个人简介

Selected Awards and Distinctions Award of Recognition. Western Engineering, 2016 Edward G Pleva Excellence in Teaching Award. University of Western Ontario, 2015 Faculty Scholar Award. University of Western Ontario, 2014 Bikila Professional Excellence Award, 2014 R. Mohan Mathur Award for Excellence in Teaching, Western Engineering, 2011 Early Researcher Award. Ontario Ministry of Research and Innovation, 2007 Selected Professional Activities 2014: Guest Editor, Journal of Biomaterials and Tissue Engineering 2011- Editorial Board Member, Journal of Biomaterials and Tissue Engineering 2012 - Academic Editor - BioMed Research International 2014- NSERC Discovery Grant Evaluation Group (Member and Co-chair for Materials and Chemical Engineering) 2010- Session Organizer and Chair for multiple Biomaterials conferences 2015- Graduate Chair, Department of Chemical and Biochemical Engineering, Western 2014- Professor, Department of Chemical and Biochemical Engineering, Western 2014-2015: Acting Chair, Department of Chemical and Biochemical Engineering, Western 2009-2014: Associate Professor & Associate Chair, Department of Chemical and Biochemical Engineering, Western 2003-2009: Assistant Professor, Department of Chemical and Biochemical Engineering, Western © 1878 - 2017 Western University Department of Chemical and Biochemical Engineering Thompson Engineering Building, Western University London, Ontario, Canada, N6A 5B9 Tel: 519-661-2131 cbechair@uwo.ca Privacy | Web Standards | Terms of Use | Accessibility Key Topics: Undergraduate Graduate People Research Popular Resources: Western Mail OWL Registrar Libraries Maps Western University Crest

研究领域

Development of interactive biodegradable biomaterials Tissue engineering is an emerging discipline with a goal to regenerate diseased tissues and organs by applying concepts of materials design, engineering, and life sciences to study the biological processes associated with the development of tissues. Thus the design of suitable biomaterials for scaffolding is at the heart of tissue engineering and regenerative medicine research. In order to achieve successful regeneration of damaged tissues based on the tissue engineering approach, we are designing advanced natural and synthetic biodegradable biomaterials with controlled biomechanical and structural details. These biomaterials will further be imprinted with biological signals for fabricating tissue-engineered arteries. New 3D scaffold fabrication methods The adhesion of cells to the scaffold is the first event in tissue engineering. Subsequent cellular events such as phenotypic expression, differentiation, and ECM secretion depend on this critical event. In this area we are focusing on understanding the interactions between cells and scaffolds that modulate cellular functions such as adhesion, migration, proliferation, differentiation and extracellular matrix remodeling for the repair of cardiovascular injuries. Vascular cells interaction with 3D scaffolds Tissue engineering is an emerging discipline with a goal to regenerate diseased tissues and organs by applying concepts of materials design, engineering, and life sciences to study the biological processes associated with the development of tissues. Thus the design of suitable biomaterials for scaffolding is at the heart of tissue engineering and regenerative medicine research. In order to achieve successful regeneration of damaged tissues based on the tissue engineering approach, we are designing advanced natural and synthetic biodegradable biomaterials with controlled biomechanical and structural details. These biomaterials will further be imprinted with biological signals for fabricating tissue-engineered arteries. Mass transfer studies in Tissue Engineering The approach of tissue engineering constitutes an important engineering challenge because of the difficulty to grow cells in high density, due to mass transfer limitations (delivery of nutrients removal of metabolic waste products). The major mass transfer challenge in tissue engineering arises from the inability to deliver sufficient oxygen. As a result, tissue engineered constructs frequently have an inhomogeneous structure consisting of a dense layer of cells and extracellular matrix concentrated along the periphery, and a necrotic interior region. Such an inhomogeneous structure may limit the initial mechanical functionality and subsequent in vivo function of grafts of clinically relevant size. We are currently working on addressing this issue in a novel way. Our ultimate goal is to develop cardiovascular tissue substitutes using novel biomaterial scaffolds that incorporate vascular cells and extracellular matrix proteins in a state-of-the-art bioreactor.

The research theme in the Mequanint Lab is in the areas of polymeric biomaterials, tissue engineering and regenerative medicine. Our earlier studies focused on polyurethane-derived biomaterials but it evolved to include hydrogels, biodegradable poly(ester amide)s, and polyphosphazenes. In addition to the above, the lab has active research in the utility of naturally-occurring gels and radiation tracer molecules (tetrazolium derivatives) as radiation dosimeter for quality assurance of cancer treatment. 

近期论文

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J.P. Theron, J.H. Knoetze, Ronald D. Sanderson, R. Hunterd, Kibret Mequanint, Peter Zilla and Deon Bezuidenhout. Modification, Crosslinking and Reactive Electrospinning of Thermoplastic Medical Polyurethane for Vascular Graft Applications. Acta Biomaterialia 6, 2434-2447; 2010. Alpesh Patel and Kibret Mequanint. Swelling kinetics of physically crosslinked polyurethane-block-polyacrylamide hydrogels. IEEE Preprints. DOI: 10.1109/NEBC.2009.4967632; 2009. Alpesh Patel, Kibret Mequanint. The Kinetics of Dithiocarbamate-mediated Polyurethane-block-Poly(methyl methacrylate) Polymers. Polymer 50; 4464-4470; 2009. Stéphanie Grenier, Martin Sandig, Kibret Mequanint. Smooth Muscle alpha-actin and Calponin Expression and, Extracellular Matrix Production of Human Coronary Artery Smooth Muscle Cells in 3D Scaffolds. Tissue Engineering A. 15:3001-3011, 2009. Katelyn M. Atkins, David Lopez, Darryl Knight, Kibret Mequanint, and Elizabeth R. Gillies. A Versatile Approach for the Syntheses of Poly(ester amide)s with Pendant Functional Groups. J. Polym Sci. Polym Chem. 47:3757-3772, 2009. Stéphanie Grenier, Martin Sandig, David W. Holdsworth, Kibret Mequanint. Interactions of coronary artery smooth muscle cells with 3D porous polyurethane scaffolds. J. Biomed Mater Res 89A: 293-303, 2009. Alpesh Patel and Kibret Mequanint. Syntheses and Characterization of Physically Crosslinked Hydrogels from Dithiocarbamate-derived Polyurethane Macroiniferter. J. Polym Sci. Polym Chem. 46, 6272-6284, 2008. Matthew A. De Wit, Zixi Wang, Katelyn M. Atkins, Kibret Mequanint and Elizabeth R. Gillies. Syntheses, Characterization and Functionalization of Poly(ester amide)s with Pendant Amine Functional Groups. J. Polym Sci. Polym Chem. 46, 6376-6392, 2008. Sara Alibeik, Amin Rizkalla, Kibret Mequanint. Protein adsorption and platelet adhesion onto ion-containing polyurethane biomaterials. J. Biomater Sci: Polym Edn, 18, 1195–1210, 2007. Alpesh Patel, Kibret Mequanint. Novel physically crosslinked polyurethane-block-poly(Vinyl Pyrrolidone) hydrogel biomaterials. Macromol Biosci 7, 727–737, 2007. Stephanie Grenier, Martin Sandig, and Kibret Mequanint. Vascular smooth muscle cells infiltrate 3D porous polyurethane scaffolds when coated with basement membrane matrix proteins. Published as "Abstracts submitted to the Vascular Matrix Biology and Bioengineering Workshop Presented March 15–18, 2007 in Whistler, British Columbia Sponsored by the North American Vascular Biology Organization Co-sponsored by the Canadian Society of Atherosclerosis, Thrombosis and Vascular Biology". J Tissue Eng Regen Med. 1(3); 218-242, 2007 Sara Alibeik, Amin Rizkalla, Kibret Mequanint. The effect of thiolation on the mechanical and protein adsorption properties of polyurethanes. Eur. Polym. J. 43(4):1415-1427, 2007. Stéphanie Grenier, Martin Sandig, Kibret Mequanint. Polyurethane biomaterials for fabricating 3D porous scaffolds and supporting vascular cells. J. Biomed Mater Res 82A:802-809, 2007. Alpesh Patel, Benjamin Fine, Martin Sandig, Kibret Mequanint. Elastin biosynthesis: The missing link in tissue-engineered blood vessels. Cardiovascular Research. 71(1):40-49, 2006. Kibret Mequanint, Alpesh Patel, Deon Bezuidenhout. Synthesis, swelling behavior and biocompatibility of novel physically crosslinked polyurethane-block-poly(glycerol methacrylate) hydrogels. Biomacromolecules, 7(3):883-891, 2006. Kibret Mequanint, Ronald Sanderson. Hydrolytic-stability of nano-particle polyurethane dispersions: Implications to their long-term use. Eur. Polym. J. 42, 1145-1153, 2006. Kibret Mequanint, Heather Sheardown. 2-Methacryloyloxyethyl N-butylcarbamate: A new comonomer for hydrogel syntheses with optimum hydrophilic and mechanical properties for biomedical applications. J. Biomaterials Science: Polymer Edition, 16 (10) 1303-1318, 2005. Kibret Mequanint, Ronald Sanderson. Nano-structure phosphorus-containing polyurethane dispersions: synthesis and crosslinking with melamine formaldehyde resin. Polymer, 44, 2631-2639, 2003. Kibret Mequanint, Ronald D. Sanderson. Ultraviolet (UV) curing of phosphated polyurethane-acrylic Dispersions. Macrom Symp. 193, 169 – 186, 2003. Kibret Mequanint, Ronald D. Sanderson. Adhesion properties of phosphate- and siloxane-containing polyurethane dispersions to steel: An analysis of the metal–coating interface. J. Appl Polym Sci. 88(4) 900-907, 2003. Kibret Mequanint, Ronald D. Sanderson. Self-assembling metal coatings from phosphated and siloxane-modified polyurethane dispersions: An analysis of the coating–air interface. J Appl Polym Sci. 88(4): 893–899, 2003. Harald Pasch, Kibret Mequanint, Jorg Adrian. Two-dimensional chromatography of complex polymers. e-Polymers 5, 1-19, 2002. Kibret Mequanint, Ronald D. Sanderson, Harald Pasch. Phosphated polyurethane–acrylic nano-particles: Synthesis, rheological properties and wetting behavior. Polymer, 43, 5341-5346, 2002. Kibret Mequanint, Ronald D. Sanderson. Phosphated polyurethane dispersions: Synthesis, emulsification mechanisms and the effect of the neutralizing base. Macromol Symp. 178, 117-130, 2002. Kibret Mequanint, Ronald D. Sanderson, Harald Pasch. Thermogravimetric study of phosphated polyurethane ionomers. Polym Degrad Stab. 77, 121-128, 2002.