研究领域

The research performed in this lab involves the evolutionary genomics of ecologically relevant and medically important fungi. In particular, the research focuses on two fungal organisms that are evolutionary unrelated but equally intriguing: the Arbuscular Mycorrhizal Fungi (AMF) and the Microsporidia. AMF represent an ecologically relevant group of ancient asexuals that form widespread symbioses with the roots of most land plants. These organisms have unusual cellular features, as each mycelium is composed of thousands of nuclei that coexist within one cytoplasm and by an elevated intracellular molecular diversity . The research aims to understand the origin and evolution of this peculiar polymorphism, and to acquire long-awaited insights into the content and structure of AMF genomes by comparing large genome and transcriptome sequence data. In parallel, a large chunk of our research focuses on the acquisition and comparative analysis of genomic data from a group of obligate intracellular parasites called Microsporidia. Most species of this group are characterized by miniaturized genomes, which we use as models to study the evolution of eukaryotic parasite genomes in a broad sense

- Comparative and Population Genomics of Plant Symbionts - Parasite Genome Evolution - Experimental Evolution of Microbial Symbionts and Parasites - Phylogenomics of Early Branching Fungi

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Corradi N. and A. Brachmann. 2017. Fungal mating in the most widespread plant symbionts? Trends in Plant Sciences. Ropars J., Kinga Sędzielewska Toro K. Noel J., Pelin A., Charron P., Farinelli L., Marton T., Krüger M., Fuchs J., Brachmann A. and N.Corradi. Evidence for the sexual origin of heterokaryosis in Arbuscular Mycorrhizal Fungi. 2016. Nature Microbiology 1, 16033. N. Corradi. Microsporidians: Intracelllar parasites shaped by gene loss and horizontal gene transfers. 2015. Annual Review of Microbiology. 69 (1), 167-183. Pelin A., Selman M., Laurent Farinelli, Aris-Brosou S. and N. Corradi. Genome analyses suggest the presence of polyploidy and recent human-driven expansions in eight global populations of the honeybee pathogen Nosema ceranae. 2015. Environmental Microbiology, 17 (11), 4443-4458. Riley R., Charron P., Idnurm A., Farinelli L., Dalpé Y., Martin F. and N. Corradi. Extreme diversification of the MATA-HMG gene family in the plant - associated arbuscular mycorrhizal fungi. 2014. New Phytologist. 201: 254–268.