个人简介

Ph.D. University of Toronto, 2010 B.A. University of Toronto, 2005

研究领域

Analytical Chemistry/Inorganic Chemistry/Organic Chemistry/Physical Chemistry/Biological Chemistry/Chemical Education/Computational/Theoretical Chemistry/Environmental/Atmospheric Chemistry/Materials Chemistry and Nanoscience

Research in the Hili group is inspired by nature and operates at the interface of chemistry and biology. Our efforts rely upon expertise in synthetic chemistry, polymer science, and molecular biology to mimic the approaches nature uses to solve complex problems with simple solutions. Our approach to science requires a diverse background of researchers from various scientific disciplines, generating a collaborative atmosphere for students, while garnering an expanded knowledge of the biological and chemical sciences. Our inspiration from nature is the use of nucleic acids as a central blueprint, be it in the form of an information carrier, a molecular scaffold, or a functional polymer. Research projects in the Hili Group fall within the three areas below, contact Ryan for more information about research opportunities.

近期论文

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21- Hook, K. D.; Chambers, J.; Hili, R. "DNA-Encoded Libraries for Small-Molecule Catalyst Discovery" Submitted 2017 20- Lei, Y.; Hili, R. "Structure-Activity Relationships of the ATP cofactor in Ligase-Catalysed Oligonucleotide Polymerisations" Org. Biomol. Chem. 2017, 15, 2349–2352. 19- Guo, C.; Hili, R. "Fidelity of the DNA Ligase-Catalyzed Scaffolding of Peptide Fragments on Nucleic Acid Polymers" Bioconjugate Chem. 2017, 28, 314–318. 18- Kong, D.‡; Lei, Y.‡; Yeung, W.; Hili, R. "Enzymatic Synthesis of Sequence-Defined Synthetic Nucleic Acid Polymers with Diverse Functional Groups" Angew. Chem. Int. Ed. 2016, 55, 13164–13168. This work was recommended in F1000Prime Access the recommendation on F1000 17- Kong, D.; Yeung, W.; Hili, R. "Generation of Synthetic Copolymer Libraries by Combinatorial Assembly on Nucleic Acid Templates" ACS Comb. Sci. 2016, 18, 355–370. (Invited Review and Cover Issue) 16- Lei, Y.; Kong, D.; Hili, R. "A High-Fidelity Codon Set for the T4 DNA Ligase-Catalyzed Polymerization of Modified Oligonucleotides" ACS. Comb. Sci. 2015, 17, 716–721. 15- Guo, C. Watkins, C. P. Hili, R. "Sequence-Defined Scaffolding of Peptides on Nucleic Acid Polymers" J. Am. Chem. Soc. 2015, 137, 11191–11196