daCosta, Corrie - University of Ottawa - Department of Chemistry and Biomolecular Sciences

个人简介

Dr. daCosta examines structure-function relationships in a class of proteins called ligand-gated ion channels, which are ion-conducting pores embedded in cell membranes. Evolved to convert chemical signals into electrical impulses, ligand-gated ion channels mediate fundamental physiological processes, are implicated in numerous human diseases, and are the targets of a wide variety of drugs. Dr. daCosta seeks to both control ligand-gated ion channel function with chemistry, and to engineer ligand-gated ion channels with unique and useful properties.

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17) Nuriya Mukhtasimova, Corrie J.B. daCosta, and Steven M. Sine. Improved resolution of single channel dwell times reveals mechanisms of binding, priming, and gating in muscle AChR. (2016) Journal of General Physiology. 148(1):43-63. PubMed ID: 27353445 16) Corrie J.B. daCosta*, Chris R. Free, and Steven M. Sine*. Stoichiometry for α-bungarotoxin block of α7 acetylcholine receptors. (2015) Nature Communications. 6:8057 doi: 10.1038/ncomms9057. PubMed ID: 26282895 *co-corresponding authors 15) Camille M. Hénault, Jiayin Sun, J.P. Daniel Therien, Corrie J.B. daCosta, Casey L. Carswell, Jonathan M. Labriola, Peter F. Juranka, and John E. Baenziger. The role of the M4 lipid-sensor in the folding, trafficking, and allosteric modulation of nicotinic acetylcholine receptors. (2014) Neuropharmacology. 96(Pt B):157-68. PubMed ID: 25433148 14) Corrie J.B. daCosta*, Lopamudra Dey*, J.P. Daniel Therien, and John E. Baenziger A distinct mechanism for activating uncoupled nicotinic acetylcholine receptors. (2013) Nature Chemical Biology. 9(11):701-707. PubMed ID: 24013278 *co-first authors 13) Corrie J.B. daCosta and John E. Baenziger. Gating of pentameric ligand-gated ion channels: structural insights and ambiguities. (2013) Structure. 21(8):1271-1283. PubMed ID: 23931140 12) Steven M. Sine, Sun Huang, Shu-xing Li, Corrie J.B. daCosta, and Lin Chen. Inter-residue coupling contributes to high-affinity subtype-selective binding of α-bungarotoxin to nicotinic receptors. (2013) Biochemical Journal. 454(2):311-321. PubMed ID: 23802200 11) Corrie J.B. daCosta* and Steven M. Sine*. Stoichiometry for drug potentiation of a pentameric ion channel. (2013) Proceedings of the National Academy of Science. 110(16):6595-6600. PubMed ID: 23576748 *co-corresponding authors 10) Corrie J.B. daCosta, Chris R. Free, Jeremías Corradi, Cecilia Bouzat, and Steven M. Sine. Single-channel and structural foundations of neuronal α7 acetylcholine receptor potentiation. (2011) The Journal Neuroscience. 31(39):13870-13879. PubMed ID: 21957249 9) Corrie J.B. daCosta, R. Michel Sturgeon, Ayman K. Hamouda, Michael P. Blanton, and John E. Baenziger. Structural characterization and agonist binding to human α4β2 nicotinic receptors. (2011) Biochemical and Biophysical Research Communications. 407(3):456-460. PubMed ID: 21396349 8) Jonathan M. Labriola, Corrie J.B. daCosta, Shuzhi Wang, Daniel Figeys, Jeffrey C. Smith, R. Michel Sturgeon, and John E. Baenziger. Phospholipase C activity affinity purifies with the Torpedo nicotinic acetylcholine receptor. (2010) The Journal of Biological Chemistry. 285(14):10337-10343. PubMed ID: 20133947 7) Corrie J.B. daCosta, Sarah A. Medaglia, Nadine Lavigne, Shuzhi Wang, Casey L. Carswell and John E. Baenziger. Anionic lipids allosterically modulate multiple nicotinic acetylcholine receptor conformational equilibria. (2009) The Journal of Biological Chemistry. 284(49):33841-33849. PubMed ID: 19815550 6) Corrie J.B. daCosta* and John E. Baenziger*. A lipid-dependent uncoupled conformation of the acetylcholine receptor. (2009) The Journal of Biological Chemistry. 284(26):17819-17825. PubMed ID: 19357079 *co-corresponding authors 5) John E. Baenziger, Stephen E. Ryan, Michael M. Goodreid, Ngoc Q. Vuong, R. Michel Sturgeon, and Corrie J.B. daCosta. Lipid composition alters drug action at the nicotinic acetylcholine receptor. (2008) Molecular Pharmacology. 73(3):880-890. PubMed ID: 18055762 4) Corrie J.B. daCosta, Daniel E. E. Kaiser, and John E. Baenziger. Role of glycosylation and membrane environment in nicotinic acetylcholine receptor stability. (2005) Biophysical Journal. 88(3), 1755-1764. PubMed ID: 15626708 3) Corrie J.B. daCosta, Ian D. Wagg, Marlene E. McKay, and John E. Baenziger. Phosphatidic acid and phosphatidylserine have distinct structural and functional interactions with the nicotinic acetylcholine receptor. (2004) The Journal of Biological Chemistry. 279(15):14967-14974. PubMed ID: 14752108 2) Corrie J.B. daCosta and John E. Baenziger. A rapid method for assessing lipid:protein and detergent:protein ratios in membrane-protein crystallization. (2003) Acta Crystallographica. D59(Pt 1):77-83. PubMed ID: 12499543 1) Corrie J.B. daCosta, Andrei A. Ogrel, Elizabeth A. McCardy, Michael P. Blanton, and John E. Baenziger. Lipid-protein interactions at the nicotinic acetylcholine receptor: a functional coupling between nicotinic receptors and phosphatidic acid containing bilayers. (2002) The Journal of Biological Chemistry. 277(1):201-208. PubMed ID: 11682482