Mezzenga, Raffaele - Eth Zürich - Laboratory of Food and Soft Materials

个人简介

Raffaele Mezzenga received his master degree (Summa Cum Laude) from University of Perugia, Italy, in Materials Science and Engineering, while actively working for the European Center for Nuclear Research (CERN), Geneva, and NASA, Houston, in problems related to the interaction between elementary particles and polymer-based structures (NASA Space Shuttle Discovery mission STS91). In 2001 he obtained a PhD in the field of Polymer Physics (with honors), from the Swiss Federal Institute of Technology, Lausanne (EPFL), focusing on the thermodynamics of thermoset-hyperbranched polymer reactive blends. He then spent 2001-2002 as a postdoctoral scientist at University of California, Santa Barbara, working on the self-assembly of polymer colloids for the design of new semiconductive organic materials. In 2003 he joined as research scientist the Nestlé Research Center (NRC), in Lausanne, working on the self-assembly of surfactants, natural amphiphiles and lyotropic liquid crystals. In 2005 he was hired as Associate Professor in the Physics Department of the University of Fribourg where he has been a board and founding member of the Fribourg Center for Nanomaterials (Frimat). He was appointed Full Professor at ETH Zurich on the fall 2009 to start a new group on Food and Soft Materials Science. Since 2010 he is also an Affiliated Professor of the Materials Department. His research focuses on the fundamental understanding of self-assembly processes in liquid crystalline polymers, supramolecular polymers, lyotropic liquid crystals, biological and food colloidal systems. Prof. Mezzenga has been a visiting Professor from Helsinki University of Technology and a Nestlé Distinguished Scientist. He is a board member of the Polymer and Colloid Division of the Swiss Chemical Society, winner of the 2004 Swiss National Science Foundation Professorship, recipient of the 2011 Young Scientist Research Award (PDF, 68 KB), the 2011 John H. Dillon Medal (American Physical Society) and the 2013 Biomacromolecules/Macromolecules Young investigator Award (American Chemical Society).

研究领域

We are interested in the understanding at a very fundamental level of the structure-properties relationship of complex food systems composed by biopolymers, proteins, biocolloids and surfactants, as well as in the study of their synthetic counterparts, which are used as model reference systems. We study the self-assembly and equilibrium properties of these materials at multiple length scales, in the dilute, semi-dilute and concentrated regime from a soft condensed matter physics perspective. To study the physics regulating the self-organization of these complex fluids, we rely on experimental techniques such as atomic force and transmission electron microscopy, static and dynamic light scattering, as well as small angle x-rays and neutron scattering. We also collaborate with theoretical groups worldwide in order to unravel the self-assembly processes via modern thermodynamic theories.

近期论文

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Rheology of Ultraswollen Bicontinuous Lipidic Cubic Phases Chiara Speziale, Reza Ghanbari and Raffaele Mezzenga Langmuir, 34 (17): 5052-5059, Washington, DC: American Chemical Society, 2018. Elasticity in Physically Cross-Linked Amyloid Fibril Networks Yiping Cao, Sreenath Bolisetty, Jozef Adamcik and Raffaele Mezzenga Physical Review Letters, 120 (15): 158103, College Park, MD: American Physical Society (APS), 2018. Polyphenol-Binding Amyloid Fibrils Self-Assemble into Reversible Hydrogels with Antibacterial Activity Bing Hu, Yang Shen, Jozef Adamcik, Peter Fischer, Mirjam Schneider, Martin J. Loessner and Raffaele Mezzenga ACS Nano, 12 (4): 3385-3396, Washington, DC: American Chemical Society, 2018. Biophotonics of Native Silk Fibrils Ulyana Shimanovich, Dorothea Pinotsi, Klimentiy Shimanovich, Na Yu, Sreenath Bolisetty, Jozef Adamcik, Raffaele Mezzenga, Jerome Charmet, Fritz Vollrath, Ehud Gazit, Christopher M. Dobson, Gabriele S. Kaminski Schierle, Chris Holland, Clemens F. Kaminski and Tuomas P.J. Knowles Macromolecular Bioscience, 18 (4): 1700295, Weinheim: Wiley-VCH, 2018. Curvature and bottlenecks control molecular transport in inverse bicontinuous cubic phases Salvatore Assenza and Raffaele Mezzenga Journal of Chemical Physics, 148 (5): 054902, Melville, NY: American Institute of Physics, 2018. Lipidic Mesophases as Novel Nanoreactor Scaffolds for Organocatalysts: Heterogeneously Catalyzed Asymmetric Aldol Reactions in Confined Water Michael Duss, Livia Salvati Manni, Laurent Moser, Stephan Handschin, Raffaele Mezzenga, Henning J. Jessen and Ehud M. Landau ACS applied materials & interfaces, 10 (5): 5114-5124, Washington, DC: American Chemical Society, 2018. Confinement-induced liquid crystalline transitions in amyloid fibril cholesteric tactoids Gustav Nyström, Mario Arcari and Raffaele Mezzenga Nature Nanotechnology, 13: 330-336, London: Nature Publishing Group, 2018. Design of ultra-swollen lipidic mesophases for the crystallization of membrane proteins with large extracellular domains Alexandru Zabara, Josephine T.Y. Chong, Isabelle Martiel, Laura Stark, Brett A. Cromer, Chiara Speziale, Calum J. Drummond and Raffaele Mezzenga Nature Communications, 9: 544, London: Nature Publishing Group, 2018. Correction: Competition between crystal and fibril formation in molecular mutations of amyloidogenic peptides (vol 8, 2017) Nicholas P. Reynolds, Jozef Adamcik, Joshua T. Berryman, Stephan Handschin, Ali Asghar Hakami Zanjani, Wen Li, Kun Liu, Afang Zhang and Raffaele Mezzenga Nature Communications, 8: 2284, London: Nature Publishing Group, 2017. Squid Suckerin Biomimetic Peptides Form Amyloid-like Crystals with Robust Mechanical Properties Shu H. Hiew, Antoni Sánchez-Ferrer, Shahrouz Amini, Feng Zhou, Jozef Adamcik, Paul Guerette, Haibin Su, Raffaele Mezzenga and Ali Miserez Biomacromolecules, 18 (12): 4240-4248, Washington, DC: American Chemical Society, 2017. Cofibrillization of Pathogenic and Functional Amyloid Proteins with Gold Nanoparticles against Amyloidogenesis Ibrahim Javed, Yunxiang Sun, Jozef Adamcik, Bo Wang, Aleksandr Kakinen, Emily H. Pilkington, Feng Ding, Raffaele Mezzenga, Thomas P. Davis and Pu C. Ke Biomacromolecules, 18 (12): 4316-4322, Washington, DC: American Chemical Society, 2017. Amyloid Fibrils form Hybrid Colloidal Gels and Aerogels with Dispersed CaCO3 Nanoparticles Yi Shen, Gustav Nyström and Raffaele Mezzenga Advanced Functional Materials, 27 (45): 1700897, Weinheim: Wiley-VCH, 2017. Copolyampholytes Produced from RAFT Polymerization of Protic Ionic Liquids Céline C. Fouillet, Tamar L. Greaves, John F. Quinn, Thomas P. Davis, Jozef Adamcik, Marc-Antoine Sani, Frances Separovic, Calum J. Drummond and Raffaele Mezzenga Macromolecules, 50 (22): 8965-8978, Washington, DC: American Chemical Society, 2017. Enzyme-Mimetic Antioxidant Luminescent Nanoparticles for Highly Sensitive Hydrogen Peroxide Biosensing Anna Pratsinis, Georgios A. Kelesidis, Stefanie Zuercher, Frank Krumeich, Sreenath Bolisetty, Raffaele Mezzenga, Jean-Christophe Leroux and Georgios A. Sotiriou ACS Nano, 11 (12): 12210-12218, Columbus, OH: American Chemical Society, 2017. Active Gating, Molecular Pumping, and Turnover Determination in Biomimetic Lipidic Cubic Mesophases with Reconstituted Membrane Proteins Chiara Speziale, Alexandru F. Zabara, Calum J. Drummond and Raffaele Mezzenga ACS Nano, 11 (11): 11687-11693, Columbus, OH: American Chemical Society, 2017. Absolute Quantification of Amyloid Propagons by Digital Microfluidics Manuela Pfammatter, Maria Andreasen, Georg Meisl, Christopher G. Taylor, Jozef Adamcik, Sreenath Bolisetty, Antoni Sánchez-Ferrer, David Klenerman, Christopher M. Dobson, Raffaele Mezzenga, Tuomas P.J. Knowles, Adriano Aguzzi and Simone Hornemann Analytical Chemistry, 89 (22): 12306-12313, Washington, DC: American Chemical Society, 2017. Implications of peptide assemblies in amyloid diseases Pu Chun Ke, Marc-Antonie Sani, Feng Ding, Aleksandr Kakinen, Ibrahim Javed, Frances Separovic, Thomas P. Davis and Raffaele Mezzenga Chemical Society Reviews, 46 (21): 6492-6531, Cambridge: Royal Society of Chemistry, 2017. Ice-Templated and Cross-Linked Amyloid Fibril Aerogel Scaffolds for Cell Growth Gustav Nyström, Wye-Khay Fong and Raffaele Mezzenga Biomacromolecules, 18 (9): 2858-2865, Washington, DC: American Chemical Society, 2017.