个人简介

California Institute of Technology, Ph.D., Chemistry, 1971 University of Minnesota, B.S., Chemistry, 1966

研究领域

Analytical Chemistry/Inorganic Chemistry/Organic Chemistry/Physical Chemistry/Biological Chemistry/Chemical Education/Computational/Theoretical Chemistry/Environmental/Atmospheric Chemistry/Materials Chemistry and Nanoscience

Research in the Prestegard laboratory focuses on nuclear magnetic resonance (NMR) methods development and application of those methods to challenging problems involving soluble proteins, membrane proteins, cell-surface carbohydrates, and carbohydrate-protein interactions. Many of these systems are drug targets and understanding the structural and functional consequences of interactions that mimic drug-biomolecule interactions is a key part of drug design.

近期论文

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Lee, H. W. ; Wylie, G. ; Bansal, S. ; Wang, X. ; Barb, A. W. ; Macnaughtan, M. A. ; Ertekin, A. ; Montelione, G. T. ; Prestegard, J. H. Three-dimensional structure of the weakly associated protein homodimer SeR13 using RDCs and paramagnetic surface mapping. Protein Science 2010, 19, 1673-1685. Jiang, Y. ; McKinnon, T. ; Varatharajan, J. ; Glushka, J. ; Prestegard, J. H. ; Sornborger, A. T. ; Schuttler, H. B. ; Bar-Peled, M. Time-Resolved NMR: Extracting the Topology of Complex Enzyme Networks. Biophysical Journal 2010, 99, 2318-2326. Pomin, V. H. ; Sharp, J. S. ; Li, X. Y. ; Wang, L. C. ; Prestegard, J. H. Characterization of Glycosaminoglycans by N-15 NMR Spectroscopy and in Vivo Isotopic Labeling. Analytical Chemistry 2010, 82, 4078-4088. Shapira, B. ; Prestegard, J. H. Electron-nuclear interactions as probes of domain motion in proteins. Journal of Chemical Physics 2010, 132. Liu, Y. Z. ; Kahn, R. A. ; Prestegard, J. H. Dynamic structure of membrane-anchored Arf center dot GTP. Nature Structural & Molecular Biology 2010, 17, 876-U128. Raman, S. ; Lange, O. F. ; Rossi, P. ; Tyka, M. ; Wang, X. ; Aramini, J. ; Liu, G. H. ; Ramelot, T. A. ; Eletsky, A. ; Szyperski, T. ; Kennedy, M. A. ; Prestegard, J. ; Montelione, G. T. ; Baker, D. NMR Structure Determination for Larger Proteins Using Backbone-Only Data. Science 2010, 327, 1014-1018. Liu, Y. Z. ; Prestegard, J. H. A device for the measurement of residual chemical shift anisotropy and residual dipolar coupling in soluble and membrane-associated proteins. Journal of Biomolecular Nmr 2010, 47, 249-258. Liu, Y. Z. ; Prestegard, J. H. Measurement of one and two bond N-C couplings in large proteins by TROSY-based J-modulation experiments. Journal of Magnetic Resonance 2009, 200, 109-118. Barb, A. W. ; Brady, E. K. ; Prestegard, J. H. Branch-Specific Sialylation of IgG-Fc Glycans by ST6Gal-I. Biochemistry 2009, 48, 9705-9707. Liu, Y. Z. ; Kahn, R. A. ; Prestegard, J. H. Structure and Membrane Interaction of Myristoylated ARF1. Structure 2009, 17, 79-87. DeMarco, M. L. ; Woods, R. J. ; Prestegard, J. H. ; Tian, F. Presentation of Membrane-Anchored Glycosphingolipids Determined from Molecular Dynamics Simulations and NMR Paramagnetic Relaxation Rate Enhancement. Journal of the American Chemical Society 2009, 132, 1334-1338. Liu, S. ; Meng, L. ; Moremen, K. W. ; Prestegard, J. H. Nuclear Magnetic Resonance Structural Characterization of Substrates Bound to the alpha-2,6-Sialyltransferase, ST6Gal-I. Biochemistry 2009, 48, 11211-11219. Kley, S. ; Hoenig, M. ; Glushka, J. ; Jin, E. S. ; Burgess, S. C. ; Waldron, M. ; Jordan, E. T. ; Prestegard, J. H. ; Ferguson, D. C. ; Wu, S. X. ; Olson, D. E. The impact of obesity, sex, and diet on hepatic glucose production in cats. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2009, 296, R936-R943. Nkari, W. K. ; Prestegard, J. H. NMR Resonance Assignments of Sparsely Labeled Proteins: Amide Proton Exchange Correlations in Native and Denatured States. Journal of the American Chemical Society 2009, 131, 5344-5349.