Menzies, Keir - University of Ottawa - Department of Biochemistry, Microbiology and Immunology

个人简介

Keir Menzies is an assistant professor at the Interdisciplinary School of Health Sciences, Faculty of Health Sciences, and cross-appointed to the department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, at the University of Ottawa. His research spans metabolism in various organs and organisms with a special interest on the metabolic aspects of stem cell health and tissue regeneration in neuromuscular diseases.

近期论文

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D. Ryu*, H. Zhang*, E. R. Ropelle*, V. Sorrentino, D. A. G. Mazala, L. Mouchiroud, P. L. Marshall, M. D. Campbell, A. S. Ali, G. M. Knowels, S. Bellemin, S. R. Iyer, X. Wang, K. Gariani, A. A. Sauve, C. Canto, K. E. Conley, L. Walter, R. M. Lovering, E. R. Chin, B. J. Jasmin, D. J. Marcinek, K. J. Menzies#, J. Auwerx#: NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation. Science translational medicine 10/2016; 8(361). DOI:10.1126/scitranslmed.aaf5504 Karim Gariani, Dongryeol Ryu*, Keir Menzies*, Hyon-Seung Yi, Sokrates Stein, Hongbo Zhang, Alessia Perino, Vera Lemos, Elena Katsyuba, Pooja Jha, Sandrine Vijgen, Laura Rubbia-Brandt, Yong Kyung Kim, Jung Tae Kim, Koon Soon Kim, Minho Shong, Kristina Schoonjans, Johan Auwerx: Inhibiting poly-ADP ribosylation increases fatty acid oxidation and protects against fatty liver disease. Journal of Hepatology 09/2016; DOI:10.1016/j.jhep.2016.08.024 Hongbo Zhang, Dongryeol Ryu, Yibo Wu, Karim Gariani, Xu Wang, Peiling Luan, Davide D’Amico, Eduardo R. Ropelle, Matthias P. Lutolf, Ruedi Aebersold, Kristina Schoonjans, Keir J. Menzies#, Johan Auwerx#. NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice. Science 05/2016; DOI: 10.1126/science.aaf2693 Keir J Menzies, Hongbo Zhang, Elena Katsyuba, Johan Auwerx: Protein acetylation in metabolism—metabolites and cofactors. Nature Reviews Endocrinology 10/2015; DOI:10.1038/nrendo.2015.181 Karim Gariani*, Keir J. Menzies*, Dongryeol Ryu, Casey J. Wegner, Xu Wang, Eduardo R. Ropelle, Norman Moullan, Hongbo Zhang, Alessia Perino, Vera Lemos, Bohkyung Kim, Young-Ki Park, Alessandra Piersigilli, Tho X. Pham, Yue Yang, Chai Siah Ku, Sung I. Koo, Anna Fomitchova, Carlos Cantó, Kristina Schoonjans, Anthony A. Sauve, Ji-Young Lee, Johan Auwerx: Eliciting the mitochondrial unfolded protein response via NAD+ repletion reverses fatty liver disease. Hepatology 09/2015; DOI:10.1002/hep.28245 Carles Canto*, Keir J Menzies*, Johan Auwerx: NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus. Cell metabolism 06/2015; DOI:10.1016/j.cmet.2015.05.023 Keir Menzies, Johan Auwerx: An acetylation rheostat for the control of muscle energy homeostasis. Journal of Molecular Endocrinology 09/2013; DOI:10.1530/JME-13-0140 Keir J Menzies, Kaustabh Singh, Ayesha Saleem, David A Hood: Sirtuin 1-mediated Effects of Exercise and Resveratrol on Mitochondrial Biogenesis. Journal of Biological Chemistry 01/2013; 288(10). DOI:10.1074/jbc.M112.431155 Keir J Menzies, David A Hood: The role of SirT1 in muscle mitochondrial turnover. Mitochondrion. Mitochondrion 03/2011; 12(1):5-13. DOI:10.1016/j.mito.2011.03.001