Dekaban, Greg - University of Western Ontario - Department of Microbiology and Immunology

个人简介

Education - Honours B.Sc. in Biochemistry, Queen’s University - Ph.D. in Biochemistry, University of Western Ontario Training - Post-Doctoral training at the Frederick Cancer Research Facility Awards - National Cancer Institute of Canada Studentship - Morris Kroll Memorial Scholarship for Cancer Research - International Fogarty Post-Doctoral Fellowship - Medical Research Council of Canada Post-Doctoral Fellowship - Ontario Ministry of Health Career Scientist Award - Ontario Ministry of Health Career Scientist Award, renewed - University of Western Ontario President’s Occupational Health and Safety Award

研究领域

The research in my laboratory is centered in two major areas: 1. A focus of our research is to define the role of the CD11d CD18 integrin in leukocyte biology and inflammation of the central nervous system. Through the use of immunological, molecular and cell biological techniques, my laboratory is defining the phenotype and function of different monocyte subsets that infiltrate the central nervous system following traumatic injury. In addition, my laboratory is involved in developing a novel anti-inflammatory treatment for spinal cord injury that involves blocking leukocytes from infiltrating the site of injury from the blood. 2. The second focus on my research is the development of novel therapeutic vaccine approaches for cancer. The current emphasis is in developing dendritic cell-based therapeutic vaccines. The laboratory is working in collaboration with Dr. Paula Foster to develop real-time cellular magnetic resonance imaging techniques as a means to track dendritic cell migration in vivo in humans.

近期论文

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1. Bao, F., Bailey, C.S., Gurr, K.R., Bailey, S.I., Rosas-Arellano, M.P., Dekaban, G.A., and Weaver, L.C. Increased oxidative activity in human blood neutrophils and monocytes after spinal cord injury. Experimental Neurology 2009 215: 308-316. epub 2008/11/13. 2. Dekaban, G.A.*, Snir, J., Shrum, B., de Chickera, S., Willert, C., Said E.A., Sékaly, R.P., Foster, P.J. and O’Connell, P.J.* Semi-quantitation of mouse dendritic cell migration in vivo using cellular MRI. J. Immunotherapy, 32: 240-251 (2009) PMID: 19242346. * Co-senior authors. 3. Bao, F., Bailey, C.S., Gurr, K.R., Bailey, S.I., Rosas-Arellano, M.P., Brown, A., Dekaban, G.A. and Weaver, L.C. Human spinal cord injury causes specific increases in surface expression of Beta integrins on leukocytes. J. Neurotrauma. 2011: 28:269-280. 4. Bao, F., Brown, A., Dekaban, G.A., Omaña, V. and Weaver, L.C. Anti-CD11d integrin blockade reduces the systemic inflammatory response syndrome after spinal cord injury. Expt. Neurology (2011) 231: 272-283. 5. Zhang, X, de Chickera, S.N., Willert, C., Economopoulos, V., Noad, J., Rohani, R., Wang, A.Y., Leving, M.K., Scheid, E., Foley, R., Foster, P.J. and Dekaban, G.A. Non-invasive detection of the in vivo migration of human monocyte-derived dendritic cells into the popliteal lymph nodes of CB17/scid mouse with cellular MRI. Cytotherapy. (2011) 13:1234-1248. 6. *de Chickera, S.N., *Willert, C., Noad, J., Mallett, C., Foster, P.J. and Dekaban, G.A. Cellular MRI as a sensitive, non-invasive modality suitable for detecting differences between the migratory efficiencies of different DC populations in vivo. International Immun. (2011) 24: 29-41. 7. Mawhinney, L.A., *Thawer, S., Lu, W.-Y., van Roojen, N., Weaver, L.C., Brown, A. and Dekaban, G.A. Differential detection and distribution of microglial and hematogenous macrophage populations in the injured spinal cord of the lys-EGFP-ki transgenic mouse. J Neuropathol Exp Neurol. (2012) 71: 180-197.