个人简介

Member, Ottawa-Carleton Institute of Biology (OCIB) Member, Ottawa-Carleton graduate program in Chemical and Environmental Toxicology (CET) Member, Centre for Advanced Research in Environmental Genomics (CAREG)

研究领域

Dr. White's research investigates the sources, fate and hazards of mutagenic contaminants in complex environmental matrices (e.g., soil, cigarette smoke, cannabis smoke, diesel emissions). His group uses a variety of chemical, biochemical, genetic and genomic technoqies to isolate and identify mutagenic substances in environmental samples, investigate the toxicological properties of these substances, and assess the risks of pathophysiological changes and adverse health outcomes.

Our laboratory employs a variety of strategies and tools to investigate the sources, fate and hazards of mutagenic and carcinogenic contaminants; in particular those that are components of complex mixtures in complex environmental matrices (e.g., urban air, vehicle, contaminated soils, tobacco smoke, cannabis smoke). More specifically, our research interests include: applied genetic toxicology for regulatory decision-making, assessment of excess lifetime cancer risk posed by complex mixtures of environmental carcinogens, molecular biomarkers of mutagen exposures and/or effects, genomic and proteomic methods for biomarker discovery, transgenic rodent systems for mutagenicity assessment, population-level manifestations of genotoxic/carcinogenic effects in feral biota. Current research includes: Comparative assessments of the mutagenic hazard posed by cigarette smoke condensates from modified-risk tobacco products. The mutagenic hazard and toxicological mode-of-action of cannabis smoke condensate. Quantitative modelling of genotoxicity dose- and concentration response functions for determination of points of departure (PODs), including Td and Benchmark Dose. In vitro assessment of chromosomal damage in cultured animal cells via automated microscopy. New technologies for assessment of genotoxicity, including the Pig-a mutation assay, and transgenic rodent assays in vitro and in vivo. The mutagenic and carcinogenic hazards of polycyclic aromatic hydrocarbons (PAHs) and complex PAH mixtures. The toxicological activity of diesel engine emissions generated under a variety of fuel formulation and aftertreatment scenarios. The genotoxic activity of azo substances, including azo dyes and colorants.

近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Jacobsen, N.R., White, P.A., Gingerish, J., Møller, P., Saber, A.T., Vogel, U., Wallin, H. Mutation spectrum in FE1-MutaTMMouse lung epithelial cells exposed to nanoparticulate carbon black. Environmental & Molecular Mutagenesis, in press, 2011 Bourdon, J.A., Bazinet, T.M., Arnason, T.T., Kimpe, L.E., Blais, J.M., White, P.A. Polychlorinated biphenyls (PCBs) contamination and aryl hydrocarbon receptor activity of Omega-3 fatty acid supplements: implications for daily intake of dioxins and PCBs. Food & Chemical Toxicology, in press, 2010 Chen, G., Gingerich, J., Soper, L., Douglas, G.R., White, P.A. Induction of lacZ mutations in MutaTMMouse primary hepatocytes. Environmental & Molecular Mutagenesis 51: 330-337, 2010 Doyle, J.R., Blais, J.M., White, P.A. Mass balance soil ingestion estimating methods and their application to inhabitants of rural and wilderness areas: A critical review. Science of the Total Environment 408: 2181-2188, 2010 Maertens, R.M., White, P.A., Rickert, W., Levasseur, G., Douglas, G.R., Bellier, P.V., McNamee, J.P., Thuppal, V., Walker, M., Desjardins, S. The genotoxicity of mainstream and sidestream cannabis and tobacco smoke condensate. Chemical Research in Toxicology, 22: 1406-1414, 2009