Heinrichs, David - University of Western Ontario - Department of Microbiology and Immunology

个人简介

Dr. Heinrichs is a Professor in the Department of Microbiology & Immunology at the University of Western Ontario. He is also currently the Associate Director of the Centre for Human Immunology. Postdoctoral Fellow (1995-1998), University of Guelph, Guelph, Ontario. Studied under the guidance of Dr. Chris Whitfield, studying lipopolysaccharide biosynthesis and assembly in Escherichia coli PhD (1989-1995), Queen’s University, Kingston, Ontario. Studied under the supervision of Dr. Keith Poole, investigating iron acquisition in Pseudomonas aeruginosa. BSc, Hons. 1st Class (1985-1989). University of Manitoba, Winnipeg, Manitoba. Specialization in Microbiology. SELECTED HONOURS 2015-2017: University of Western Ontario Faculty Scholar 2012: Dean’s Award of Excellence, Schulich School of Medicine & Dentistry 2006: Fisher Award from the Canadian Society of Microbiologists 2001-2006 : Premier’s Research Excellence Award Recipient 2000-2005 : CIHR New Investigator Award Recipient

研究领域

The Heinrichs laboratory studies the pathogenesis of clinically-important species of staphylococci, most notably the human and animal pathogen Staphylococcus aureus. We use a wide range of molecular and biochemical tools to understand the molecular basis of disease-causation by these bacteria. S. aureus is capable of causing numerous types of infections in humans that range from mild to serious. Indeed, S. aureus can cause minor skin infections such as boils or it can cause more serious infections that result in clinical manifestations such as endocarditis, osteomyelitis, arthritis, septicemia, and toxic shock syndrome, among others, as well as infections of surgical wounds. What is more, S. aureus is known as one of the so-called superbugs, because of the pathogenic nature of the bacterium combined with the fact that it frequently acquires resistance to many currently used antibiotics. Methicillin resistant S. aureus, or MRSA, is one of the most notorious pathogens in the hospital environment and the spread of community acquired MRSA is now becoming prevalent.

近期论文

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Kaiser JC, Sen S, Sinha A, Wilkinson BJ and Heinrichs DE . 2016. The role of two branched-chain amino acid transporters in Staphylococcus aureus growth, membrane fatty acid composition and virulence. Molecular Microbiology 102: 850-864. Heilbronner S, Monk IR, Brozyna JR, Heinrichs DE, Skaar EP, Peschel A, Foster TJ. 2016. Competing for iron: duplication and amplification of the isd locus in Staphylococcus lugdunensis HKU09-01 provides a competitive advantage to overcome nutritional limitation. PLoS Genetics. 12: e1006246. Sheldon JR, Laakso HA, Heinrichs DE. 2016. Iron acquisition strategies of bacterial pathogens. Microbiology Spectrum. 4(2). Laakso HA, Marolda CL, Pinter TB, Stillman MJ and Heinrichs DE. 2016. A heme-responsive regulator controls synthesis of staphyloferrin B in Staphylococcus aureus. Journal of Biological Chemistry 291: 29-40. Flannagan RS, Heit B, and Heinrichs DE. 2016. Intracellular replication of Staphylococcus aureus in mature phagolysosomes in macrophages precedes host cell death, and bacterial escape and dissemination. Cellular Microbiology. 18: 514-535. Flannagan RS, Heit B, and Heinrichs DE. 2015. Antimicrobial mechanisms of macrophages and the immune evasion strategies of Staphylococcus aureus. Pathogens 4: 826-868. Sheldon JR and Heinrichs DE. 2015. Recent developments in understanding the iron acquisition strategies of gram positive pathogens. FEMS Microbiology Reviews. 39: 592-630. Alnaseri H, Arsic B, Schneider JE, Kaiser JC, Scinocca ZC, Heinrichs DE and McGavin MJ. 2015. Inducible expression of a resistance-nodulation-division-type efflux pump in Staphylococcus aureus provides resistance to linoleic and arachidonic acids. Journal of Bacteriology. Epub Mar 23, 2015. Hannauer M, Arifin AJ and Heinrichs DE. 2015. Involvement of reductases IruO and NtrA in iron acquisition by Staphylococcus aureus. Molecular Microbiology. Epub Mar 16, 2015 . Hannauer M, Sheldon JR and Heinrichs DE. 2015. Involvement of major facilitator superfamily proteins SfaA and SbnD in staphyloferrin secretion in Staphylococcus aureus. FEBS Letters. 589: 730-737. Kaiser JC, Omer S, Sheldon JR, Welch I and Heinrichs DE. 2015. Role of BrnQ1 and BrnQ2 in branched-chain amino acid transport and virulence in Staphylococcus aureus. Infection and Immunity. 83: 1019-1029.