Dixon, Brian - University of Waterloo

个人简介

Professor Brian Dixon carries out research in fish immunology and is a world expert on environmental effects on fish immune systems. Environment and Immunology Comparative Immunology Antigen Presentation Diagnostic Assays 1993 PhD Biology, Dalhousie University 1988 MSc Molecular Biology and Genetics, University of Guelph 1985 BSc Honours Biology, Wilfred Laurier University Journal Editorship Developmental and Comparative Immunology, Editorial Board Animal and Plant Immunology, Elsevier Reference Collection, Section Editor Committees NSERC Committee 1502 Ex Vivo Science Advisory Board Vitameter Science Advisory Board Canada Research Chair College of Reviewers Treasurer, Pan-American Marine Biotechnology Association Board member, International Society for Fish and Shellfish Immunology

研究领域

Research in Professor Dixon's laboratory is directed towards characterizing fish immune systems at the molecular level. A detailed knowledge of the molecules used as signals and receptors in the mammalian immune system has allowed more effective control of disease through vaccines and drugs. However, only a handful of immunologically important molecules have been isolated from fish, despite the growing need for vaccines and drugs to control diseases in aquaculture. A deeper knowledge of the molecules involved in teleost immune systems also provides insight into the evolution and function of equivalent molecules in mammalian immune systems. To date Professor Dixon's research program has focused on the Major Histocompatibility Complex (MHC) receptors. These molecules are present on the surface of every cell in the body of vertebrates and are the key molecules which decide what belongs to the body and what is a pathogen. Professor Dixon was the first researcher to isolate an expressed MHC gene from fish, and produced the antibodies that allowed the first demonstration that they are present on the surface of fish cells. MHC receptors are highly polymophic and Professor Dixon has performed experiments to measure the evolution of MHC polymorphism in a fish population. Dr. Dixon has also shown that fish immune systems shut down in cold temperatures making them more susceptible to disease.

近期论文

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Gilbertson, M.K., Haffner, G.D., Drouillard, K. Albert, A., and Dixon, B. Immunosuppression in the Northern leopard frog (Rana pipiens) induced by pesticide exposure. Envir. Tox. Chem 22(1): 101-110. Dixon, B., Shum, B.P.S. , Adams, E.J., Magor, K.E., Hedrick, R.P., Muir, D.G. and Parham, P. CK-1, a putative chemokine of rainbow trout (Oncorhynchus mykiss). Immunological Reviews. 166: 345-352. Stet R.J.M., Kruiswijk, C.P. and Dixon, B. Major histocompatibility lineages and immune gene function in teleostean fishes: The road less taken. Invited Review. Critical Reviews in Immunology. 23(5&6): 441-471. Nath, S. Fujiki, K., Kales S.C. and Dixon B. Major Histocompatibility class II genes in rainbow trout (Oncorhynchus mykiss) exhibit temperature dependent downregulation Immunogenetics, 58 443-453. Sever, L., Vo, NTK, Lumsden, J. Bols NC and Dixon B Induction of rainbow trout MH class I and accessory proteins by viral haemorrhagic septicaemia virus. Molecular Immunology 59: 154–162.