Campbell, Malcolm - University of Guelph - Department of Molecular & Cellular Biology

个人简介

Prof. Malcolm Campbell joined the University of Guelph as vice-president (research) June 1, 2015. A distinguished scholar and accomplished plant genome biologist, Prof. Campbell has an outstanding academic leadership and research record. He published more than 60 peer-reviewed papers and has served on a number of editorial boards of distinguished journals. He also advises journal editorial boards, scientific and non-scientific advisory boards, and governmental, non-governmental and community organizations, and has served on the grant evaluation committee of the Natural Sciences and Engineering Research Council. Prof. Campbell was vice-principal of research at the University of Toronto Scarborough between 2009 and 2015, a period of extensive growth in the campus’s research activity and intensity, where he oversaw heightened research competitiveness and reputation. After 8 years as a tenured faculty member at Oxford University, he joined the University of Toronto in 2004. At University of Toronto, he held simultaneous professorial appointments in the Department of Cell and Systems Biology, the Faculty of Forestry, the Department of Biological Sciences, the Department of Ecology and Evolutionary Biology, and the Graduate Department of Environmental Sciences. He played a key role in founding University of Toronto’s Department of Cell and Systems Biology, and in developing the new department’s graduate program. Prof. Campbell undertook his Ph.D. in biochemistry at the University of Guelph and the University of British Columbia, and holds a BSc. in molecular biology from the University of Guelph. Following post-doctoral work in Toulouse, France and Raleigh, North Carolina, he held a tenured faculty position at the University of Oxford, along with a tutorial fellowship at Oxford’s Brasenose College, for eight years. The Vice-President’s office is located in the Executive Office suite on the fourth floor of the University Centre. Abeir El Arqusosi is the executive assistant to the Vice-President and can be reached at ext. 53081 (aarqusos@uoguelph.ca) To contact Dr. Campbell for VPR business, please use the email address here. For lab & personal business, please contact him here. For further information about University of Guelph research visit http://www.uoguelph.ca/research

研究领域

As they are literally rooted in place, plants possess remarkable mechanisms that perceive, interpret, and respond to internal and external cues so as to optimise plant growth & development relative to prevailing environment conditions. Despite the incredible diversity in plant forms, the molecular mechanisms that control plant responses to internal and external cues are highly conserved across diverse genera. The timing and localisation of these mechanisms shape plant & development. Our research team aims to gain greater insights into molecular mechanisms that plants employ to convert internal cues and external signals into appropriate adjustments in resource acquisition and allocation, focusing on the role of gene regulation in conditioning these adjustments. Toward this end, we test hypotheses related to the roles of small-molecule signaling, transcription factor function, epigenome modification, transcriptome remodeling, and transcriptional networks in conditioning plant responses to internal and external cues. We test hypotheses using comparative functional genomics / epigenomics approaches, bridging basic plant biology conducted with the model species A. thaliana to the economically and ecologically important genus Populus. Our research builds on experience in dissection of plant perception of sugars and water, reconfiguration of gene expression, and modification of plant function.

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Leaf size serves as a proxy for xylem vulnerability to cavitation in plantation trees. Schreiber SG, Hacke UG, Chamberland S, Lowe CW, Kamelchuk D, Bräutigam K, Campbell MM, Thomas BR. Plant Cell Environ. 2015 Jul 15. doi: 10.1111/pce.12611. [Epub ahead of print] Poplar trees reconfigure the transcriptome and metabolome in response to drought in a genotype- and time-of-day-dependent manner. Hamanishi ET, Barchet GL, Dauwe R, Mansfield SD, Campbell MM. BMC Genomics. 2015 Apr 21;16:329. doi: 10.1186/s12864-015-1535-z. Comprehensive multiphase NMR: a promising technology to study plants in their native state. Wheeler HL, Soong R, Courtier-Murias D, Botana A, Fortier-Mcgill B, Maas WE, Fey M, Hutchins H, Krishnamurthy S, Kumar R, Monette M, Stronks HJ, Campbell MM, Simpson A. Magn Reson Chem. 2015 Apr 9. doi: 10.1002/mrc.4230. [Epub ahead of print] Investigating the drought-stress response of hybrid poplar genotypes by metabolite profiling. Barchet GL, Dauwe R, Guy RD, Schroeder WR, Soolanayakanahally RY, Campbell MM, Mansfield SD. Tree Physiol. 2014 Nov;34(11):1203-19. doi: 10.1093/treephys/tpt080. Epub 2013 Oct 31. Investigating the drought-stress response of hybrid poplar genotypes by metabolite profiling. Barchet GL, Dauwe R, Guy RD, Schroeder WR, Soolanayakanahally RY, Campbell MM, Mansfield SD.Tree Physiol. 2013 Oct Interactions between the R2R3-MYB transcription factor, AtMYB61, and target DNA binding sites. Prouse MB, Campbell MM.PLoS ONE 2013;8(5):e65132 Interplay between sucrose and folate modulates auxin signaling in Arabidopsis. Stokes ME, Chattopadhyay A, Wilkins O, Nambara E, Campbell MM.Plant Physiol. 2013 Jul;162(3):1552-65 Epigenetic regulation of adaptive responses of forest tree species to the environment. Bräutigam K, Vining KJ, Lafon-Placette C, Fossdal CG, Mirouze M, Marcos JG, Fluch S, Fraga MF, Guevara MÁ, Abarca D, Johnsen O, Maury S, Strauss SH, Campbell MM, Rohde A, Díaz-Sala C, Cervera MT.Ecol Evol 2013 Feb;3(2):399-415 Constitutive expression of a fungal glucuronoyl esterase in Arabidopsis reveals altered cell wall composition and structure. Tsai AY, Canam T, Gorzsás A, Mellerowicz EJ, Campbell MM, Master ER.Plant Biotechnol. J. 2012 Dec;10(9):1077-87 Drought induces alterations in the stomatal development program in Populus. Hamanishi ET, Thomas BR, Campbell MM.J. Exp. Bot. 2012 Aug;63(13):4959-71 AtMYB61, an R2R3-MYB transcription factor, functions as a pleiotropic regulator via a small gene network. Romano JM, Dubos C, Prouse MB, Wilkins O, Hong H, Poole M, Kang KY, Li E, Douglas CJ, Western TL, Mansfield SD, Campbell MM.New Phytol. 2012 Sep;195(4):774-86 The interaction between MYB proteins and their target DNA binding sites. Prouse MB, Campbell MM.Biochim. Biophys. Acta 2012 Jan;1819(1):67-77 Clone history shapes Populus drought responses. Raj S, Bräutigam K, Hamanishi ET, Wilkins O, Thomas BR, Schroeder W, Mansfield SD, Plant AL, Campbell MM.Proc. Natl. Acad. Sci. U.S.A. 2011 Jul;108(30):12521-6 PlaNet: combined sequence and expression comparisons across plant networks derived from seven species. Mutwil M, Klie S, Tohge T, Giorgi FM, Wilkins O, Campbell MM, Fernie AR, Usadel B, Nikoloski Z, Persson S.Plant Cell 2011 Mar;23(3):895-910 Transcriptomic responses of the softwood-degrading white-rot fungus Phanerochaete carnosa during growth on coniferous and deciduous wood. MacDonald J, Doering M, Canam T, Gong Y, Guttman DS, Campbell MM, Master ER.Appl. Environ. Microbiol. 2011 May;77(10):3211-8 Endogenous overexpression of Populus MYB186 increases trichome density, improves insect pest resistance, and impacts plant growth. Plett JM, Wilkins O, Campbell MM, Ralph SG, Regan S.Plant J. 2010 Nov;64(3):419-32 Genome-wide analysis of plant metal transporters, with an emphasis on poplar. Migeon A, Blaudez D, Wilkins O, Montanini B, Campbell MM, Richaud P, Thomine S, Chalot M.Cell. Mol. Life Sci. 2010 Nov;67(22):3763-84 Time of day shapes Arabidopsis drought transcriptomes. Wilkins O, Bräutigam K, Campbell MM.Plant J. 2010 Sep;63(5):715-27 pubmed Intraspecific variation in the Populus balsamifera drought transcriptome. Hamanishi ET, Raj S, Wilkins O, Thomas BR, Mansfield SD, Plant AL, Campbell MM.Plant Cell Environ. 2010 Oct;33(10):1742-55