Trudeau, Vance L. - University of Ottawa

个人简介

Professor Trudeau holds the University of Ottawa Research Chair in Neuroendocrinology. His group's research is directed towards understanding how the vertebrate brain regulates anterior pituitary hormones that control sexual development and reproduction using fish and frog models. Applications of this basic research include spawning induction methods for endangered amphibians. More recent research is beginning to examine the hormones and neurotransmitters that regulate neuroestrogen synthesis. The team also studies the effects of sex steroids and pollutants (pharmaceuticals, pesticides, petroleum products) on neuroendocrine processes in fish and frogs. Other research examines the effects of such pollutants on sexual development and metamorphosis in frogs. This concept is called endocrine disruption. This has important implications for environmental and human health because many of these hormonal systems are conserved across species, including humans.

研究领域

The long-term objective of the TeamEndo research program is to understand how the brain and pituitary transduce environmental and physiological signals into changes in reproductive function. A deep understanding of neuroendocrinology is fundamental to our understanding of successful vertebrate reproduction under normal conditions or when the environment is under stress from pollution. More recent research is beginning to examine the hormones and neurotransmitters that regulate stem-like neurosteroidogenic radial glia. The team studies the effects of sex steroids and pollutants (pharmaceuticals, pesticides, petroleum products) on neuroendocrine processes in fish and frogs using both in vivo and in vitro approaches. Other research examines the effects of such pollutants on sexual development and metamorphosis in frogs. The work has shown that the brain is a major target for the actions of contaminants and that these disrupt normal development and reproduction. Such research has helped to shape the emerging field of “neuroendocrine disruption.”

近期论文

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Clulow J, Trudeau VL, Kouba AJ. Amphibian declines in the twenty-first century: why we need assisted reproductive technologies. Adv Exp Med Biol. 2014;753:275-316 Hamilton CK, Navarro-Martin L, Neufeld M, Basak A, Trudeau VL. Early expression of aromatase and the membrane estrogen receptor GPER in neuromasts reveals a role for estrogens in the development of the frog lateral line system. Gen Comp Endocrinol. 2014 Sep 1;205:242-50. Duarte-Guterman P, Navarro-Martín L, Trudeau VL. Mechanisms of crosstalk between endocrine systems: regulation of sex steroid hormone synthesis and action by thyroid hormones. Gen Comp Endocrinol. 2014 Jul 1;203:69-85. Xing L, Goswami M, Trudeau VL. Radial glial cell: critical functions and new perspective as a steroid synthetic cell. Gen Comp Endocrinol. 2014 Jul 1;203:181-5. León-Olea M, Martyniuk CJ, Orlando EF, Ottinger MA, Rosenfeld CS, Wolstenholme JT, Trudeau VL. Current concepts in neuroendocrine disruption. Gen Comp Endocrinol. 2014 Jul 1;203:158-73. Cao M, Chen J, Peng W, Wang Y, Liao L, Li Y, Trudeau VL, Zhu Z, Hu W. Effects of growth hormone over-expression on reproduction in the common carp Cyprinus carpio L. Gen Comp Endocrinol. 2014 Jan 1;195:47-57. Lanctôt C, Robertson C, Navarro-Martín L, Edge C, Melvin SD, Houlahan J, Trudeau VL. Effects of the glyphosate-based herbicide Roundup WeatherMax® on metamorphosis of wood frogs (Lithobates sylvaticus) in natural wetlands. Aquat Toxicol. 2013 Sep 15;140-141:48-57. Silva de Assis HC, Simmons DB, Zamora JM, Lado WE, Al-Ansari AM, Sherry JP, Blais JM, Metcalfe CD, Trudeau VL. Estrogen-like effects in male goldfish co-exposed to fluoxetine and 17 alpha-ethinylestradiol. Environ Sci Technol. 2013 May 21;47(10):5372-82. Melvin SD, Lanctôt CM, Craig PM, Moon TW, Peru KM, Headley JV, Trudeau VL. Effects of naphthenic acid exposure on development and liver metabolic processes in anuran tadpoles. Environ Pollut. 2013 Jun;177:22-7. Trudeau VL, Schueler FW, Navarro-Martin L, Hamilton CK, Bulaeva E, Bennett A, Fletcher W, Taylor L. Efficient induction of spawning of northern leopard frogs (Lithobates pipiens) during and outside the natural breeding season. Reprod Biol Endocrinol. 2013 Feb 25;11:14. Popesku JT, Martyniuk CJ, Trudeau VL. Meta-type analysis of dopaminergic effects on gene expression in the neuroendocrine brain of female goldfish. Front Endocrinol (Lausanne). 2012 Nov 2;3:130. Trudeau VL, Martyniuk CJ, Zhao E, Hu H, Volkoff H, Decatur WA, Basak A. Is secretoneurin a new hormone? Gen Comp Endocrinol. 2012 Jan 1;175(1):10-8. Zhao E, McNeilly JR, McNeilly AS, Fischer-Colbrie R, Basak A, Seong JY, Trudeau VL. Secretoneurin stimulates the production and release of luteinizing hormone in mouse L{beta}T2 gonadotropin cells. Am J Physiol Endocrinol Metab. 2011 Aug;301(2):E288-97.