孙红哲 - 香港大学

个人简介

2018−present: Norman & Cecilia Yip Professor in Bioinorganic Chemistry 2018−present: Chair Professor 2007−2018: Professor 2004−2007: Associate Professor 1998−2004: Assistant Professor, Department of Chemistry, The University of Hong Kong 1996− 1998: GlaxoWellcome Research Fellow, Department of Chemistry, The University of Edinburgh, Great Britain 1993− 1996: Ph.D., The University of London (Birkbeck College) Great Britain 1990− 1993: Research Associate and Lecturer, Coordination Chemistry Institute, Nanjing University, P.R. China

研究领域

Our research interest lies in Biological Inorganic Chemistry, in particular, metal in biology and medicine including design, synthesis of metalloagents as antimicrobials (or resistance breakers), and antivirals. Our particular interest is on bismuth drugs from mechanistic study to medicinal application. To understand the mechanism of action of metalloagents, we have established metalloproteomic approaches e.g. GE-ICP-MS/LC-GE-ICP-MS, fluorescence based approach, together with proteomics, metabolomics and transcriptomics, providing a platform for understanding the role of metals in biology and medicine at a system level. We are also interested in the structure and function of metalloproteins, in particular those that may serve as potential targets of metallodrugs.

近期论文

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Zhou Y., Li H.Y., Sun H.Z.* "Metalloproteoics for biomedical research: methodology and applications". Annual Review of Biochemistry (Editor: Kornberg, R.), doi: 10.1146/annurev-biochem-040320-104628 Zhang Q.§, Wang R.M.§, Wang M.J., Liu C.J., Koohi-Moghadam M., Wang H.B., Ho P.L., Li H.Y., Sun H.Z.* "Re-sensitization of mcr carrying multidrug resistant bacteria to colistin by silver". Proceedings of the National Academy of Sciences USA, 119 (11) e2119417119, doi: 10.1073/pnas.2119417119 Li H.Y., Sun H.Z.* "A hydroxide lock for metallo-β-lactamases" . Nature Chemistry, 14, 6-8, doi: 10.1038/s41557-021-00871-3 Wang R.M.§, Chan J.F.W.§, Wang S.Y.§, Li H.Y., Zhao J.J., Ip T.K.Y., Zuo J.Z., Yuen K.Y., Yuan S.F., Sun H.Z.* "Orally administrated bismuth drug together with N-acetyl cysteine as a broad-spectrum anti-coronavirus cocktail therapy". Chemical Science, 13, 2238-2248, doi: 10.1039/D1SC04515F. Yan X.T., Zhou Y., Jiang G.B., Li H.Y., Sun H.Z.* "Metallomics and metalloproteomics", in Comprehensive Inorganic Chemistry III (Editor: Pecoraro, V.P., Guo, Z.J.), accepted Zhou Y., Tse E.W.C., Leung R., Cheung E., Li H.Y., Sun H.Z.* "Multiplex single-cell analysis of cancer cells enables unbiased uncovering subsets associated with cancer relapse: heterogeneity of multidrug resistance in precursor B-ALL", ChemMedChem, 16, doi: /10.1002/cmdc.202100638. Wang C., Li X., Cheng T.F., Sun H.Z., Jin L.J.* "Eradication of porphyromonas gingivalis persisters through colloidal bismuth subcitrate synergistically combined with metronidazole", Frontiers in Microbiology, 12, 748121, doi: 10.3389/fmicb.2021.748121. Li Y.F.*, Sun H.Z. "Metallomics in multidisciplinary research and the analytical advances", Atomic Spectroscopy, 42(5), 227-230, doi: 10.46770/AS.2021.108. Zhao J.T., Wang L.M., Cui L.W., Sun H.Z.*, Gao Y.X., Li Y.F.* "Metallomics for the screening of COVID-19 and metallodrug development", Atomic Spectrscopy, 42(5), 231-237, doi: 10.46770/AS.2021.805. Griffith D.§, Li H.Y.§, Werrett M.W., Andrews P., Sun H.Z.* "Medicinal chemistry and biomedical applications of bismuth-based compounds", Chemical Society Review, 50(21), 12037-12069, doi: 10.1039/D0CS00031K. Hu X.Q.§, Li H.Y.§, Ip T.K.Y., Cheung Y.F., Koohi-Moghadam M., Wang H.B., Yang X.M., Tritton D. N., Wang Y.C., Wang Y., Wang R.M., Ng K.M., Naranmandura H., Tse E.W.C., Sun H.Z.* "Arsenic trioxide targets Hsp60, triggering degradation of p53 and survivin". Chemical Science, 12(32), 10893-10900, doi: 10.1039/D1SC03119H Maimaitiyiming Y., Wang Q.Q., Yang C., Ogra Y., Lou Y.J., Smith C.A., Hussain L., Shao Y.M., Lin J.B., Liu J.F., Wang L.F., Zhu Y., Lou H.Y., Huang Y., Li X.X., Chang K.J., Chen H. Li H.Y., Huang, Y., Tse, E., Sun, J., Bu, N., Chiou, S.H., Zhang, E.F, Hua, H.Y., Ma, L.Y., Huang, P., Ge, M.H., Cao F.L., Cheng X.D., Sun H.Z., Zhou J., Vasliou V., Xu P., Jin J., Bjorklund M., Zhu H.H., Hsu C.H., Naranmandura H.* "Hyperthermia selectively destabilizes ongoneic fusion proteins". Blood Cancer Discovery, 2(4), 388-401, doi: 10.1158/2643-3230.BCD-20-0188. Wang H.B., Wang M.J., Xu X.H., Gao P., Xu Z.L., Zhang Q., Li H.Y., Yan A.X., Kao R.Y. -T., Sun H.Z.* “Multi-target mode of action of silver against Staphylococcus aureus endows it with capability to combat antibiotic resistance”. Nature Communications, 12, 3331, doi: 10.1038/s41467-021-23659-y. Yuan S.F., Yin X., Meng X.Z., Chan J.F.W., Ye Z.W., Riva L., Pache L., Chan C.C.Y., Lai P.M., Chan C.C.S., Poon V.K.M., Lee A. C.Y., Matsunaga N., Pu Y., Yuen C.K., Cao J.L., Liang R.H., Tang K.M., Sheng L., Du Y.S., Xu W., Lau C.Y., Sit K.Y., Au W.K., Wang R.M., Zhang Y.Y., Tang Y.D., Clausen T.M., Pihl J., Oh J., Sze K.H., Zhang A.J.X., Chu H., Kok K-H., Wang D., Cai X.H., Esko J.D., Hung I.F.N., Li R.A., Chen H.L., Sun H.Z., Jin D.Y., Sun R., Chanda S.K., Yuen K.Y.* (2021) “Clofazimine is a broad-spectrum coronavirus inhibitor that antagonizes SARS-CoV-2 replication in primary human cell culture and hamsters”. Nature, 593, 418-423. doi: 10.1038/s41586-021-03431-4. Xu X.H.§, Wang H.B.§, Li H.Y., Sun H.Z.* (2021) “Dynamic and temporal transcriptomic analysis reveals ferroptosis-mediated anti-leukemia activity of S-dimethylarsino-glutathione: insights into novel therapeutic strategy” CCS Chemistry, 3, 1089-1100. doi: 10.31635/ccschem.021.202000685. Tse E.C.M.*, Sun H.Z.* (2020) Book review for “Transition Metals and Sulfur –A Strong Relationship for Life”, Metal Ions in Life Sciences, vol. 20, Zeitschrift für Naturforschung C, 76(5-6)c, 257-259, doi: 10.1515/znc-2020-0252. Zhou Y., Ip T.K.Y., Zhang Q., Li H.Y., Sun H.Z.* (2020) “Metal complexes as drugs and chemotherapeutic agents” in Comprehensive Coordination Chemistry III (Volume 9: “Applications of Coordination Chemistry”), 680-705, Elsevier. doi: 10.1016/B978-0-08-102688-5.00018-0. Wang H.B.*, Yang X.M., Wang M.J., Xu X.H., Hu M.L, Yan A.X., Hao Q., Li H.Y., Sun H.Z.* (2020) “Atomic differentiation of silver binding preference in protein targets: Escherichia coli malate dehydrogenase as a paradigm” Chemical Science, 11(43), 11714-11719. doi: 10.1039/D0SC04151C. Yuan S.F.§, Wang R.M.§, Chan J.F.W.§, Zhang A.J., Cheng T.F., Chik K.K.H., Ye Z.W., Wang S.Y., Lee A.C., Jin L.J., Li H.Y., Jin D.Y., Yuen K.Y.*, Sun H.Z.* (2020) “Metallodrug ranitidine bismuth citrate suppress SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters” Nature Microbiology, 5(11), 1439-1448. doi: 10.1038/s41564-020-00802-x. Sun H.Z. §*, Zhang Q.§, Wang R.M.§*, Wang H.B., Wong Y.T., Wang M.J., Hao Q., Yan A.X., Kao R.Y.T., Ho P.L., Li H.Y. (2020) “Resensitizing carbapenem- and colistin-resistant bacteria to antibiotics using auranofin” Nature Communications, 11(1), 5263, doi: 10.1038/s41467-020-18939-y. Wang R.M., Wang S.Y., Chan S., Zuo Z., Chan G.C.F., Li H.Y., Sun H.Z.* (2020) “Bismuth porphyrin antagonizes cisplatin-induced nephrotoxicity via inactivating caspase-dependent apoptotic pathway” iScience, 23(5), 101054. doi: 10.1016/j.isci.2020.101054. Tao X., Zhang Z.M., Zhang X., Li H.Y., Sun H.Z.*, Mao Z.W., Xia W.* (2020) “Structural insight into the substrate gating mechanism by Staphylococcus aureus aldehyde dehydrogenase” CCS Chemistry, 2(3), 946-954. doi: 10.31635/ccschem.020.202000219. Xu X.H., Wang H.B., Li H.Y., Sun H.Z.* (2020) “Metalloproteomic approaches for matching metals to proteins: The power of inductively coupled plasma mass spectrometry (ICP-MS)” Chemistry Letter, 49(6), 697-704. doi: 10.1246/cl.200155. (invited, featured on the front cover) Kanatzidis M., Sun H.Z., Dehnen S.* (2020) “Bismuth- the magic element” Inorganic Chemistry, 2020, 59(6) 3341-3343. doi: 10.1021/acs.inorgchem.0c00222. (editorial) Wang H.B., Zhou Y., Xu X.H., Li H.Y., Sun H.Z.* (2020) “Metalloproteomics in conjunction with other omics for uncovering the mechanism of action of metallodrugs: mechanism-driven new therapy development” Current Opinion in Chemical Biology, 55, 171-179. doi: 10.1016/j.cbpa.2020.02.006. (invited) Wang R.M., Li H.Y., Ip T.K.Y., Sun H.Z.* (2020) “Chapter 6 − Bismuth drugs as antimicrobial agents” Advances in Inorganic Chemistry, 75, 183-205. doi: 10.1016/bs.adioch.2019.10.011. Jiang N., Wang Y.L., Chan K.C., Sun H.Z.*, Li G.J.* (2020) “Additive manufactured graphene coating with synergistic photothermal and superhydrophobic effects for bactericidal applications” Global Challenges, 4(1), 1900054. doi: 10.1002/gch2.201900054. Koohi-Moghadam M., Wang H.B., Wang Y.C., Yang, X.M., Li H.Y., Wang J.W.*, Sun H.Z.* (2019) “Predicting disease-associated mutation of metal binding sites of a protein using a deep learning approach” Nature Machine Intelligence, 1(12), 561-567. doi: 10.1038/s42256-019-0119-z. (Highlighted as a ‘news&views’ entitled “DEEP LEARNING IN MEDICINE Predicting cracks in metalloproteins”, 1(12), 553-554) Xu Z.L., Wang P.C., Wang H.B., Hang Z., Au-Yeung H.Y., Hirayama T. Sun H.Z., Yan A.X. (2019) “Zinc excess leads to an increased cellular demand for iron and decreased tolerance to copper in Escherichia coli” Journal of Biological Chemistry, 294(45), 16978-16991. doi: 10.1074/jbc.RA119.010023. Xu, X.H., Wang H.B., Li, H.Y., Hu X.Q., Zhang Y., Guan X.Y., Toy P.H., Sun H.Z.* (2019) “S-dimethylarsino-glutathione (darinaparsin®) targets Histone H3.3, leading to TRAIL-induced apoptosis in leukemia cells” Chemical Communications, 55(87), 13120-13123. doi: 10.1039/C9CC07605K. Jiang N., Li H., Sun H.Z.* (2019) “Recognition of proteins by metal chelation-based fluorescent probes in cells” Frontiers in Chemistry, 7, 560. doi: 10.3389/fchem.2019.00560 (invited) Wang Y.C., Li H.Y., Sun H.Z.* (2019) “Metalloproteomics for unveiling the mechanism of action of metallodrugs and their candidates” Inorganic Chemistry, 58(20), 13673-13685. doi: 10.1021/acs.inorgchem.9b01199. (featured in the Supplementary cover) Wang H.B., Wang M.J., Yang X.M., Xu X.H., Hu M.L., Yan A.X., Hao Q., Lobinski R., Li H.Y., Sun H.Z.* (2019) “Antimicrobial silver targets glyceraldehyde-3-phosphate dehydrogenase in E. coli”, Chemical Science, 10(30), 9193-7199. doi: 10.1039/C9SC02032B. Wang Y.C., Han B.J., Xie Y.X., Wang H.B., Wang R.M., Xia W., Li H.Y., Sun H.Z.* (2019) “Combination of gallium(III) with acetate for combating antibiotic resistant Pseudomonas aeruginosai”, Chemical Science, 10(24), 6099-6106. doi: 10.1039/C9SC01480B. (ChemSci Pick of the Week and HOT Article) Wang R.M., Li H.Y., Sun H.Z.* (2019) “Bismuth: environmental pollution and health effects” in Encyclopedia of Environmental Health, 2nd edition, edited by Nriagu J., Elsevier. 415-423. doi: 10.1016/B978-0-12-409548-9.11870-6. (invited contribution) Cheng T.F., Lai Y.T., Wang Y., Jiang N., Li H.Y., Sun H.Z.*, Jin L.J.* (2019) “Bismuth drugs tackle Porphyromonas gingivalis and attune cytokine response in human cells”, Metallomics, 11(7), 1207-1218. doi: 10.1039/c9mt00085b. Yang Y., Chang C.C., Lai Y.Z., Yang X.M., Sun H.Z.*, Li H.Y.* (2019) “Green fluorescent probe for imaging His6-tagged protein inside living cells” ACS Sensors, 4(5), 1190-1196. doi: 10.1021/acssensors.8b01128. Wang H.B., Yan A.X., Liu Z.G., Yang X.M., Xu Z.L., Wang M.J., Hu M.L., Wang Y.C., Wang R.M., Koohi-Moghadam M., Hu L.G., Xia W., Hao Q., Tang H.R., Wang Y.L., Li H.Y., Sun H.Z.* (2019) “Deciphering molecular mechanism of silver allows enhancing its antimicrobial efficacy”, PLOS Biology, 17(6): e3000292. doi: 10.1371/journal.pbio.3000292. Guo Y., Guan C.J., Wan H.Y., Zhang Z.G, Li H.Y., Sun H.Z., Xia W.* (2019) “Inactivation of NikR from Helicobacter pylori by a bismuth drug”, Journal of Inorganic Biochemistry, 196, 110685. doi: 10.1016/j.jinorgbio.2019.03.025. Zhang Z.M, Huang Q., Xu D., Tao X., Song G.B., Zheng P., Li H.Y., Sun H.Z., Xia W.* (2019) “The unique trimeric assembly of virulence factor HtrA from Helicobacter pylori via N-terminus domain-swapping”, Journal of Biological Chemistry, 294(20), 7990-8000. doi: 10.1074/jbc.RA119.007387. Chan S., Wang R.M., Man K., Nicholls J., Li H.Y., Sun H.Z.*, Chan G.C.* (2019) “A novel synthetic compound, bismuth zinc citrate, could potentially reduce cisplatin-induced toxicity without compromising the anticancer effect through enhanced expression of antioxidant protein” Translational Oncology, 2019, 12(5), 788-799. doi: 10.1016/j.tranon.2019.02.003. Koohi-Moghadam M., Borad M., Tran N., Swanson K, Boardman L., Sun H.Z.*, Wang J.W.* (2019) “MetaMarker: a de novo pipeline for discovering novel metagenomic biomarkers” Bioinformatics, 35(19), 3812-3814. doi: 10.1093/bioinformatics/btz123. Li H.Y., Wang R.M., Sun H.Z.* (2019) “Systems approaches for unveiling the mechanism of action of bismuth drugs: new medicinal applications beyond Helicobacter pylori infection” Accounts of Chemical Research, 52(1), 216-227. doi: 10.1021/acs.accounts.8b00439. Cheng Y.H., Cheung Y.F., Tam T.S.C., Lok C.N., Sun H.Z., Ng K.M.* (2019) “Plasmonic metal nanoparticles as efficient mass tags for ion signal amplification and ultrasensitive detection of protein markers” Analytical Chimica Acta, 1055, 1-6. doi: 10.1016/j.aca.2018.12.057. (selected as “featured article”) Yang X.L., Liu X., Wu Q.Q., Lv X., Li B., Sun H.Z., Xu W.F., Liao X.L.* (2019) "Dopamine-assisted immobilization of peptide arginine-glycine-aspartic acid to enhance the cellular performances of MC3T3-E1 cells of carbon-carbon composites", Journal of Biomaterials Applications, 34(2), 284-296. doi: 10.1177/0885328219845962. Yang L.M., Xing S.Y., Sun H.Z., Miao C.L., Li M., Lv P.M., Wang Z.M., Yuan Z.H.* (2019) "Citric-acid-induced mesoporous SAPO-11 loaded with highly dispersed nickel for enhanced hydroisomerization of oleic acid to iso-alkanes", Fuel Processing Technology, 187, 52-62. doi: 10.1016/j.fuproc.2019.01.008.