Kassen, Rees - University of Ottawa - Department of Biology

研究领域

Dr. Kassen’s research aims to answer the most fundamental and persistent puzzle of nature: the origin and maintenance of biodiversity. Or, put another way, we are trying to answer the age-old question, “Why are there so many species in the world?” To do this requires that we study the evolutionary process as it unfolds, keeping track of the variety of genotypes and phenotypes in a population or community through time, a task that would be very challenging with any large, long-lived organism. For this reason, we use microbial populations of bacteria and protists to study the evolutionary process in the laboratory. Topics of investigation include, but are not limited to, (1) the genetics of adaptation and niche specialization, (2) adaptive radiation, (3) social interactions, (4) invasive species, (5) evolutionary medicine.

近期论文

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Dettman J, Rodrigue N, Schoutra SE, Kassen R. 2017. Genomics of compensatory adaptation in experimental populations of Aspergillus nidulans. G3 in press Rode N, Soroye P, Kassen R, Rundle H. 2017. Air-borne genotype by genotype indirect genetic effects are substantial in the filamentous fungus Aspergillus nidulans. Heredity in press Shewaramani S, Finn TJ, Leahy SC, Kassen R, Rainey PB, Moon CD. 2017. Anaerobically grown Escherichia coli have an enhanced mutation rate and distinct mutational spectra. PLoS Genetics in press Bailey SF, Blanquart F, Bataillon T, Kassen R. 2017. What drives parallel evolution? BioEssays 39: 1600176 online open access Kraemer S & Kassen R. 2016. Temporal patterns of local adaptation in soil pseudomonads. Proc R Soc B 283: 20161652 online open access Dettman JD, Sztepanacz JL & Kassen R. 2016. The properties of spontaneous mutations in the opportunistic pathogen Pseudomonas aeruginosa. BMC Genomics 17: 27 pdf Schick, A, Bailey, SF & Kassen, R. 2015. Evolution of fitness trade-offs in locally adapted populations of Pseudomonas fluorescens. American Naturalist 186: S48-S59 Bailey, SF, Rodrigue, N & Kassen, R. 2015. The effect of selection environment on the probability of parallel evolution. Molecular Biology and Evolution doi:10.1093/molbev/msv033 pdf Kraemer, S. & Kassen, R. 2015. Patterns of local adaptation in space and time among soil bacteria. American Naturalist 185: 317-331. pdf Melnyk, AH, Wong, A & Kassen, R. 2015. The fitness costs of antibiotic resistance mutations. Evolutionary Applications doi: 10.1111/eva.12196. pdf Dettman, JR, Rodrigue, N & Kassen, R. 2015. Genome-Wide Patterns of Recombination in the Opportunistic Human Pathogen Pseudomonas aeruginosa. Genome Biology and Evolution 7: 18-34. pdf Bailey, SF, Hinz, A & Kassen, R. 2014. Adaptive synonymous mutations in an experimentally evolved Pseudomonas fluorescens population. Nature Communications 5: 4076. pdf Kassen, R. 2014. Experimental Evolution and the Nature of Biodiversity. Roberts and Company, Publishers. Website Bailey, SF, Dettman, JR, Rainey, PB & Kassen, R. 2013. Competition both drives and impedes diversification in a model adaptive radiation. Proceedings of the Royal Society B 280: 20131253. pdf Dettman, JR, Rodrigue, N, Aaron, SD & Kassen, R. 2013. Evolutionary genomics of epidemic and nonepidemic strains of Pseudomonas aeruginosa. Proceedings of the National Academy of Sciences USA 110: 21065-21070. pdf Schoustra, SE, Kasase, C, Toarta, C, Kassen, R. & Poulain, A. J. 2013. Microbial Community Structure of Three Traditional Zambian Fermented Products: Mabisi, Chibwantu and Munkoyo. PLoS ONE 8: e63948. pdf Bailey, SF & Kassen, R. 2012. Spatial structure of ecological opportunity drives adaptation in a bacterium. American Naturalist 180: 270-283. pdf Dettman, JR, Rodrigue, N, Melnyk, AH, Wong, A, Bailey, SF & Kassen, R. 2012. Evolutionary insight from whole-genome sequencing of experimentally evolved microbes. Molecular Ecology 21: 2058-2077. pdf Schoustra, SE, Dench, J, Dali, R, Aaron, SD & Kassen, R. 2012. Antagonistic interactions peak at intermediate genetic distance in clinical and laboratory strains of Pseudomonas aeruginosa. BMC Microbiology 12: 40. pdf Schoustra, SE, Punzalan, D, Dali, R, Rundle, HD. & Kassen, R. 2012. Multivariate Phenotypic Divergence Due to the Fixation of Beneficial Mutations in Experimentally Evolved Lineages of a Filamentous Fungus. PLoS ONE 7:e50305. pdf Wong, A, Rodrigue, N & Kassen, R. 2012. Genomics of Adaptation during Experimental Evolution of the Opportunistic Pathogen Pseudomonas aeruginosa. PLoS Genetics 8:e1002928. pdf