Cairns, Ewa - University of Western Ontario - Department of Microbiology and Immunology

研究领域

Our laboratory is interested in rheumatic autoimmune diseases. Specifically, our current research focuses on the pathogenesis of Rheumatoid Arthritis (RA). We are studying the role of MHC class II molecules as well as auto-antigens (e.g.citrullinated proteins) in the development of this disease. Our research is performed using human RA clinical specimens and humanized (MHC class II) tg mice as animal model for RA.

近期论文

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Hill JA, Sette A, Jevnikar AM, Bell DA, CAIRNS E. The conversion of arginine to citrulline allows for high affinity peptide interaction with the Rheumatoid Arthritis associated HLA-DRB1*0401 MHC class II molecules. J Immunol. (Cutting Edge), 171:538-541,2003. Hill JA, Al-Bishri J, Gladman DD, CAIRNS E, Bell DA. Serum Autoantibodies that Bind Citrullinated Fibrinogen are Frequently Found in Patients with Rheumatoid Arthritis. J Rheumatol., 33:2115-2119, 2006. Hill JA, Bell DA, Brintnell W, Yue D, Wehrli B, Jevnikar AM, Lee DA, Hueber W, Robinson WH, CAIRNS E. Arthritis induced by post-translationally modified (citrullinated) fibrinogen in DR4-IE transgenic mice. J Exp Med. 205:967-79, 2008. Chau TA, McCully ML, Brintnell W, An G, Kasper KJ, Haeryfar MSM, McCormick JK, CAIRNS E, Heinrichs DE, Madrenas J. Toll-like receptor 2 ligands on the staphylococcal cell wall downregulate superantigen-induced T cell activation and prevent toxic shock syndrome. Nature Med. 15:641-648, 2009. Yue D, Brintnell W, Mannik LA, Christie DA, Haeryfar SMM, Madrenas J, Chakrabarti S, Bell DA, CAIRNS E. CTLA4-Ig blocks the development and progression of citrullinated fibrinogen-induced arthritis in DR4 tg mice. Arthritis & Rheum. 62:10:2941-52, 2010. Kinloch AJ, Alzabin S, Brintnell W, Wilson E, Barra L, Wegner N, Bell DA, CAIRNS E, Venables PJ. Immunisation with Porphyromonas gingivalis enolase induces autoimmunity to mammalian a-enolase and arthritis in DR4-IE transgenic mice. Arthritis & Rheum. 63(12):3818-23. doi: 10.1002/art.30639, 2011. Barra L, Scinocca M. Saunders S, Bhayana R, Rohekar S, Racape M, Summers K, Coles R, CAIRNS E, Bell DA. Anti-Citrullinated Protein Antibodies (ACPA) in Unaffected First Degree Relatives of Rheumatoid Arthritis Patients. Arthritis & Rheum. 2013 Feb 28.doi:10. 1002/art.37911. [Epub ahead of print]