Gunaratnam, Lakshman - University of Western Ontario - Department of Microbiology and Immunology

个人简介

Dr. Lakshman Gunaratnam is an Assistant Professor and Clinician-Scientist at the University of Western Ontario in the Department of Medicine and Microbiology & Immunology. He earned his Honours Bachelor of Science and Master of Science degrees at the University of Toronto, and graduated from medical school at the University of Ottawa. He completed a residency in internal medicine at the University of Ottawa, and fellowships in Nephrology and Transplantation at Brigham and Women's and Massachusetts General Hospitals, Harvard Medical School, Boston. He was later an associate physician at the Brigham and Women's Hospital, Boston prior to being recruited to London. Dr. Gunaratnam's clinical interest and expertise lies in acute kidney injury and renal transplantation. Dr. Gunaratnam's research program focuses on the role ischemia reperfusion injury plays in regulating innate immunity and inflammation in renal transplantation. His CIHR-funded basic science research laboratory is actively studying how injured kidney epithelial cells regulate inflammation by expressing Kidney Injury Molecule-1. Dr. Gunaratnam is the recipient of a KRESCENT New Investigator Award and the Schulich Clinician-Scientist Award. Dr. Gunaratnam hopes to develop novel therapeutic strategies to ameliorate ischemic acute kidney injury and prolong the lifespan of transplanted organs. 1996 Hon. Bachelor’s of Science, University of Toronto 1999 Master’s of Science (Immunology), University of Toronto 2002 Doctorate in Medicine, University of Ottawa Post-doctoral Clinical Training July 02- Jun 05 Residency in Internal Medicine, The Ottawa Hospital, University of Ottawa July 08- Jun 09 Fellowship in Nephrology, Harvard Medical School, Brigham Hospital l-Massachusetts General Hospital Joint Program July 09-Dec 09 Transplant Fellow, Harvard Medical School, Brigham and Women’s Hospital Post-doctoral Research Training Jan 02-Aug 05 Research Fellow, Department of Cellular and Molecular Medicine, University of Ottawa (Mentor: Dr. Stephen Lee, PhD) Aug 05-Jun 08 Research Fellow, Harvard Medical School, Brigham and Women’s Hospital (Mentor: Dr. Joseph V. Bonventre, MD, PhD)

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1. Nat Med. 2016 Feb;22(2):183-93. doi: 10.1038/nm.4012. Epub 2016 Jan 4. Apoptosis inhibitor of macrophage protein enhances intraluminal debris clearance and ameliorates acute kidney injury in mice. Arai S(1), Kitada K(1), Yamazaki T(1), Takai R(1), Zhang X(2), Tsugawa Y(1), Sugisawa R(1), Matsumoto A(1), Mori M(1), Yoshihara Y(1), Doi K(3), Maehara N(1), Kusunoki S(1), Takahata A(4), Noiri E(5), Suzuki Y(4), Yahagi N(3), Nishiyama A(6), Gunaratnam L(2,)(7), Takano T(8), Miyazaki T(1,)(9,)(10). 2. Am J Physiol Renal Physiol. 2015 Dec 23:ajprenal.00169.2015. doi: 10.1152/ajprenal.00169.2015. [Epub ahead of print]. G protein, 12 (Gα12) is a negative regulator of kidney injury molecule-1-mediated efferocytosis. Ismail O(1), Zhang X(2), Bonventre JV(3), Gunaratnam L(4). 3. J Urol. 2015 Dec;194(6):1806-15. doi: 10.1016/j.juro.2015.07.096. Epub 2015 Aug 1. Hydrogen Sulfide Treatment Mitigates Renal Allograft Ischemia-Reperfusion Injury during Cold Storage and Improves Early Transplant Kidney Function and Survival Following Allogeneic Renal Transplantation. Lobb I(1), Davison M(2), Carter D(3), Liu W(4), Haig A(4), Gunaratnam L(5), Sener A(6). 4. Am J Pathol. 2015 May;185(5):1207-15. doi: 10.1016/j.ajpath.2015.02.003. Epub 2015 Mar 7. Kidney injury molecule-1 protects against Gα12 activation and tissue damage in renal ischemia-reperfusion injury. Ismail OZ(1), Zhang X(2), Wei J(2), Haig A(3), Denker BM(4), Suri RS(5), Sener A(1), Gunaratnam L(6). 5. Lancet. 2015 Jan 31;385(9966):480. doi: 10.1016/S0140-6736(14)62352-7. Cardiac, renal, and central nervous system dysfunction with eosinophilia: eosinophilic granulomatosis with polyangiitis. Hemmett J(1), Qirjazi E(1), Weir MA(1), Moussa M(2), Landry YD(1), Gunaratnam L(3).