, Z. W. Cai, P. F. Li, and R. J. Tian,* High-Throughput and Integrated Chemical Proteomic Approach for Profiling Phosphotyrosine Signaling Complexes, Anal. Chem., 2020, 92, 8933-8942. X. Lu,‡ Z. K. Wang,‡ Y. Gao, W. D. Chen, L. J. Wang, P. W. Huang, W. N. Gao, M. Ke, A. He, and R. J. Tian,* AutoProteome Chip System for Fully Automated and Integrated Proteomics Sample Preparation and Peptide Fractionation, Anal. Chem., 2020, 92, 8893-8900. Q. Zhang, Y. Zhang, H. Liu, H. Y. Chow, R. J. Tian, Y., M. E. Fung, X. C. Li,* OPA-Based Bifunctional Linker for Protein Labeling and Profiling, Biochemistry, 2020, 59, 2, 175-178. Y. Shi,* W. N. Gao, N. K. Lytle, P. W. Huang, X. Yuan, A. M. Dann, M. Ridinger, K. E. DelGiorno, G. Erikson, H. Y. Sun, J. Meisenhelder, E. Terenziani, P. Santisakultarm, U. Manor, R. L. Xu, M. Leblanc, S. E. Umetsu, E. A. Collisson, A. M. Lowy, T. Reya, T. R. Donahue, M. Downes, G. M. Wahl, R. M. Evans, T. Pawson, R. J. Tian,* T. Hunter,* Targeting LIF-Mediated Paracrine Interaction for Pancreatic Cancer Therapy and Monitoring, Nature, 2019, 569, 131-135. X. T. Ye,‡ J. Tang,‡ Y. H. Mao,‡ X. Lu, Y. Yang, W. D. Chen, X. Y. Zhang, R. L. Xu, R. J. Tian,* Integrated Proteomics Sample Preparation and Fractionation: Method Development and Applications, TrAC Trends Anal. Chem., 2019, 120, 115667. (Highlighted as Front Cover; Invited Review) Q. Y. Wu, N. Q. Lin, T. Tian, Z. Zhu, L. Wu, H. Y. Wang, D. L. Wang, D. Z. Kang,* R. J. Tian,* C. Y. Yang,* Evolution of Nucleic Acid Aptamers Capable of Specifically Targeting Glioma Stem Cells via Cell-SELEX, Anal. Chem., 2019, 91, 8070−8077. W. N. Gao,‡ H. J. Li,‡ L. P. Liu, P. W. Huang, Z. K. Wang, W. D. Chen, M. L. Ye, X. F. Yu, R. J. Tian,* An Integrated Strategy for High-sensitive and Multi-level Glycoproteome Analysis from Low Micrograms of Protein Samples, J. Chromatogr. A, 2019, 1600, 46-54. P. W. Huang, H. J. Li, W. N. Gao, Z. W. Cai,* R. J. Tian,* A Fully Integrated Spintip-Based Approach for Sensitive and Quantitative Profiling of Region-Resolved in Vivo Brain Glycoproteome, Anal. Chem., 2019, 91, 9181-9189.