徐四龙 - 西安交通大学

个人简介

2020.1-今教授、博士生导师，西安交通大学理学院化学系 2015.8-2016.8 访问学者，加州大学-伯克利分校 2014.12-2019.12 副教授、西安交通大学理学院化学系 2012.6-2014.11 讲师，西安交通大学理学院化学系 2006.9-2012.7 硕士、博士，南开大学化学学院，元素有机化学国家重点实验室，有机化学专业 2004.9-2006.7 衡南一中，化学教师 2000.9-2004.7 本科，湖南师范大学化学化工学院，应用化学专业

研究领域

The Silong Research Group is interested in synthetic organic chemistry focusing on the development of new synthetic methodology and total synthesis of natural products and pharmaceuticals. Research Topics Phosphine-mediated transformations Lewis base catalysis for cyclopropane ring opening C-H activation via transition metal catalysis Total synthesis of complex bioactive natural product targets

近期论文

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Kaki, R. B.; Li, Y.; Xu, W.*; Tang, Y.; Zhang, W.*; Xu, S.*, Multicomponent Benzannulation of Allylic P-ylides with Isocyanates or Aldehydes for Construction of Anilines and Biaryls. Chem. Commun. 2020, doi: 10.1039/D0CC03461D. Kaki, R. B.; Han, W.; Chen, J.-B.; Li, Y.; Tang, Y.; Zhang, W.; Xu, W.*; Xu, S.*, Three-Component Reaction of Phosphorus Ylides with Isocyanates: Facile Synthesis of 2-Amino-3-Carboxylate-4-Quinolones. Chem. Commun. 2020, 56, 5909-5912. Kaki, R. B; He, X.; Xu, S.*, Lewis Base Catalysis Based on Homoconjugate Addition: Rearrangement of Electron-Deficient Cyclopropanes and Their Derivatives. Synlett 2020, 31 (02), 117-124. He, X.; Tang, Y.; Wang, Y.; Chen, J.-B.; Xu, S.*; Dou, J.; Li, Y.*, Phosphine-Catalyzed Activation of Alkylidenecyclopropanes: Rearrangement to Form Polysubstituted Furans and Dienones. Angew. Chem., Int. Ed. 2019, 58 (31), 10698-10702. Li, Y.*; Shi, D.; He, X.; Wang, Y.; Tang, Y.; Zhang, J.; Xu, S.*, Redox-Neutral Annulation of Alkynylcyclopropanes with N-aryloxyamides via Rhodium(III)-Catalyzed Sequential C−H/C−C Activation. J. Org. Chem. 2019, 84 (3), 1588-1595. Wei, W.; Tang, Y.; Zhou, Y.; Deng, G.; Liu, Z.; Wu, J.; Li, Y.; Zhang, J.; Xu, S.*, Recycling Catalyst as Reactant: A Sustainable Strategy To Improve Atom Efficiency of Organocatalytic Tandem Reactions. Org. Lett. 2018, 20 (20), 6559-6563. [PDF] Li, Y.*; Xu, S.*, Transition Metal-Catalyzed C−H Functionalization for Construction of Quaternary Carbon Centers. Chem. Eur. J. 2018, 24 (61), 16218-16245. [PDF] Li, Y.*; Shi, D.; Tang, Y.; He, X.; Xu, S.* Rhodium(III)-Catalyzed Redox-Neutral C−H Activation/Annulation of N-Aryloxyacetamides with Alkynyloxiranes: Synthesis of Highly Functionalized 2,3-Dihydrobenzofurans. J. Org. Chem. 2018, 83 (16), 9464-9470. [PDF] Wu, J.; Tang, Y.; Wei, W.; Wu, Y.; Li, Y.; Zhang, J.; Zheng, Y.; Xu, S.*, Phosphine-Catalyzed Activation of Vinylcyclopropanes: Rearrangement of Vinylcyclopropylketones to Cycloheptenones. Angew. Chem. Int. Ed. 2018, 57 (21), 6284-6288. [PDF] Wu, J.; Zhang, J.-Y.; Gao, P.; Xu, S.; Guo, L.-N., Copper-Catalyzed Redox-Neutral Cyanoalkylarylation of Activated Alkenes with Cyclobutanone Oxime Esters. J. Org. Chem. 2018, 83 (2), 1046-1055. [PDF] Zhang, J.; Tang, Y.; Wei, W.; Wu, Y.; Li, Y.; Zhang, J.; Zheng, Y.; Xu, S.*, An Organocatalytic Cloke−Wilson Rearrangement: DABCO-Catalyzed Ring Expansion of Cyclopropyl Ketones to 2,3-Dihydrofurans. Org. Lett. 2017, 19 (12), 3043-3046. [PDF] Li, Y.*; Tang, Y.; He, X.; Shi, D.; Wu, J.; Xu, S.*, Rhodium(III)-Catalyzed Annulative Carbooxygenation of 1,1-Disubstituted Alkenes Triggered by C−H Activation. Chem. Eur. J. 2017, 23 (31), 7453-7457. [PDF] Hu, X.; Xu, S.; Maimone, T. J., A Double Allylation Strategy for Gram-Scale Guaianolide Production: Total Synthesis of (+)-Mikanokryptin. Angew. Chem. Int. Ed. 2017, 56 (6), 1624-1628. [PDF] Xu, S.*; Chen, J.; Shang, J.; Qing Z.; Zhang, J.; Tang Y.*, Divergent Amine-Catalyzed [2+2] Annulation of Allenoates with Azodicarboxylates: Facile Synthesis of 1,2-Diazetidines. Tetrahedron Lett. 2015, 56(46), 6456–6459. [PDF] Chen, R.; Xu, S.*; Fan, X.; Li, H.; Tang, Y.; He, Z.*, Construction of Dispirocyclohexanes via Amine-Catalyzed [2 + 2 + 2] Annulations of Morita-Baylis-Hillman Acetates with Exocyclic Alkenes. Org. Biomol. Chem. 2015, 13 (2), 398-408. [PDF] Xu, S.*; Zhu, S.; Shang, J.; Zhang, J.; Tang, Y.; Dou, J.*, Catalyst-Free Synthesis of Skipped Dienes from Phosphorus Ylides, Allylic Carbonates, and Aldehydes via a One-Pot SN2' Allylation-Wittig Strategy. J. Org. Chem. 2014, 79 (8), 3696-3703. [PDF] Xu, S.; Wang, L.; Tang, Y.; He, Z., Ethoxide-Mediated Condensation of γ-tert-Butylallenoate and Aldehydes: Facile Stereoselective Synthesis of Conjugated Dienes and Enynes. Synthesis 2014, 46 (15), 2085-2092. [PDF] Xu, S.*; Tang, Y.*, Catalytic Approaches to Stoichiometric Phosphine-Mediated Organic Reactions. Lett. Org. Chem. 2014, 11(7), 524-533. [PDF] Xu, S.*; Shang, J.; Zhang, J.; Tang, Y.*, Regioselective SN2' Mitsunobu reaction of Morita–Baylis–Hillman alcohols: A facile and stereoselective synthesis of α-alkylidene-β-hydrazino acid derivatives. Beilstein J. Org. Chem. 2014, 10, 990-995. [PDF] Xu, S.; He, Z., Progress on Vinylogous Organic Reactions of Allylic Phosphorus Ylides with Carbonyl Compounds. Chin. J. Org. Chem. 2014, 34, 2438-2447. [PDF]