Crawley, Angela M. - University of Ottawa - Department of Biochemistry, Microbiology and Immunology

个人简介

Past Research training: Dr. Crawley received a B.Sc. in Microbiology and Immunology from McGill University in Montreal, Quebec (Canada) in 1999. In 2004 she completed a Ph.D. in Immunology with Dr. Bruce N. Wilkie in the Dept. of Pathobiology at the University of Guelph’s Ontario Veterinary College (Guelph, Ontario, Canada). Dr. Crawley then trained as a postdoctoral fellow in Dr. Jonathan B. Angel’s laboratory at the Ottawa Hospital Research Institute, and published 10 peer-reviewed scientific research and review articles on the immunopathogenesis of HIV infection. Dr. Crawley was funded by an Ontario HIV Treatment Network (OHTN) Fellowship award and awarded a University of Ottawa Faculty of Medicine Postdoctoral Award of Excellence (2007). Current appointment: Dr. Crawley was appointed as an Associate Scientist at the Ottawa Hospital Research Institute in April 2012. She is also an Adjunct Professor at the University of Ottawa and an Instructor at Carleton University, where she teaches immunology at the undergraduate, graduate and medical school levels. She teaches these courses in both English and French. Dr. Crawley has earned 2 salary awards: a CIHR New Investigator Award and an Ontario HIV Treatment Network (OHTN) Junior Investigator Development Award. Her research is funded by the OHTN, Canadian Foundation of AIDS Research and the J.P. Bickell Medical Research Foundation.

研究领域

HIV-HCV Immunology Lab

近期论文

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Crawley AM., Vranjkovic A., Faller E., McGuinty M., Burke SC., Cousineau S., MacPherson P., Angel JB. Jak/STAT and PI3K signalling pathways have both common and distinct roles in IL-7 mediated activities in human CD8+ T-cells. J. Leuk. Biol., 2014. 95(1):117-27. Crawley AM., and Angel JB. 2012. The influence of HIV on CD127 expression and its potential implications for IL-7 therapy. (Invited review article for Semin. Immunol., 24:231-240. Vranjkovic A., Crawley AM., Patey A., Angel JB. 2012. In vitro HIV Type 1 infection indirectly alters CD127 expression on CD8+ T-cells. AIDS Research and Human Retrovirology. 28:295-298. Crawley AM., and Angel JB. 2011. Expression of g-chain cytokine receptors on CD8+ T-cells in HIV infection with a focus on IL-7Ra (CD127). Immunol. Cell. Biol. 90:379-387. *Vranjkovic A., Crawley AM., Patey A., Angel JB. 2011. IL-7-dependent STAT-5 activation and CD8+ T-cell proliferation are impaired in HIV infection. J. Leuk. Biol., 89:499-506. Note: An editorial introduces this article in its issue: Paiardini M. et al., 2011. J. Leuk Biol. 89:491-3. O'Connor A., Crawley AM., Angel JB. 2010. The role of IL-7 in memory CD8+CD127+ T-cell function and its impairment in HIV disease. Immunol., 131(4):525-536. Crawley AM., Vranjkovic A., Young C., Angel JB. 2010. Interleukin-4 downregulates CD127 expression on human thymocytes and mature CD8+ T-cells. Eur. J. Immunol., 40:1396-1407. Crawley, AM., Faucher S., Angel JB. 2010. Soluble IL-7Ra (sCD127) inhibits IL-7 activity and is increased in HIV infection. J. Immunol., 184:4679-4787. Faucher S., Crawley AM., Decker W., Sherring A., Bogdanovic D., Ding T., Bergeron M., Angel JB., Sandstrom P. 2009. Development of a Quantitative Bead Capture Assay for Soluble IL-7 Receptor a in Human Plasma. PLoSONE, 4(8): e6690. Crawley AM., Katz T., Parato KP., Angel JB. 2009. IL-2 receptor g chain cytokines differentially regulate human CD8+CD127+ and CD8+CD127- T-cell division and susceptibility to apoptosis. Int. Immunol., 21: 29-42. Vranjkovic A.*, Crawley AM.* Gee K., Kumar A., Angel JB. 2007. IL-7 decreases IL-7 receptor-α (CD127) expression and induces shedding of CD127 by human CD8+ T cells. Int. Immunol., 19: 1329-1339. (*contributed equally).