Bishai, William R. - Johns Hopkins University

个人简介

Co-Director, Center for Tuberculosis Research Dept. of Medicine, Div. of Infectious Diseases Johns Hopkins School of Medicine

研究领域

I am interested in the molecular pathogenesis of tuberculosis. Since Mycobacterium tuberculosis senses and adapts to a wide array of conditions during the disease process, it is clear that the regulation of expression of virulence factors plays an important role in pathogenesis. Hence a theme of my research has been to assess mycobacterial genes important in gene regulation. Other active interests are cell division in mycobacteria and the pathogenesis of caseation and cavitation. The use of the mouse and rabbit models of tuberculosis has been a prominent aspect of these studies. Goals of the research program are first to better understand tuberculosis pathogenesis, and then to employ this understanding towards improved drugs, vaccines, and diagnostics.

近期论文

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Nedeltchev, G. G., T. R. Raghunand, M. S. Jassal, S. Lun, Q. J. Cheng, and W.R. Bishai. 2009. Extrapulmonary dissemination of Mycobacterium bovis but not Mycobacterium tuberculosis in a bronchoscopic rabbit model of cavitary tuberculosis. Infect Immun 77:598-603. Jassal, M., and W.R. Bishai. 2009. Extensively drug-resistant tuberculosis. Lancet Infect Dis 9:19-30. Greenberg, J. D., G. Reed, J. M. Kremer, E. Tindall, A. Kavanaugh, C. Zheng, W. Bishai, and M. Hochberg. 2009. Association of Methotrexate and TNF antagonists with risk of infection outcomes including opportunistic infections in the CORRONA registry. Ann Rheum Dis. Converse, P. J., P. C. Karakousis, L. G. Klinkenberg, A. K. Kesavan, L. H. Ly, S. S. Allen, J. H. Grosset, S. K. Jain, G. Lamichhane, Y. C. Manabe, D. N. McMurray, E. L. Nuermberger, and W.R. Bishai. 2009. Role of the dosR-dosS two-component regulatory system in Mycobacterium tuberculosis virulence in three animal models. Infect Immun 77:1230-7. Conde, M. B., A. Efron, C. Loredo, G. R. De Souza, N. P. Graca, M. C. Cezar, M. Ram, M. A. Chaudhary, W.R. Bishai, A. L. Kritski, and R. E. Chaisson. 2009. Moxifloxacin versus ethambutol in the initial treatment of tuberculosis: a double-blind, randomised, controlled phase II trial. Lancet 373:1183-9. Be, N. A., K. S. Kim, W.R. Bishai, and S. K. Jain. 2009. Pathogenesis of central nervous system tuberculosis. Curr Mol Med 9:94-9. Alahari, A., L. Alibaud, X. Trivelli, R. Gupta, G. Lamichhane, R. C. Reynolds, W.R. Bishai, Y. Guerardel, and L. Kremer. 2009. Mycolic acid methyltransferase, MmaA4, is necessary for thiacetazone susceptibility in Mycobacterium tuberculosis. Mol Microbiol 71:1263-77. Manabe, Y. C., A. K. Kesavan, J. Lopez-Molina, C. L. Hatem, M. Brooks, R. Fujiwara, K. Hochstein, M. L. Pitt, J. Tufariello, J. Chan, D. N. McMurray, W.R. Bishai, A. M. Dannenberg, Jr., and S. Mendez. 2008. The aerosol rabbit model of TB latency, reactivation and immune reconstitution inflammatory syndrome. Tuberculosis (Edinb) 88:187-96. Lee, J. H., P. C. Karakousis, and W.R. Bishai. 2008. Roles of SigB and SigF in the Mycobacterium tuberculosis sigma factor network. J Bacteriol 190:699-707. Lee, J. H., D. E. Geiman, and W.R. Bishai. 2008. Role of stress response sigma factor SigG in Mycobacterium tuberculosis. J Bacteriol 190:1128-33. Klinkenberg, L. G., L. A. Sutherland, W.R. Bishai, and P. C. Karakousis. 2008. Metronidazole lacks activity against Mycobacterium tuberculosis in an in vivo hypoxic granuloma model of latency. J Infect Dis 198:275-83. Karakousis, P. C., E. P. Williams, and W.R. Bishai. 2008. Altered expression of isoniazid-regulated genes in drug-treated dormant Mycobacterium tuberculosis. J Antimicrob Chemother 61:323-31. Be, N. A., G. Lamichhane, J. Grosset, S. Tyagi, Q. J. Cheng, K. S. Kim, W.R. Bishai, and S. K. Jain. 2008. Murine model to study the invasion and survival of Mycobacterium tuberculosis in the central nervous system. J Infect Dis 198:1520-8. Abdul-Majid, K. B., L. H. Ly, P. J. Converse, D. E. Geiman, D. N. McMurray, and W.R. Bishai. 2008. Altered cellular infiltration and cytokine levels during early Mycobacterium tuberculosis sigC mutant infection are associated with late-stage disease attenuation and milder immunopathology in mice. BMC Microbiol 8:151. Williams, E. P., J. H. Lee, W.R. Bishai, C. Colantuoni, and P. C. Karakousis. 2007. Mycobacterium tuberculosis SigF regulates genes encoding cell wall-associated proteins and directly regulates the transcriptional regulatory gene phoY1. J Bacteriol 189:4234-42. Rosenthal, I. M., M. Zhang, K. N. Williams, C. A. Peloquin, S. Tyagi, A. A. Vernon, W.R. Bishai, R. E. Chaisson, J. H. Grosset, and E. L. Nuermberger. 2007. Daily dosing of rifapentine cures tuberculosis in three months or less in the murine model. PLoS Med 4:e344. Lun, S., and W.R. Bishai. 2007. Characterization of a novel cell wall-anchored protein with carboxylesterase activity required for virulence in Mycobacterium tuberculosis. J Biol Chem 282:18348-56. Lamichhane, G., and W. Bishai. 2007. Defining the 'survivasome' of Mycobacterium tuberculosis. Nat Med 13:280-2. Jain, S. K., S. M. Hernandez-Abanto, Q. J. Cheng, P. Singh, L. H. Ly, L. G. Klinkenberg, N. E. Morrison, P. J. Converse, E. Nuermberger, J. Grosset, D. N. McMurray, P. C. Karakousis, G. Lamichhane, and W.R. Bishai. 2007. Accelerated detection of Mycobacterium tuberculosis genes essential for bacterial survival in guinea pigs, compared with mice. J Infect Dis 195:1634-42. Almeida, D., E. Nuermberger, S. Tyagi, W.R. Bishai, and J. Grosset. 2007. In vivo validation of the mutant selection window hypothesis with moxifloxacin in a murine model of tuberculosis. Antimicrob Agents Chemother 51:4261-6.