个人简介
Dr. Li obtained her Ph.D. degree from China Pharmaceutical University in 1999, and then
worked as a post-doctoral research fellow in Institute of Materia Medica of Chinese Academy of
Medical Sciences and Peking Union Medical College (CAMS & PUMC). In 2001, she was
sponsored by Japan Society for the Promotion of Science to work as a post-doctoral research
fellow in Niigata University, Japan. From 2003 to 2007, she engaged in the study of bioactive
compounds in The National Center for Drug Screening, Shanghai Institute of Materia Medica,
Chinese Academy of Sciences. Her research in The Chinese University of Hong Kong during the
period 2007 to 2011 mainly focused on the toxicity of natural products. She has rich experience
in the research of natural product chemistry, and has published more than 30 research articles in
number of international journals including Journal of Hepatology, PNAS, Molecular
Pharmaceutics, Journal of Natural Products and etc.
Education:
July, 1994, B. Sc. (West China University of Medical Sciences, Chengdu, Sichuan Province,
China )
July, 1999, Ph. D. (China Pharmaceutical University, Nanjing, Jiangsu Province, China)
Professional Chronology:
September, 1999 - October, 2001 Institute of Mataria Medica, CAMS & PUMC
November, 2001 - November, 2003 Niigata University, Japan
December, 2003 - October, 2007 The National Center for Drug Screening, Shanghai
Institute of Materia Medica, CAS
November, 2007 - August, 2011 The Chinese University of Hong Kong, Hong Kong
September, 2011-present Assistant Professor, Macau Institute for Applied Research
in Medicine and Health, Macau University of Science
and Technology
Teaching Subjects:
Natural Product Chemistry
研究领域
Natural Product Chemistry, including the isolation, structural elucidation, and structural
modification of natural products, and the qualification and quantification of bioactive natural
products and metabolites.
近期论文
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1) N. Li, Q. Xia, J.-Q. Ruan, et al. Hepatotoxicity and tumorigenicity induced by metabolic
activation of pyrrolizidine alkaloids in herbs. Curr Drug Metab, (Epub ahead of print)
2) G. Lin,* J.-Y. Wang,* N. Li, et al. Hepatic sinusoidal obstruction syndrome associated
with consumption of Gynura segetum. J Hepatol, 54, 666-673, 2011.
3) B. Ma, H. Zha, N. Li, et al. Effect of structural modification of α-aminoxy peptides on
their intestinal absorption and transport mechanism. Mol Pharmaceut, 8, 1073-1082, 2011.
4) Y. Zhou, N. Li, F.F.-K. Choi, et al. A new approach for simultaneous screening and
quantification of toxic pyrrolizidine alkaloids in some potential pyrrolizidine alkaloid
containing plants by using ultra performance liquid chromatography − tandem quadrupole
mass spectrometry. Anal Chim Acta, 681, 33-40, 2010.
5) X. Zhou, P.H.-H. Leung, N. Li, et al. Oral absorption and antitussive activity of
tuberostemonine alkaloids from the roots of Stemona tuberosa. Planta Med, 75, 575-580,
2009.
6) G. Lin, S.-L. Li, M. Li, N. Li, et al. Qianliguang (Senecio scandens) safety dilemma: dose
is the key? Planta Med, 75, 1107-1111, 2009.
7) G. Lin, Z. Zuo, N. Li, L. Zhang. Drug-Drug Interactions and Drug-Dietary Chemical
Interactions, In Oral Bioavailability: Basic Principles, Advanced Concepts and
Applications, Wiley Series in Drug Discovery and Development. John Wiley & Sons, Inc.,
Hoboken, USA, 2009.
8) N. Li,* J.-L. Wu, S. Xu, et al. Research progress on medicinal plants of Peperomia genus.
Recent Progress in Medicinal Plants, 20, 419-431, 2008.
9) N. Li,* J.-L. Wu, T. Hasegawa, et al. Bioactive Polyketides from Peperomia duclouxii. J
Nat Prod, 70, 998-1001, 2007.
10) N. Li,* J.-L. Wu, T. Hasegawa, et al. Bioactive Lignans from Peperomia duclouxii. J Nat
Prod, 70, 544-548, 2007.
11) G.-L. Zhang, N. Li,* Y.-H. Wang, Y.-T. Zheng, Z. Zhang, and M.-W. Wang. Bioactive
Lignans from Peperomia heyneana. J Nat Prod, 70, 662-664, 2007.
12) D.-S. Chen, J.-Y. Liao, N. Li, et al. A nonpeptidic agonist of glucagon-like peptide 1
receptors with efficacy in diabetic db/db mice. PNAS, 104, 943-948, 2007.
13) C.-H. Zhou, S. Zhang, M. Nanamori, Y. Zhang, Q. Liu, N. Li, et al. Pharmacological
characterization of a novel nonpeptide antagonist for formyl peptide receptor-like 1. Mol
Pharmacol, 72, 976-983, 2007.
14) J.-L. Wu, N. Li,* T. Hasegawa, et al. Bioactive secolignans from Peperomia
dindygulensis. J Nat Prod, 69, 790-794, 2006.
15) N. Li,* J.-L. Wu, T. Hasegawa, et al. Bioactive dibenzylbutyrolactone and
dibenzylbutanediol lignans from Peperomia duclouxii. J Nat Prod, 69, 234-239, 2006.
16) S. Xu, N. Li,* M.-M. Ning, et al. Bioactive compounds from Peperomia pellucida. J Nat
Prod, 69, 247-250, 2006.
17) M. Zhao, S.-J. Zhang, L.-W. Fu, N. Li, et al. Taraxasterane- and ursane-type triterpenes
from Nerium oleander and their biological activities. J Nat Prod, 69, 1164-1167, 2006.
18) P.-K. Yan, M. Nanamori, M.-L. Sun, C.-H. Zhou, N. Cheng, N. Li, et al. The
Immunosuppressant Cyclosporin A Antagonizes Human Formyl Peptide Receptor
through Inhibition of Cognate Ligand Binding. J Immunol, 177, 7050-7058, 2006.
19) J.-L. Wu, N. Li,* T. Hasegawa, et al. Bioactive tetrahydrofuran lignans from Peperomia
dindygulensis. J Nat Prod, 68, 1656-1660, 2005.
20) L.-W. Fu, S.-J. Zhang, N. Li, et al. Three new triterpenes from Nerium oleander and
biological activity of the isolated compounds. J Nat Prod, 68, 198-206, 2005.