研究领域

Analytical Chemistry/Inorganic Chemistry/Organic Chemistry/Physical Chemistry/Biological Chemistry/Chemical Education/Computational/Theoretical Chemistry/Environmental/Atmospheric Chemistry/Materials Chemistry and Nanoscience

Research in the Sharp laboratory focuses on the combination of biological chemistry and mass spectrometry to address problems in protein structural characterization, protein modification by oxidative stress, and detailed structural analysis of sulfated glycosaminoglycans.

近期论文

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R. Huang, Z.-J. Liu, J.S. Sharp. 2013. An approach for separation and complete structural sequencing of heparin/heparan sulfate-like oligosaccharides. Anal. Chem. 85: 5787-5795. PMID:23659663 X. Li, Z. Li, B. Xie, J.S. Sharp. 2013. Improved identification and relative quantification of sites of peptide and protein oxidation for hydroxyl radical footprinting . J. Am. Soc. Mass Spectrom. 24: 1767-1776. PMID:24014150 L.G. Kuhns, M. Mahawar, J.S. Sharp, S. Benoit, R.J. Maier. 2013. Role of Heliobacter pylori methionine sulfoxide reductase in urease maturation. Biochem. J. 450: 141-148. PMID:23181726 X Wang, JS Sharp, TM Handel, JH Prestegard. 2013. Chemokine oligomerization in cell signaling and migration. Prog. Mol. Biol. Transl. Sci. 117: 531-578. PMID:23663982 S.L. Benoit, K. Bayyareddy, M. Mahawar, J.S. Sharp, R.J. Maier. 2013. Heliobacter pylori peptide methionine sulfoxide reductase repairs critical methionine residues in alkyl hydroperoxide reductase . J. Bacteriol. In press.: -. V.H. Pomin, Y. Park, R. Huang, C. Heiss, H,H, Sharp, P. Azadi, J.H. Prestegard. 2012. Exploiting enzyme specificities in digestions of chondroitin sulfates A and C: production of well-defined hexasaccharides. Glycobiol. 22: 826-838. PMID:22345629 M. Mahawar, V. Tran, J.S. Sharp, R.J. Baier. 2011. Synergistic roles of Heliobacter pylori methionine sulfoxide reductase and GroEL in repairing oxidant damaged catalase. . J. Biol. Chem. 286: 19159-19169. PMID:21460217 V.H. Pomin, J.S. Sharp, X. Li, L. Wang, J.H. Prestegard. 2010. Characterization of glycosaminoglycans by 15N NMR spectroscopy and in vivo isotopic labeling. Anal. Chem. 82: 4078-4088. PMID:20423049 M. Bern, J. Saladino, J.S. Sharp. 2010. Conversion of methionine into homocysteic acid in heavily oxidized proteomics samples. Rapid Commun. Mass Spectrom. 24: 768-772. PMID:20169556 J. Saladino, M.T. Swulius, D. Live, J.S. Sharp. 2009. Alipahatic peptidyl hydroperoxides as a source of secondary oxidation in hydroxyl radical protein footprinting. J. Amer. Soc. Mass Spectrom. 20: 1123-1126. PMID:19278868 C. Watson, I. Janik, T. Zhuang, O. Charvatova, R.J. Woods, J.S. Sharp. 2009. Pulsed electron beam water radiolysis for submicrosecond hydroxyl radical protein footprinting. Anal. Chem. 81: 2496-2505. PMID:19265387 B.C. Gau, J.S. Sharp, D.L. Rempel, M.L. Gross. 2009. Fast photochemical oxidation of proteins footprints faster than protein unfolding. Anal. Chem. 81: 6563-6571. PMID:20337372 O. Charvatova, B.L. Foley, M. Bern, J. Sharp, R. Orlando, R.J. Woods. 2008. Quantifying protein interface footprinting by hydroxyl radical oxidation and molecular dynamics simulation: application to galectin-1. J. Am. Soc. Mass Spectrom. 19: 1692-1705. PMID:18707901 J.G. Smedley, J.S. Sharp, J.F. Kuhn, K.B. Tomer. 2008. Probing the pH-dependent prepore to pore transition of Bacillus anthracis protective antigen with differential oxidative protein footprinting. Biochemistry 47: 10694-10704. PMID:18785752