Pamenter, Matthew - University of Ottawa

个人简介

At the crossroads of comparative physiology and basic neuroscience, the Pamenter Lab is focused on the study and exploitation of naturally evolved mechanisms of hypoxia-tolerance in the brain. By examining both proactive and reactive responses to low oxygen stress in the brains of hypoxia-tolerant and –intolerant species (respectively), we seek to understand the synaptic, cellular, and systemic adaptations that allow some species to tolerate acute or prolonged low oxygen stress, whereas others suffer rapid cellular and whole organism death. Advancing our knowledge in this area will allow us to develop a deeper understanding of pure biological questions related to the control and evolution of systemic responses to hypoxia. In addition, it may also provide an applied translational benefit by informing the development of novel strategies and therapeutics to treat pathologies related to hypoxia, such as ischemic stroke and chronic pulmonary disorders.

近期论文

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Pamenter ME, Dzal Y and Milsom WK (2015). Adenosine receptors inhibit the hypoxic ventilatory response but not the hypoxic metabolic response in the naked mole rat during acute hypoxia. Proceedings of the Royal Society B. 282(1800):20141722. Pamenter ME, Go A, Fu Z, Carr JA, Reid SG and Powell FL (2014). Glutamate receptors in the nucleus tractus solitarii mediate ventilatory acclimatization to hypoxia in rat. Journal of Physiology (London). 592(8):1839-1856. Pamenter ME (2014). Mitochondria: A multimodal hub of hypoxia-tolerance. Canadian Journal of Zoology. Invited review, special issue: Animal Mitochondria. 92:569-589. Pamenter ME, Hogg DW, Gu XQ, Buck LT and Haddad GG (2012). Painted turtle cortex is resistant to an in vitro mimic of the ischemic mammalian penumbra. Journal of Cerebral Blood Flow and Metabolism. 32(11)2033-2043. Pamenter ME, Hogg DW, Ormond J, Shin DS, Woodin MA and Buck LT (2011). Endogenous GABA(A) and GABA(B) receptor-mediated electrical suppression is critical to neuronal anoxia tolerance. Proceedings of the National Academy of Sciences (USA). 108(27):11274-11279.