Li, Xuguang - University of Ottawa - Department of Biochemistry, Microbiology and Immunology

个人简介

M.D., Medical College of Suzhou University Ph.D., McGill University Post-Doctoral Fellow, Dana Farber Cancer Institute, Harvard Medical School

研究领域

Dr. Sean (Xuguang) Li received his medical degree in Suzhou, China, followed by a graduate study training period in medical research in Beijing. He obtained his PhD from McGill University under the supervision of Prof Mark Wainberg and was a Research Fellow at the Dana Farber Cancer Institute of Harvard Medical School with Dr. Wayne Marasco. Currently, Dr. Li is a Senior Scientist at Health Canada, while serving as an Adjunct Professor at BMI and a member of Faculty of the Graduate and Postdoctoral Studies, University of Ottawa. The following are highlights of his research activities: Gene Therapy and Biotherapeutics: Targeted gene therapy and immunotherapeutics by viral vectors and molecular ligands Molecular Studies of influenza and other respiratory viruses in relation to replication and immunopathogenesis Vaccine Research: Investigation of universal epitopes of respiratory viruses for the induction of broad and long lasting immune responses Antibody Engineering: Selective generation of universal antibodies with high affinity to viral epitopes which are normally weak in immunogenicity

近期论文

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Hashem A, C Gravel, Z Chen, Y Yi, M Tocchi, B Jaentschke, X Fan, C Li, M Rosu-Myles, A Pereboev, R He, J Wang, X Li. 2014. CD40L preferentially modulates immune response and enhances protection against influenza virus. J. Immunol. (In press). Fan X, A M Hashem, Z Chen, C Li, T Doyle, Y Zhang, Y Yi, A Farnsworth , K Xu, R He, X Li*, J. Wang* (*Corresponding authors). 2014Targeting the HA2 subunit of influenza A virus hemagglutinin via CD40L provides universal protection against diverse subtypes. Mucosal Immunol. (In press) Doyle TD, AM Hashem, C. Li, G Van Domselaar, L Larocque, J. Wang, D Smith. T Cyr, A Farnsworth, R. He, AC Hurt, EG Brown, X. Li. 2013. Universal Anti-Neuraminidase Antibody Inhibiting all Influenza A Subtypes. Antiviral Res. 100 (2):567–574. (*Highlighted article for October, 2013). She YM, K Cheng, A Farnsworth, X. Li, TD Cyr. 2013. Surface Modifications of Influenza Proteins Upon Virus Inactivation by Beta-Propiolactone. Proteomics 13 (23-24):3537-47. Doyle TM., B. Jaentschke, G. Van Domselaar, A Hashem, A. Farnsworth, N. Forbes, C. Li., J. Wang., R. He, EG Brown, X. Li. 2013. The universal epitope of influenza A viral neuraminidase fundamentally contributes to enzyme activity and viral replication. J. Biol. Chem. 288(25):18283-9. Hashem A, C Gravel, A. Farnsworth, W. Zou, M Lemieux, K Xu, C. Li, J. Wang, M.F. Goneau, M. Merziotis, R He, M. Gilbert, X. Li. 2013. A novel synthetic receptor-based immunoassay for influenza vaccine quantification. PloS One;8(2):e55428. doi: 10.1371/journal.pone.0055428. Elmgren L, X. Li, C. Wilson, R. Ball, J. Wang, K. Cichutek, M. Pfleiderer, A. Kato, M. Cavaleri, J. Southern, T. Jivapaisarnpong, P. Minor, E. Griffiths, Y. Sohn, David Wood, 2012. A Global Regulatory Science Agenda for Vaccines. Vaccine. 2013 Apr 18;31 Suppl 2:B163-75 Yu L, C. Rao, X. Shi, Y Li, K. Gao, X. Li, J. Wang. 2012. A novel bioassay for the activity determination of therapeutic human brain natriuretic peptide (BNP). PloS One. 7(11):e49934. doi: 10.1371/journal.pone.0049934. Doyle T, X Li, 2012. Alternative roles of neuraminidase in influenza A viral propagation. J. Virol. Antiviral Res. 2012, 1:1 doi: 10.4172/jva.1000e104 Bliu A, M Lemieux, C. Li, X. Li, J. Wang and A. Farnsworth. 2012 Modifying the thermostability of inactivated influenza vaccines. Vaccine. 30(37):5506-11. Creskey MC, C Li, J Wang, M Girard, A Farnsworth, X.Li, DG Smith, TD Cyr. 2012. Simultaneous quantification of the viral hemagglutinin and neuraminidase in influenza vaccine by LC-MSE. Vaccine 30(32):4762-70. Hong A, D Han, CJ Wright, T Burch, J Piper, C Osiowy, C Gao, K Dick, TF Booth, X. Li, R He 2012. The Interaction between Hepatitis B Virus X Protein and AIB1 Oncogene is Required for the Activation of NFkB Signal Transduction. Biochem Biophys Res Comm. 423(1):6-12 Hashem AM, B. Jaentschke, C. Gravel, M Tocchi, TM Doyle, M Rosu-Myles, R He, X. Li. 2012 Subcutaneous immunization with recombinant adenovirus expressing influenza A nucleoprotein protects mice against lethal viral challenge. Hum Vaccin Immunother. 8(4): 1-4. Russell M, C. Li,, L. Larocque, A. Farnsworth, J. Wang, R He, X. Li. 2011 Rapid and Accurate Determination of the Potency of Varicella Vaccine by Quantitative Polymerase Chain Reaction. Vaccine 2011 Nov 3;29(47):8490-5. Hashem AM, TM Doyle, G Van Domselaar, A Farnsworth, C Li, J Wang, R He, X. Li. 2011, Recent Developments in Bioinformatics Analyses of Influenza A Virus Surface Glycoproteins and their Biological Relevance. Current Bioinformatics 6(4): 415 -426. Flaman AS, C Gravel, A.M. Hashem, M Tocchi, X. Li. 2011 The effect of interferon-α on the expression of cytochrome P450 3A4 in human hepatoma cells. Toxicol Appl Pharmacol. 253:130–136. Johnston MJ, Frahm G, X. Li, Durocher Y, Hefford MA. 2011. O-linked glycosylation leads to decreased thermal stability of interferon alpha 2b as measured by two orthogonal techniques. Pharmaceutical Research. 28(7):1661-1667. Lorbetskie B, J. Wang, C. Gravel, C. Allen, M. Walsh, A. Rinfret, X. Li, and M Girard. 2011. Quantitative Analysis of Hemagglutinin in Influenza Vaccine Preparations by Reversed-Phase HPLC on Non-Porous Silica: Optimization, Qualification, Comparative Evaluation with Western Blot and Single Radial Immunodiffusion Assays and Applicability during the 2009 H1N1 Influenza Pandemic. Vaccine 29(18):3377-89. Larocque L, A. Bliu, R. Xu, A Diress, J Wang, R. Lin, R. He, M. Girard, X. Li . 2011. Bioactivity determination of native and variant forms of therapeutic interferons. J. Biomed. Biotechnol. 2011;2011:174615 Farnsworth A., T.D. Cyr, C. Li, J. Wang, and X. Li. 2011. Antigenic stability of H1N1 pandemic vaccines correlates with vaccine strain. Vaccine 29(8):1529-33 Gravel C, C Li, J Wang, B Jaentschke, G Van Domselaar, R He, X. Li. 2011. Quantitative Analyses of all Influenza Type A Viral Hemagglutinins and Neuraminidases using Universal Antibodies in simple Slot Blot Assays. J. Vis. Exp. 2011 Apr 4;(50). pii: 2784. doi: 10.3791/2784. Hashem A, G. Van Domselaar, C. Li, J. Wang, Y-M She, T.D. Cyr, J. Sui, R. He, W.A. Marasco, X. Li. 2010.Universal Antibodies against the Highly Conserved Influenza Fusion Peptide Cross-Neutralize Several Subtypes of Influenza A Virus. Biochem Biophys Res Comm. 403: 247–251 Gravel C, C. Li, J. Wang, AM. Hashem, B. Jaentschke, KW Xu, B. Lorbetskie, G. Gingras, Y. Aubin, GV Domselaar, M. Girard, R. He, X. Li 2010 Qualitative and quantitative analyses of virtually all subtypes of influenza A and B viral neuraminidases using antibodies targeting the universally conserved sequences Vaccine. 28(36):5774-84. Farnsworth A, A S. Flaman, S. S. Prassad, C. Gravel, A. Williams, C.L. Yauk, X. Li 2010 Modulation of the transcriptional response to recombinant IFN-ß following the administration of Acetaminophen. Plos One. 5(6): e11031. Li C, B. Jaentschke, Y. Song, J. Wang, T. Cyr, G. Van Domselaar, R. He, X. Li. 2010. A simple slot blot for the detection of virtually all subtypes of the influenza A viral hemagglutinins using universal antibodies targeting the fusion peptide. Nat. Protoc. 5(1):14-19.