Wang, Yong - The Pennsylvania State University - Department of Biomedical Engineering

个人简介

EDUCATION 05/2004 Ph.D. in Biomedical Engineering Certificate in Biomolecular & Tissue Engineering Duke University, Durham, NC. Advisor: Prof. Fan Yuan. 06/1998 M.S. in Chemical Engineering Chinese Academy of Sciences, Dalian Institute of Chemical Physics,Dalian, China. Advisor: Prof. Xiaojun Ma. 06/1995 B.S. in Environmental Chemistry Jilin University, Changchun, China. WORKING EXPERIENCE 05/2020 – present Member, Center for Infectious Disease Dynamics, the Huck Institutes of the Life Sciences 07/2016 – present Professor of Biomedical Engineering 02/2015 – present Member, Molecular, Cellular and Integrative Biosciences Program, the Huck Institutes of the Life Sciences 01/2013 – 06/2016 Associate Professor of Biomedical Engineering University of Connecticut: 09/2011 - 12/2012 Associate Professor of Chemical and Biomolecular Engineering 12/2010 - 12/2012 Affiliated Faculty of Connecticut Institute for Clinical and Translational Science 01/2010 - 12/2012 Affiliated Faculty of Stem Cell Research Institute 05/2007 - 12/2012 Affiliated Faculty of Institute of Materials Science 01/2007 - 12/2012 Core Faculty of Biomedical Engineering 08/2006 - 08/2011 Assistant Professor of Chemical and Biomolecular Engineering Duke University: 12/2004 - 08/2006 Research Associate; Duke University Medical Center 06/2004 - 11/2004 Postdoctoral Fellow; Duke Biomedical Engineering

研究领域

Research Areas Protein Delivery for Regenerative Medicine Using Biomimetic Extracellular Matrix Our lab has pioneered the development of programmable tissue-like aptamer-functionalized hydrogels for on-demand protein drug release. Now we are using this emerging class of biomaterials for tissue engineering and regenerative medicine. We are also tuning these biomaterials for the treatment of cancer and diabetes. Cell Delivery Using Biomimetic Cell Wall & Extracellular Matrix We are developing new tools for cell surface engineering. In particular, we apply nucleic acids to synthesize programmable nanostructures to engineer the cell surface. Engineered cells will acquire more powerful functions than their natural counterparts and hold great potential for regenerative medicine, cancer treatment, drug delivery, etc. Engineered cells can also be tuned for ex vivo biomedical applications (e.g., tissue engineering and bioprinting). Protein & Cell Imaging Using Biomimetic Nanostructures Accurate and sensitive examination of proteins and cells is extremely important to understand biological mechanisms and diagnose the disease. However, it is challenging to do so since the amounts of proteins or cells are often very small. We are developing novel enzyme-free methods for signal amplification by using novel fluorescent nanostructures. These methods will be applied to cancer diagnosis and regenerative medicine.

近期论文

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L. Abune, B. Davis, Y. Wang *Aptamer-functionalized hydrogels: an emerging class of biomaterials for protein delivery, cell capture, regenerative medicine and molecular biosensing WIREs Nanomedicine and Nanobiotechnology. 2021; e1731 L. Abune, Y. Wang *Affinity hydrogels for protein delivery Trends in Pharmacological Sciences. 2021. 42 (4) 300-312 P. Shi, Y. Wang *Synthetic DNA for cell surface engineering Angewandte Chemie International Edition. 2021, 133 (21), 11684-11695 C. Li,$ M. Xu, $ J. Coyne,$ J. Yang, W.B. Wang, M. Devila, Y. Wang *, N. Xiong *CCL27/CCR10-derived regulatory signals suppress over-activation of IL-17A/IL-22-producing skin T cells and skin inflammation Journal of Allergy and Clinical Immunology. 2021. 147 (2), 759-763. e9 J. Zhou, Y. Wang *Cell recognition-inspired aptamer-based nanomaterials. In Y. Xie (Ed), The Nanobiotechnology Handbook. Novato: CRC Press. In press. N. Zhao, J. Coyne, L. Abune, P. Shi, X.L. Lian, G. Zhang, Y. Wang *Exogenous signaling molecules released from aptamer-functionalized hydrogels promote the survival of mesenchymal stem cell spheroids ACS Applied Materials & Interfaces. 2020, 12, 22, 24599-24610 Y. Wang, D. Kaplan Special issue: leaders in biomedical engineering. ACS Biomaterials Science & Engineering. 2020, 6 (5), 2495-2497 P. Shi, X. Wang, B. Davis, J. Coyne, C. Dong, Y. Wang *In situ In situ synthesis of an aptamer-based polyvalent antibody mimic on the cell surface for enhanced interactions between immune and cancer cells Angewandte Chemie International Edition. 2020, 59 (29), 11892-11897 J. Coyne, N. Zhao, A. Olubode, M. Menon, Y. Wang *Development of hydrogel-like biomaterials via nanoparticle assembly and solidhydrogel transformation.Journal of Controlled Release. 2020, 318, 185-196. H. Chen, S. Agrawal, A. Dangi, C. Wible, M. Osman, L. Abune, H. Jia, R. Rossi, Y.Wang, S. Kothapalli*Optical-resolution photoacoustic microscopy using transparent ultrasound transducer.Sensors. 2019, 19, 5470 O. Juhl IV, N. Zhao, A. Merife, D. Cohen, M. Friedman, Y. Zhang, Z. Schwartz, Y.Wang, H. Donahue*Aptamer-functionalized fibrin hydrogel improves vascular endothelial growth factor release kinetics and enhances angiogenesis and osteogenesis in critically sized cranial defects. ACS Biomaterials Science & Engineering. 2019, 5,11, 6152-6160 P. Shi, N. Zhao, J. Coyne, Y. Wang*DNA-templated synthesis of biomimetic cell wall for nanoencapsulation and protection of live cells.Nature Communications. 10: 2223 (2019) L. Abune, N. Zhao, J. Lai, B. Peterson, S. Szczesny, Y. Wang*.Macroporous hydrogels for stable sequestration and sustained release of VEGF and bFGF using nucleic acid aptamers.ACS Biomaterials Science & Engineering. 2019, 5(5), 2382-2390. N. Zhao, A. Suzuki, X. Zhang, P. Shi, L. Abune, J. Coyne, H. Jia, N. Xiong, G.Zhang, Y. Wang*.Dual Aptamer-functionalized In Situ Injectable Fibrin Hydrogel for Promotion of Angiogenesis via Co-delivery of VEGF and PDGF-BB ACS Applied Materials & Interfaces. 2019, 11, 20, 18123-18132 N. Zhao, J. Coyne, A. Suzuki, M. Xu, X. Zhang, P. Shi, J. Lai, N. Xiong, G.H., Fong,Y. Wang*Assembly of Bifunctional Aptamer-Fibrinogen Macromer for VEGF Delivery and Skin Wound Healing.Chemistry of Materials. 2019, 31(3), 1006-1015. J. Lai, N. Zhao, L. Abune, Y. Wang*Programmed degradation of hydrogels with a double-locked domain.Angewandte Chemie International Edition. 2019, 58, 2820-2825 Wang, Y.*Programmable Hydrogels (Invited review).Biomaterials. 2018,178, 663-680. Shi, P., Zhao, N., Lai, J., Coyne, J., Gaddes, E.R., Wang, Y.*Polyvalent display of biomolecules on live cells (Inside Cover).Angewandte Chemie International Edition. 2018, 57 (23), 6800-6804. Coyne, J., Davis, B., Kauffman, D., Zhao, D., Wang, Y.* Polymer microneedle mediated local aptamer delivery for blocking the function of VEGF ACS Biomaterials Science & Engineering. 2017, 3(12), 3395-3403. Lai, J., Li, S., Shi, X., Coyne, J., Zhao, N., Dong, F., Mao, Y., Wang, Y.* Displacement and hybridization reactions in aptamer-functionalized hydrogels for biomimetic protein release and signal transduction. Chemical Science. 2017, 8 (11), 7306-7311.