Picketts, David - University of Ottawa - Department of Biochemistry, Microbiology and Immunology

个人简介

Dr. Picketts completed a PhD at Queen's University (Kingston) with Dr. David Lillicrap studying the transcriptional regulation of the Factor IX gene. He then pursued postdoctoral research in Oxford, England with Dr. Douglas Higgs at the Institute of Molecular Medicine. With another research fellow, Dr. Richard Gibbons they identified the ATRX gene as the cause of the ATR-X syndrome, a severe form of X-linked intellectual disability (XLID). They cloning of the ATRX gene established the paradigm that dysfunctional chromatin remodeling proteins cause human disease, specifically neurodevelopmental disorders. Dr. Picketts has extended his research to explore the role of three other chromatin-interacting proteins in disease and brain development including PHF6 and the ISWI proteins, SNF2H and SNF2L. In his spare time, Dr. Picketts remains an avid ice hockey enthusiast playing and coaching several times a week and he is an alumni of the Oxford Ice Hockey Team.

研究领域

ATP-dependent chromatin remodeling, Brain development, Intellectual disability, Heterochromatin maintenance.

近期论文

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Gibbons, RJ, Picketts, DJ, and Higgs, DR. (1995) X-linked mental retardation associated with a thalassaemia (ATR-X syndrome) results from mutations in a putative global transcriptional regulator. Cell 80, 837-845. Barak, O., Lazzaro, MA., Lane, WS., Speicher DW., Picketts, DJ., Shiekhattar R. Isolation of human NURF: a regulator of Engrailed gene expression. EMBO J. (2003) 22:6089-6100. Bérubé, NG, Jagla M, Vanderluit, JL, Garrick, D, Gibbons, RJ, Higgs, DR, Slack, RS, and Picketts, DJ. The chromatin remodeling protein ATRX is critical for neuronal survival during corticogenesis. (2005) J. Clin. Invest. 115: 258-267. Impact Factor: 15.754 Yip, DJ, Corcoran, CP, DeMaria, A, Rennick, S, Rudnicki, MA, Messier, C, and Picketts DJ. Snf2l regulates Foxg1-dependent progenitor cell expansion in the developing brain. (2012) Dev Cell. 2012 Apr 17;22(4):871-8. Impact Factor: 14.030 Alvarez-Saavedra, M., Lagali, P., Yan, K., Mears, A., De Repentigny, Y., Hashem, E., Wallace, V.A., Kothary, R., Stopka, T., Skoultchi, A.I., and Picketts, D.J. Snf2h mediates histone dynamics to control cerebellar development and function. Nature Comm (2014) 5:4181 1. Picketts, DJ, Mayanil, C.S.K., and R.S. Gupta.(1989) Molecular cloning of a Chinese Hamster mitochondrial protein related to the "chaperonin" family of bacterial and plant proteins. J. Biol. Chem. 264, 12001-12008 2. Gupta, R.S., Picketts, DJ, and S.Ahmad. (1989) A novel ubiquitous protein "chaperonin" supports the endosymbiotic origin of mitochondrion and plant chloroplasts. Biochem. Biophys. Res. Comm. 163, 780-787 3. Picketts, DJ, D'Souza, C., Bridge,P.J., and D.P. Lillicrap. (1992) An A to T transversion at position -5 in the factor IX promoter results in hemophilia B. Genomics 12, 161-163 4. Picketts, DJ, Cameron, C., Taylor,S.A.M., Deugau, K.V., and D.P. Lillicrap.(1992) Differential termination of primer extension: A novel, quantifiable method for the detection of point mutations. Human Genetics 89, 155-157. 5. Picketts, DJ, Lillicrap, D.P., and C.R.Mueller (1993) Synergy between the transcription factors DBP and C/EBP compensate for a Hemophilia B Factor IX promoter mutation. Nature Genetics 3, 175-179. 6. Picketts, DJ; Mueller, C.R.; Lillicrap, D.P.(1994) Transcriptional control of the factor IX gene: Analysis of 5 cis-acting elements and the deleterious effects of naturally occuring hemophilia B Leyden mutations. Blood 84, 2992-3000. 7. Bernet, A., Sabatier, S., Picketts, DJ, Ouazana, R., Morle, F., Higgs, D.R., and Godet, J. (1995) Targeted inactivation of the major positive regulatoryelement (HS-40) of the human ?-globin gene locus. Blood 86, 1202-1211. 8. Vyas, P., Vickers, M.A., Picketts, DJ, and Higgs, D.R. (1995) Conservation of position and sequence of a novel, widely expressed gene containing the major human ?-globin regulatory element. Genomics 29, 679-689. 9. Gibbons, R.J., Picketts, DJ, and Higgs, D.R. (1995) Syndromal mental retardation due to mutations in a regulator of gene expression. Hum. Mol. Genet. 4 (Review) 1705-1709. 10. Gibbons, RJ, Picketts, DJ, and Higgs, DR. (1995) X-linked mental retardation associated with a thalassaemia (ATR-X syndrome) results from mutations in a putative global transcriptional regulator. Cell 80, 837-845. 11. Picketts, DJ, Higgs, DR, Bachoo, S, Blake, DJ, Quarrell, OWJ, and Gibbons,RJ. (1996) ATRX encodes a novel member of the SNF2 family of proteins: mutations point to a common mechanism underlying the ATR-X syndrome. Hum. Mol. Genet. 5, 1899-1907 12. Gibbons, RJ, Bachoo, S, Picketts, DJ, Aftimo, S, Asenbauer, B, Bergoffen, JA, Berry, SA, Dahl, N, Fryer, A, Keppler, K, Kurosawa, K, Levin, ML, Masuno, M, Neri, G, Pierpont, ME, Slaney, SF, and Higgs, DR. (1997) Mutations in transcriptional regulator ATRX establish the functional significance of a PHD-like domain. Nature Genetics 17, 146-148 13. Picketts, DJ, Tastan, O, Higgs, DR, and Gibbons,RJ. Comparative sequence analysis identifies highly conserved, functionally important regions of the ATRX gene. (1998) Mamm Genome 9, 400-403. 14. McDowell,TL, Gibbons, RJ, Sutherland, H, O'Rourke, DM, Bickmore, WA, Pombo, A, Turley, H, Gatter, K, Picketts, DJ, Buckle VJ, Chapman, L, Rhodes, D, and Higgs, DR. Localisation of a putative transcriptional regulator (ATRX) at pericentromeric heterochromatin and the short arms of acrocentric chromosomes. (1999) Proc. Natl. Acad. Sci. USA 96, 13983-13988 15. Berubé NG, Smeenk CA, and Picketts DJ. Cell cycle dependent phosphorylation of the ATRX protein correlates with changes in nuclear matrix and chromatin association. (2000) Hum. Mol. Genet. 9, 539-547 16. Lazzaro MA and DJ Picketts. Cloning and Characterization of the murine Imitation Switch (ISWI) genes: Differential expression patterns suggest distinct developmental roles for Snf2h and Snf2l. (2001) J.Neurochem. 77, 1145-1157. 17. Bérubé NG, Jagla M, Smeenk C, De Repentigny Y, Kothary R, and Picketts DJ. Neurodevelopmental defects resulting from ATRX overexpression in transgenic mice. (2002) Hum. Mol. Genet. 11, 253-261 18. Barak, O., Lazzaro, MA., Lane, WS., Speicher DW., Picketts, DJ., Shiekhattar R. Isolation of human NURF: a regulator of Engrailed gene expression. EMBO J. (2003) 22:6089-6100. 19. Yip, DJ and D.J. Picketts. Increasing D4Z4 repeat copy number compromises C2C12 myoblast differentiation. (2003) FEBS Lett. 537, 133-138