Gao, Yong - University of Western Ontario - Department of Microbiology and Immunology

个人简介

M.D., Ph.D. in infectious diseases. Department of Infectious Diseases, Union Hospital, Tongji Medical School, Huazhong University of Science and Technology, China 2001 M.S. in infectious diseases. Department of Infectious Diseases, Union Hospital, Tongji Medical School, Huazhong University of Science and Technology, China 1998 B.S. Anhui Medical University, Anhui Province, China 1991 Professional appointments: 2015-present; Assistant Professor. Department of Microbiology and Immunology, UWO 2016-present: Director, Retroviral Vector Core, Department of Microbiology and Immunology, UWO 2010-2015; Assistant Professor, Division of Infectious Diseases and HIV Medicine, Department of Medicine, CWRU 2012-2015; Assistant Professor, secondary appointment, Department of Molecular Biology and Microbiology, CWRU 1/2007-12/2009; Instructor, Division of Infectious Diseases and HIV Medicine, Department of Medicine, CWRU

研究领域

Identification of a safe and effective prophylactic vaccine to prevent HIV-1 infection is among the highest priorities in HIV/AIDS research. Limited immunogenicity and breadth of several vaccine candidates tested in clinical trials, and setbacks in efficacy trials for both antibody- and T cell-based vaccines, highlight the fact that major gaps exist in our basic understanding of how to develop a protective HIV-1 vaccine. We think that the major obstacle for an effective and protective vaccine is the extreme HIV-1 genetic diversity at both a regional level and in the global epidemic, so we are mainly focusing on developing multiple-valent anti-HIV vaccine by utilizing HIV-1 envelope recombinants, as well as parental HIV-1 strains. We are also working on vector design, immunization optimization, generate novel SHIVenv viruses, and screening for broadly neutralizing anti-HIV antibodies. In addition, our research work also involves HIV diversity, recombination and drug resistance.

近期论文

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Krebs KC, Tian M, Asmal M, Ling B, Nelson K, Henry K, Gibson R, Li Y, Han W, Shattock RJ, Veazey RS, Letvin N, Arts EJ and Gao Y. Macaque infection by one virus clone from a pool of diverse SHIVenv derived 1 from acute HIV-1 infections is not related to a defined phenotypic property. AIDS Research and Therapy. 2016 Nov 25;13(1):41 Choi E, Michalski CJ, Choo SH, Kim GN, Banasikowska E, Lee S, Wu K, An HY, Mills A, Schneider S, Bredeek UF, Coulston DR, Ding S, Finzi A, Tian M, Klein K, Arts EJ, Mann JF, Gao Y, and Kang CY. Demonstrated safety of a Phase 1 Clinical Trial with a Killed, Whole-HIV vaccine results in enhanced anti-HIV antibody responses in humans. Retrovirology. 2016 Nov 28;13(1):82. Asmal M, Lane S, Tian M, Nickle G, Venner C, Dirk B, Dikeakos J, Luedemann C, Mach L, Balachandran H, Buzby A, Rao S, Letvin N, Gao Y, and Arts EJ. ¬Pathogenic infection of Rhesus macaques by an evolving SIV-HIV derived from CCR5-using envelope genes of acute HIV-1 infections. Virology. 2016 Dec; 499:298-312 Luo Z, Ma L, Zhang L, Martin L, Wan Z, Warth S, Kilby A, Gao Y, Bhargava P, Li Z, Wu H, Meissner EG, Li Z, Kilby M, Liao G, Jiang W. Key differences in B cell activation patterns and immune correlates among treated HIV-infected patients versus healthy controls following influenza vaccination. Vaccine.2015.12.038 Bagaya BS, Vega JF, Tian M, Li Y, Krebs KC, Arts EJ and Gao Y. Bottlenecks for Generation of Functional HIV-1 Intersubtype Env Recombinants. Retrovirology. 2015 May 23;12(1):44. Rausch JW, Tian M, Li Y, Angelova L, Bagaya BS, Krebs KC, Qian F, Zhu C, Arts EJ, LeGrice SF, Gao Y. SiRNA induced HIV-1 PPT mutation and its influence on the viral fitness. PlosOne. 2015 Apr 10;10(4):e0122953. Chamanian M, Purzycka KJ, Ha J, McDonald D, Gao Y, Le Grice SFJ, Arts EJ. Additional sequences within 3’ end of gag are required for optimal packaging of HIV-1 genomic RNA. Cell. Host & Microbe. 2013. Feb 13; 13(2):181-92. King DF, Siddiqui AA, Buffa V, Fischetti L, Gao Y, Stieh D, McKay P, Rogers P, Ochsenbauer C, Kappes JC, Arts EJ, Shattock RJ. Mucosal Tissue Tropism and Dissemination of HIV-1 Subtype B Acute Envelope-Expressing chimeric virus. J Virol. 2012 Nov 7. Gao Y, Abreha M, Nelson KN, Baird H, Dudley DM, Abraha A, Arts EJ. Enrichment of intersubtype HIV-1 recombinants in a dual infection system using HIV-1 strain-specific siRNAs. Retrovirology. 2011 Jan 13; 8(1):5. Dudley DM, Gao Y, Nelson KN, Henry KR, Nankya I, Gibson RM, Arts EJ. A rapid yeast-based HIV-1 cloning s ystem to produce fully infectious HIV-1 containing any HIV-1 coding region. BioTechniques. 2009: 42 (6):458-467 Gao Y, Lobritz MA, Roth J, Abreha M, Nelson KN, Nankya I, Moore-Dudley DM, Abraha A, Gerson SL, Arts EJ. Targets of small interfering RNA restriction during human immunodeficiency virus type 1 replication. J Virol. 2008 Mar; 82(6):2938-51