Figeys, Daniel - University of Ottawa - Department of Biochemistry, Microbiology and Immunology

个人简介

Dr. Daniel Figeys joined the University of Ottawa in July of 2004 as a Professor in the Department of Biochemistry, Microbiology and Immunology and the Director of the new Institute of Systems Biology. Daniel obtained a B.Sc. and a M.Sc. in chemistry from the Université de Montréal. He obtained a Ph.D. in Chemistry from the University of Alberta and did his postdoctoral studies at the University of Washington. Prior to his current position, Dr. Daniel Figeys was Senior VP of System Biology and Lead Profiling with MDS-Proteomics (2000-2004). He was responsible for all the analytical functions of MDS-Proteomics. Before joining MDS-Proteomics, Dr. Figeys was Director of Mass Spectrometry and Applied Research MDS Ocata, a privately held company from January to December 2000. From 1998 to 2000, Dr. Figeys was a Research Officer at the NRC-Canada in the field of proteomics technology and application. He ran a very active research laboratory involved in industrial applications of proteomics. Daniel Figeys’s research involves developing proteomics technology and their applications in systems biology. This research is providing a comprehensive view of interplay between the biomolecules involved in proteomics and system biology. Dr. Figeys and his group are developing micro fluidic technologies to measure the level of proteins in minute amounts of biological samples as well as developing a high-throughput mapping technology to detect various kinds of protein modifications. Dr. Figeys is also working on the application of proteomics with other "omics" approaches to study human diseases in a systematic manner.

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Mitchell L, Huard S, Cotrut M, Pourhanifeh-Lemeri R, Steunou AL, Hamza A, Lambert JP, Zhou H, Ning Z, Basu A, Côté J, Figeys DA, Baetz K., mChIP-KAT-MS, a method to map protein interactions and acetylation sites for lysine acetyltransferases. Proc Natl Acad Sci USA. 2013 Apr 23;110(17):E1641-50. doi: 10.1073/pnas.1218515110. Epub 2013 Apr 9. Erratum in: Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4346. Fowler SL, Akins M, Zhou H, Figeys D, Bennett SA. The liver connexin32 interactome is a novel plasma membrane-mitochondrial signaling nexus. J Proteome Res. 2013 Jun 7;12(6):2597-610. doi: 10.1021/pr301166p. Epub 2013 Apr 26. Bennett SA, Valenzuela N, Xu H, Franko B, Fai S, Figeys D. Using neurolipidomics to identify phospholipid mediators of synaptic (dys)function in Alzheimer's Disease. Front Physiol. 2013 Jul 16;4:168. doi: 10.3389/fphys.2013.00168. eCollection 2013. Lanouette S, Mongeon V, Figeys D, Couture JF. The functional diversity of protein lysine methylation. Mol Syst Biol. 2014 Apr 8;10:724. doi: 10.1002/msb.134974. Xu H, Valenzuela N, Fai S, Figeys D, Bennett SA. Targeted lipidomics - advances in profiling lysophosphocholine and platelet-activating factor second messengers. FEBS J. 2013 Nov;280(22):5652-67. doi: 10.1111/febs.12423. Epub 2013 Jul 29. Review. Mayne J, Starr AE, Ning Z, Chen R, Chiang CK, Figeys D. Fine tuning of proteomic technologies to improve biological findings: advancements in 2011-2013. Anal Chem. 2014 Jan 7;86(1):176-95. doi: 10.1021/ac403551f. Epub 2013 Nov 22. Ning Z, Hawley B, Chiang CK, Seebun D, Figeys D. Detecting protein-protein interactions/complex components using mass spectrometry coupled techniques. Methods Mol Biol. 2014;1164:1-13. doi: 10.1007/978-1-4939-0805-9_1.