研究领域

Research focuses on how organisms adjust to their environment and to environmental change. The emphasis is on the evolution of hormone receptors and their signalling pathways especially with respect to the stress axis, the role of nutrient signals in partitioning cellular metabolism, and the metabolic consequences of environmentally relevant pollutants, including persistent organics, pharmaceuticals and nanoparticles. Fish serve as model organisms and studies cover all levels of functional organization from the gene to the whole fish within its environment.

The link between diversity and environmental perturbations is a complex suite of biochemical and physiological mechanisms that allow organisms to adjust within limits to changes in their environment. My laboratory uses fish (primarily although not exclusively) to unravel these complex adaptations as fish are in intimate contact with their aquatic environment and can serve as ideal sentinel species for changes to our aquatic resources, and fish represent the largest group of vertebrate species and thus ideal model organisms to track changes in the aquatic environment and to explore evolutionary changes within the vertebrates. We examine all levels of organization from the gene to the whole fish. We use a variety of fish species dependent upon the experimental questions posed. For example, the zebrafish Danio rerio is an excellent model fish species and is the premier developmental model used in research today. However its size precludes 'real' physiological estimates so the rainbow trout (Oncorhynchus mykiss) and goldfish (Carassius auratus) are more appropriate 'physiclogical' models. In addition trout are carnivores and ominivores, respectively and can be effective nutritional models. So as August Krogh clearly stated "For many problems there is an animal on which it can be most conveniently studied", some species are more appropriate models than others, depending upon the experiment. Presently my laboratory is working principally on fish species and two principle themes but multiple components of these themes.

近期论文

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Polakof, S., J.M Míguez, T.W. Moon, and J.L. Soengas. Evidence for the presence of a glucosensor in hypothalamus, hindbrain and Brockmann bodies of rainbow trout. Am. J. Physiol. Regul. Integr. Comp. Physiol. 292: R1657-1666., 2007 Chen, X., Perry, S.F., Aris-Brosou, S., Selva, C., Moon, T.W. Characterization and functional divergence of ?1-adrenoceptor gene family: insights from the rainbow trout (Oncorhynchus mykiss). Physiol. Genomics 32: 142-153, 2007 Aris-Brosou, S., Chen, X., Perry, S.F., Moon, T.W. Timing of the functional diversification of a- and ß-adrenoceptors in fish and other vertebrates. Trends in Comp. Endocrinol. Neurobiol.; Ann. N.Y. Acad. Sci. 1163: 343-347, 2009 Mennigen, J.A., Harris, E.A., Chang, J.P., Moon, T.W., Trudeau, V.L. Fluoxetine affects weight gain and expression of feeding peptides in the female goldfish brain. Regul. Pept. 155: 99-104, 2009 Marlatt, V., Lakoff, J., Crump, K., Martyniuk, C., Watt, J., Jewell, L., Atkinson, S., Blais, J., Sherry, J., Moon, T.W., Trudeau, V. Sex- and tissue-specific effects of waterbone estrogen on estrogen receptor subtypes and E2-mediated gene expression in the reproductive axis of goldfish. Comp. Biochem. Physiol. 156 A, 92-101, 2009