Dieckmann, Thorsten - University of Waterloo

个人简介

Thorsten Dieckmann's research interests include the biophysics of RNA, structure and function of RNA and proteins, high resolution NMR spectroscopy, catalysis, drug design, viral infections, RNA world and the origin of life. Thorsten is the Director of the Insititute of Biochemistry & Molecular Biology. Nuclear Magnetic Resonance (NMR)-spectroscopy Ribonucleic acid (RNA) and protein structure RNA-protein interactions RNA catalysis Viral infections Cellular defense mechanisms Advisor, Biochemistry Program, 2014-present GWC2 steering committee, 2011-present Executive Committee, 2010-present Member of the Board, Faculty of Science Foundation, 2010-2014 Executive Director, Faculty of Science Foundation, 2009-2010 1993 Dr. rer. nat., Technical University of Braunschweig, Germany 1991 Dipl. Chem., Technical University of Braunschweig, Germany

研究领域

Thorsten Dieckmann's research focuses on two areas of RNA related research: Small RNAs with interesting ligand binding or catalytic properties and the structure and function of RNA-protein complexes. The structure determination of RNA and RNA-protein complexes by NMR requires the development and application of heteronuclear, multi-dimensional NMR techniques in combination with complete or specific 13C, 15N, and 2H labeling of the molecules under investigation. In addition in vitro selection can be applied to find RNAs with high affinities for target proteins or modules of these proteins. The study of ion-binding to RNA and the investigation of the molecular dynamics of free RNAs and their complexes will add to a more complete picture of the structure and function of RNA and RNA-protein interactions on a molecular level.

近期论文

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Piazza M*, Guillemette JG, Dieckmann T. (2016). Chemical Shift Assignments of Calmodulin constructs with EF hand mutations. Biomolecular NMR Assignments. In press. Piazza, M., Guillemette, G., Dieckmann, T. (2015). Chemical Shift perturbations induced by residue specific mutations of CaM interacting with NOS peptides. Biomolecular NMR Assignments, 9:299-302. Piazza M., Guillemette G, Dieckmann T. (2015). Dynamics of Nitric Oxide Synthase – Calmodulin Interactions at Physiological Calcium Concentrations. Biochemistry, 54:1989-2000. Piazza, M., Taiakina, V., Guillemette, S.R., Guillemette, J.G., Dieckmann, T. (2014) "Solution Structure of Calmodulin bound to the target peptide of Endothelial Nitric Oxide Synthase phosphorylated at Thr495", Biochemistry 53: 1241–1249. Da Costa, J. B., Andreiev, A. I., and Dieckmann, T. (2013) “Thermodynamics and Kinetics of Adaptive Binding in the Malachite Green RNA Aptamer”, Biochemistry 52: 6575-6583.