Craig, Paul M - University of Waterloo

个人简介

Dr. Craig's research program is aimed at gaining a fundamental understanding of multiple, mixed stressors found within the environment and the impact its having upon aquatic species, specifically model (i.e., zebrafish) and native (i.e., rainbow darter) fish species. Dr. Craig's research takes an integrative approach, crossing all levels of biological organization, from epigenetic regulation (the mechanisms controlling how the genome expresses itself) to whole animal responses, to making predictions regarding the impact of mixed stressors on species health and abundance. Comparative and environmental animal physiology Phenotypic responses to multiple environmental stressors Molecular and epigenetic analysis, including microRNA and methylation profiling Energetics and metabolism 2014 Postdoctoral Fellowship, University of Ottawa 2009 PhD Comparative Physiology, McMaster University 2004 MSc Comparative Physiology, University of Guelph 2001 BSc Zoology, University of Guelph Journal Editorship International Editorial Board; Comparative Biochemistry & Physiology Review Editor for Animal Physiology Section; Reference Module in Life Sciences Professional Society Membership Canadian Society of Zoologist Society of Environmental Toxicology and Chemistry American Physiological Society Society of Experimental Biology University of Waterloo Service Chair; Biology Outreach Vice-Chair; Animal Care Committee Faculty of Science Representative; Bridges Public Lecture Series Co-organizer; Biology Seminar Series

研究领域

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Dr. Paul Craig's current research focuses on abiotic factors associated with climate change (temperature/hypoxia) in combination with emerging organic pollutants (pharmaceuticals), which have been demonstrated to target numerous fish species. A unique and novel aspect of Dr. Craig's research is examining the epigenetic mechanisms driving the altered phenotypes found in teleosts exposed to multiple stressors. Epigenetics is defined by examining the inheritance of variation beyond changes in DNA sequence. Epigenetic regulation, through DNA methylation, histone modification, and non-coding RNA may profoundly alter transcriptional and translational effects of gene expression, and it is now clear that these mechanisms are influenced by environmental stressors, both natural and anthropogenic, acting as the interface between the genome and the environment. Dr. Craig uses a number of different techniques to address these questions, including next-generation sequencing, qPCR and microarray analysis, cell culture, protein abundance and enzymatic activity, cell respiration and reactive oxygen species production, and measurements of whole animal metabolism and performance.