Guillemette, Guy - University of Waterloo

个人简介

Guy Guillemette carries out research in the area of biochemistry. His research focuses on the synthesis of nitric oxide by nitric oxide synthase. Nitric oxide is an important endogenous messenger in a variety of physiological and pathophysiological processes. Protein structure and function nitric oxide synthase calmodulin enzymology biophysics Editorial Board member, Biochemical Research Letters, 2009-present Journal of Biomedicine and Biotechnology, 2008-present (GWC)2 Director, 2012-2015 Science Faculty Council, 2012-2015 Chemistry Safety committee, 2015 Graduate Officer, 2009-2012 IBMB Director, 2009-2012 Graduate advisor committee, 2009-2012 (GWC)2 Coordinating Committee, 2005-2012 Undergraduate Relations Committee, 2003-2012 1988 PhD, Biochemistry, University of Toronto 1981 BSc, Biochemistry, University of Toronto

研究领域

Nitric Oxide (NO) is an important regulator of numerous essential physiological processes like blood pressure, neurotransmission, insulin release, memory storage and the immune response. In addition, NO is involved in a variety of serious pathophysiological processes including septic shock, atherosclerosis, diabetes, as well as myocardial and cerebral ischemia. The biogenesis of NO is catalyzed by Nitric Oxide Synthase (NOS) enzymes. The long-term goal of our research program is to understand the regulation and mechanism of the NOS enzymes.

近期论文

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Piazza, M., Guillemette,* J.G., Dieckmann*, T. (2015) Dynamics of nitric oxide synthase-calmodulin interactions at physiological concentrations. Biochemistry 54, 1989-2000. *-corresponding authors Piazza, M., Taiakina, V., Guillemette, S.R., Guillemette,* J.G., Dieckmann*, T. (2014) Solution Structure of Calmodulin bound to the target peptide of Endothelial Nitrogen Oxide Synthase phosphorylated at Thr495. Biochemistry 53, 1241-9. *-corresponding authors Astashkin, A.,Chen, L., Zhou, X., Li, H., Poulos, T., Liu, Ke, J., Guillemette, J. G., Feng, C. (2014) Pulsed Electron Paramagnetic Resonance Study of Domain Docking in Neuronal Nitric Oxide Synthase: The Calmodulin and Output State Perspective. J. Phys Chem A 118, 6864-72 Taiakina V, Boone AN, Fux J, Senatore A, Weber-Adrian D, Spafford JD, Guillemette JG. (2013) The calmodulin-binding, short linear motif, NSCaTE is conserved in L-type channel ancestors of vertebrate Cav1.2 and Cav1.3 channels. PLOS ONE 8, e61765, 16 pages Labbé G, Krismanich AP, de Groot S, Rasmusson T, Shang M, Brown MD, Dmitrienko GI, Guillemette JG. (2012) Development of metal-chelating inhibitors for the Class II fructose 1,6-bisphosphate (FBP) aldolase. J. Inorg. Biochem 112, 49-58.